NCT05618158

Brief Summary

Young adults aged 18-26 engage in a number of behaviors that increase their risk of developing cancer later in life including sedentary lifestyles, unhealthy eating, nicotine produce us, heavy drinking of alcohol, increased UV exposure, and incomplete uptake of HPV vaccination. A multi-risk factor campaign will be developed to reduce these cancer risk behaviors and delivered to young adults over social media, a popular channel that can reach nearly all young adults. The campaign will be evaluated for effectiveness in a rigorous randomized trial with measures of moderate to vigorous physical activity, healthy eating patterns, nicotine product use, alcohol intake, sunburn prevalence, and HPV vaccination uptake.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,796

participants targeted

Target at P75+ for not_applicable cancer

Timeline
Completed

Started Apr 2024

Geographic Reach
1 country

5 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 8, 2022

Completed
8 days until next milestone

First Posted

Study publicly available on registry

November 16, 2022

Completed
1.4 years until next milestone

Study Start

First participant enrolled

April 20, 2024

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2025

Completed
Last Updated

December 26, 2025

Status Verified

December 1, 2025

Enrollment Period

1.4 years

First QC Date

November 8, 2022

Last Update Submit

December 24, 2025

Conditions

Cancer

Keywords

social mediacancer preventionnicotine usephysical activitynutritionsun protectionalcohol useHPV vaccinemedia literacy

Outcome Measures

Primary Outcomes (24)

  • Physical Activity

    Participants will self-report minutes per week of moderate to vigorous physical activity.

    Baseline

  • Physical Activity

    Participants will self-report minutes per week of moderate to vigorous physical activity.

    3 months

  • Physical Activity

    Participants will self-report minutes per week of moderate to vigorous physical activity.

    12 months

  • Physical Activity

    Participants will self-report minutes per week of moderate to vigorous physical activity.

    24 months

  • Diet

    Participants will self-report intake per day of fruits, vegetables, whole grains/fiber, added sugars (from sugar-sweetened beverages), and red/processed meats.

    Baseline

  • Diet

    Participants will self-report intake per day of fruits, vegetables, whole grains/fiber, added sugars (from sugar-sweetened beverages), and red/processed meats.

    3 months

  • Diet

    Participants will self-report intake per day of fruits, vegetables, whole grains/fiber, added sugars (from sugar-sweetened beverages), and red/processed meats.

    12 months

  • Diet

    Participants will self-report intake per day of fruits, vegetables, whole grains/fiber, added sugars (from sugar-sweetened beverages), and red/processed meats.

    24 months

  • Nicotine Product Use

    Participants will self-report tobacco/nicotine use in the past 30 days (every day, some days, not at all).

    Baseline

  • Nicotine Product Use

    Participants will self-report tobacco/nicotine use in the past 30 days (every day, some days, not at all).

    3 months

  • Nicotine Product Use

    Participants will self-report tobacco/nicotine use in the past 30 days (every day, some days, not at all).

    12 months

  • Nicotine Product Use

    Participants will self-report tobacco/nicotine use in the past 30 days (every day, some days, not at all).

    24 months

  • Alcohol Intake

    Participants self-report consumption of number of alcoholic drinks in the past 30 days.

    Baseline

  • Alcohol Intake

    Participants self-report consumption of number of alcoholic drinks in the past 30 days.

    3 months

  • Alcohol Intake

    Participants self-report consumption of number of alcoholic drinks in the past 30 days.

    12 months

  • Alcohol Intake

    Participants self-report consumption of number of alcoholic drinks in the past 30 days.

    24 months

  • Uv Exposure

    Participants will self-report number of sunburns.

    Baseline

  • Uv Exposure

    Participants will self-report number of sunburns.

    3 months

  • Uv Exposure

    Participants will self-report number of sunburns.

    12 months

  • Uv Exposure

    Participants will self-report number of sunburns.

    24 months

  • HPV Vaccination

    Participants will self-report whether or not they have received one or more doses of the HPV vaccine.

    Baseline

  • HPV Vaccination

    Participants will self-report whether or not they have received one or more doses of the HPV vaccine.

    3 months

  • HPV Vaccination

    Participants will self-report whether or not they have received one or more doses of the HPV vaccine.

    12 months

  • HPV Vaccination

    Participants will self-report whether or not they have received one or more doses of the HPV vaccine.

    24 months

Secondary Outcomes (28)

  • Physical Activity

    Baseline

  • Physical Activity

    3 months

  • Physical Activity

    12 months

  • Physical Activity

    24 months

  • Diet

    Baseline

  • +23 more secondary outcomes

Study Arms (1)

4 Corners Rural Cancer Prevention

EXPERIMENTAL

Four separate Facebook groups, which provide information via posts within the private groups about cancer risk factors (e.g. reducing alcohol consumption, tobacco use cessation, increasing physical activity), behavioral skills to reduce them, benefits of, social support for, and ways to reduce social/financial costs of cancer prevention, and advice from health care providers to decrease barriers. Posts will seek to improve self- and response-efficacy and perceived risk, and link cancer prevention to personal goals.

Behavioral: 4 Corners Rural Health Cancer Prevention

Interventions

4 Corners Rural Health Cancer PreventionBEHAVIORAL

Participants, aged 18-26, will join a private Facebook group to participate in the intervention. The group is not viewable to the public, including other Facebook users. Content that focuses on cancer prevention behaviors will be posted twice per day for up to 12 months. Each group will be hosted by a moderator who is responsible for managing the intervention goals and participants' engagement.

4 Corners Rural Cancer Prevention

Eligibility Criteria

Age18 Years - 26 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Aged 18-26 years old
  • Resides in a county coded as RUCC 4-9 in Arizona, Colorado, New Mexico, or Utah
  • Able to speak and read English
  • Has regular social media engagement
  • Accepts screening call from study staff
  • Consents to participate

You may not qualify if:

  • Participated in community engagement activities
  • Cannot speak and read English
  • Has low or no social media engagement
  • Does not accept a screening call from study staff
  • Does not consent to participate
  • Does not give permission for engagement data to be extracted from Facebook private group
  • If biologically female, currently pregnant

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (5)

University of Arizona

Tucson, Arizona, 85719, United States

Location

University of Colorado Denver

Aurora, Colorado, 80045-2570, United States

Location

Colorado State University

Fort Collins, Colorado, 80521-4593, United States

Location

University of New Mexico

Albuquerque, New Mexico, 87131-0001, United States

Location

University of Utah

Salt Lake City, Utah, 84112-5550, United States

Location

Related Publications (2)

  • Warner EL, Kinsey A, Walkosz BJ, Berteletti J, Nuss K, Small A, Woodall WG, Kepka D, Taren D, Skiba MB, Guest DD, Blair CK, Gordon JS, Wetter DW, Borrayo EA, Henry KL, Sussman AL, Buller DB. A Web-Based Cancer Prevention Intervention for Rural Emerging Adults: Mixed Methods Development and Pilot-Testing Study. J Med Internet Res. 2026 Jan 8;28:e80803. doi: 10.2196/80803.

    PMID: 41505184DERIVED

  • Buller DB, Sussman AL, Thomson CA, Kepka D, Taren D, Henry KL, Warner EL, Walkosz BJ, Woodall WG, Nuss K, Blair CK, Guest DD, Borrayo EA, Gordon JS, Hatcher J, Wetter DW, Kinsey A, Jones CF, Yung AK, Christini K, Berteletti J, Torres JA, Barraza Perez EY, Small A. #4Corners4Health Social Media Cancer Prevention Campaign for Emerging Adults: Protocol for a Randomized Stepped-Wedge Trial. JMIR Res Protoc. 2024 Feb 22;13:e50392. doi: 10.2196/50392.

    PMID: 38386396DERIVED

MeSH Terms

Conditions

NeoplasmsMotor ActivityAlcohol Drinking

Condition Hierarchy (Ancestors)

BehaviorDrinking Behavior

Study Officials

  • David Buller, PhD

    Klein Buendel, Inc.

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
PREVENTION
Intervention Model
SINGLE GROUP
Model Details: Randomized stepped-wedge with four cohorts
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 8, 2022

First Posted

November 16, 2022

Study Start

April 20, 2024

Primary Completion

August 31, 2025

Study Completion

August 31, 2025

Last Updated

December 26, 2025

Record last verified: 2025-12

Locations

US(5)