Exercise for Young Adults With Cancer
YOUEX
Implementation and Evaluation of Physical Exercise Services for Young Adults With Cancer
1 other identifier
interventional
106
1 country
1
Brief Summary
Over the past decade, importance of supportive care in cancer treatment of young cancer patients has increased. However, most common cancer-related side effects, such as physical deconditioning, psychological problems, infertility, and cancer-related fatigue, are particularly problematic for young adults (AYA). Short- and long-term side effects result in impaired quality of life, social life, and physical activity levels. While there is growing evidence that physical exercise is effective in reducing disease- or treatment-related side effects, programs are generally not tailored to the unique needs of young adults. In addition, social media or web-based programs are rarely structurally integrated into existing care programs. The objective of the Your Exercise Program (YOUEX) study is therefore to address these specific needs and to improve physical exercise services for young people in Germany. To this end, this pilot study presents three approaches to physical activity enhancement, with a particular focus on web-based and cross-regional programs. All three approaches will be evaluated for their feasibility and effectiveness on fatigue, distress, quality of life, and activity levels, as well as sustained effects over 24 weeks. The YOUEX study is an exploratory intervention study in the form of a 12-week exercise program for patients aged 18 to 39 years who currently have or have had a cancer diagnosis within the past 5 years. Eligible patients can choose from three support programs: Social Media Exercise Program, Online Exercise Platform, Supervised Exercise Program. The goal is to recruit 70 to 80 patients over an 8-month period. Evaluation questionnaires will be sent at three time points (T0: start of exercise program, T1: after 6 weeks; T2: after 12 weeks; T3: after 24 weeks) with a short weekly questionnaire between T0 and T2 to assess weekly adherence and changes in fatigue. YOUEX study will collect detailed information on the acceptability and feasibility of different physical activity programs for young people and their lasting effects on fatigue, quality of life and physical activity. Should these be positive, the findings can directly inform health care practice, which would be highly relevant especially in light of the COVID pandemic.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Sep 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
March 31, 2022
CompletedFirst Submitted
Initial submission to the registry
October 17, 2022
CompletedFirst Posted
Study publicly available on registry
November 14, 2022
CompletedNovember 14, 2022
November 1, 2022
1.1 years
October 17, 2022
November 4, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Feasibility of the three exercise interventions
Participants ability to follow the exercise prescription (measured by % of training frequency as well as type of the exercise)
During 12 week of the intervention
Secondary Outcomes (9)
Physical activity level
12 weeks and 24 weeks
Module Selection and preferences
Baseline, 6 weeks, 12 weeks
Impact of COVID-19 pandemic
Baseline, 6 weeks, 12 weeks, 24 weeks
Fatigue
Baseline, 6 weeks, 12 weeks, 24 weeks
Health-related quality of life
Baseline, 6 weeks, 12 weeks, 24 weeks
- +4 more secondary outcomes
Study Arms (3)
supervised, group-based, online-social media exercise program
OTHERunsupervised individual home-based training with an online-training app
OTHERsupervised, in-person exercise program close to place of residence
OTHERInterventions
The supervised online-social media exercise intervention took place once per week at a fixed, pre-scheduled time, via an online video conference platform. The training sessions lasted for 60 minutes and included a holistic workout with different focuses (e.g. resistance training for lower extremities, sensorimotor training, home-based endurance training). Patients were further recommended independent physical activity like walking or cycling, 1-2 times per week or to maintain the current volume of physical activity.
Exercise program in the online-app were personalized and focused on a combination of endurance and resistance training, 2-3 times a week, depending on patient's needs. Additional types of exercise (e.g. sensorimotor training) were added if therapy-related side effects were present. If necessary, exercise trainers conducted one introductory training session as video conference to check for exercise techniques and answer any individual questions.
The supervised exercise program close to patient's home was executed in a certified exercise facility of the network OnkoAktiv and supervised by special qualified exercise trainers. The weekly recommendation was to participate in a personalized in-person exercise program 1-2 per week, plus independent physical activity (or to maintain current level of physical activity)
Eligibility Criteria
You may qualify if:
- cancer diagnosis within the past five years
- signed informed consent
You may not qualify if:
- cancer-related cognitive impairment
- lack of sports clearance from the attending oncologist (e.g. in case of fragile bone metastases)
- current participation in another exercise intervention
- insufficient German language skills
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University Hospital Heidelberglead
- Charite University, Berlin, Germanycollaborator
- University Clinic Colognecollaborator
- University Clinic Essencollaborator
Study Sites (1)
National Center for Tumor Diseases
Heidelberg, Baden-Wurttemberg, 69120, Germany
Related Publications (1)
Voland A, Krell V, Gotte M, Niels T, Koppel M, Wiskemann J. Exercise Preferences in Young Adults with Cancer-The YOUEX Study. Curr Oncol. 2023 Jan 21;30(2):1473-1487. doi: 10.3390/curroncol30020113.
PMID: 36826074DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Joachim Wiskemann, PhD
Heidelberg University Hospital / National Center for Tumor Diseases
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Head Exercise Oncology
Study Record Dates
First Submitted
October 17, 2022
First Posted
November 14, 2022
Study Start
September 1, 2020
Primary Completion
September 30, 2021
Study Completion
March 31, 2022
Last Updated
November 14, 2022
Record last verified: 2022-11