Evaluation of Pediatric Measles Cases in 2019: Single-Center Experience

NCT05614791 | Completed

• 1 other identifier: 2019.10.2.02.075
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 2

Brief Summary

Measles, can be prevented and eliminated by vaccination, is a highly contagious viral disease that can lead to serious complications, disability, and death. As a result of the World Health Organization (WHO) and United Nations International Children's Emergency Fund (UNICEF) strategic plans, the annual global incidence of measles decreased by 75% over the period 2000-2015, and the estimated global mortality rate fell by 73%. For the current 2019 period, the European and the Eastern Mediterranean Region has recorded respectively more than two-fold and 1.5-fold increase in reported measles cases. As it is known, no specific antiviral treatment exists for the measles virus therefore, vaccination is still the most effective method of preventing disease. The aim of this study was to evaluate the measles cases in districts where the refugees live quite intensely.

Conditions

Measles

Keywords

Measles; Vaccine; Children; Vitamin A

Outcome Measures

Primary Outcomes (2)

• Evaluate the effect of measles vaccination status on symptom duration

  compare the groups symptom durations (day) who fully, partly or not vaccinated

  baseline

• Evaluate the effect of vitamin A treatment on symptom duration

  compare the groups symptom durations (day) who get or not get vitamin A treatment

  in the first month after the first symptom observed

Secondary Outcomes (2)

• Evaluate the effect of measles vaccination status on leucocyte count

  baseline

• Evaluate the effect of vitamin A treatment on leucocyte count

  baseline

Other Outcomes (2)

• Evaluate the effect of measles vaccination status on cost of measles cases

  in the first month after the first symptom observed

• Evaluate the effect of vitamin A treatment on cost of measles cases

  in the first month after the first symptom observed

Eligibility Criteria

• Age: 1 Month - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Measles case according to with clinical features and attended Pediatric Clinic between 01 January-30 June 2019

You may qualify if:

• The suspicious case of measles
• Measles/Rubella Case Notification and Laboratory request and result form and Measles/ Rubella Case Study form must be filled
• Accept the informed consent form
• Positive Measles Ig M and Measles Ig G laboratory test

You may not qualify if:

• Rejected the informed consent form

Sponsors & Collaborators

• Marmara University: lead

Study Sites (2)

Esenler Maternity and Child Health Hospital

Istanbul, Esenler, 34230, Turkey (Türkiye)

Location

Haseki Training and Research Hospital

Istanbul, Turkey (Türkiye)

Location

Related Publications (3)

• Lord H, Kok J, Fletcher S, Alexander K. Is it or is it not? Lessons learned from a case of suspected vaccine strain measles. Aust N Z J Public Health. 2020 Apr;44(2):160-162. doi: 10.1111/1753-6405.12969. Epub 2020 Mar 19.

  PMID: 32190947 BACKGROUND

• Lo Vecchio A, Krzysztofiak A, Montagnani C, Valentini P, Rossi N, Garazzino S, Raffaldi I, Di Gangi M, Esposito S, Vecchi B, Melzi ML, Lanari M, Zavarise G, Bosis S, Valenzise M, Cazzato S, Sacco M, Govoni MR, Mozzo E, Cambriglia MD, Bruzzese E, Di Camillo C, Pata D, Graziosi A, Sala D, Magurano F, Villani A, Guarino A, Galli L; SITIP Measles Study Group. Complications and risk factors for severe outcome in children with measles. Arch Dis Child. 2020 Sep;105(9):896-899. doi: 10.1136/archdischild-2018-315290. Epub 2019 Jan 12.

  PMID: 30636224 BACKGROUND

• Filia A, Bella A, Del Manso M, Baggieri M, Magurano F, Rota MC. Ongoing outbreak with well over 4,000 measles cases in Italy from January to end August 2017 - what is making elimination so difficult? Euro Surveill. 2017 Sep 14;22(37):30614. doi: 10.2807/1560-7917.ES.2017.22.37.30614.

  PMID: 28933342 BACKGROUND

MeSH Terms

Conditions

Measles

Condition Hierarchy (Ancestors)

Morbillivirus Infections; Paramyxoviridae Infections; Mononegavirales Infections; RNA Virus Infections; Virus Diseases; Infections

Study Officials

• Mahmut Caner US, MD

  haseki Education and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D

Study Record Dates

• First Submitted: November 6, 2022
• First Posted: November 14, 2022
• Study Start: January 1, 2019
• Primary Completion: June 30, 2019
• Study Completion: May 30, 2020
• Last Updated: November 21, 2024

Record last verified: 2022-11

Locations

TU (2)