Influence of TMS on Attention Modulation

NCT05611502 | Recruiting FDA Device

• 2 other identifiers: 21510R00AA027830
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to help understand how attention processes influence brain engagement during emotion and social cognition. The investigators also want to know if these processes are associated with drinking alcohol. Participation includes three study visits of about 2 hours each over approximately a month. The first visit involves a magnetic resonance imaging (MRI) scan and answering survey questions. Each of the next two visits will involve a session of transcranial magnetic stimulation (TMS, a non-invasive brain stimulation technique) followed by another MRI scan. People in the Auburn/Opelika area 19 or older are eligible to participate. People who drink alcohol and people who do not drink or don't drink very much are invited to participate.

Conditions

Drinking, Alcohol

Keywords

alcohol; attention; TMS; binge drinking; emotion; social cognition; moral; MRI; frontal eye fields; moral cognition

Outcome Measures

Primary Outcomes (3)

• Change in attention switching

  MRI Task- analysis of behavioral data

  Baseline, immediately following TMS A, immediately following TMS B

• Change in sociomoral attention switching

  MRI Task- analysis of behavioral data

  Baseline, immediately following TMS A, immediately following TMS B

• Change in cue reactivity

  MRI Task- analysis of behavioral data

  Baseline, immediately following TMS A, immediately following TMS B

Secondary Outcomes (3)

• Change in brain activity attention switching

  Baseline, immediately following TMS A, immediately following TMS B

• Change in brain activity during sociomoral attention switching

  Baseline, immediately following TMS A, immediately following TMS B

• Change in brain activity during cue reactivity

  Baseline, immediately following TMS A, immediately following TMS B

Study Arms (2)

TMS A

EXPERIMENTAL

TMS administered over right frontal eye field at 10 Hz, 110% of MT, 60 x 5 sec trains, 25 sec ITI

Device: TMS

TMS B

ACTIVE COMPARATOR

TMS administered over right frontal eye field at 1 Hz, 110% of MT, 7 x 225 sec trains, 30 sec ITI

Device: TMS

Interventions

TMS DEVICE

TMS will be administered in a pattern that is either excitatory or inhibitory.

Also known as: Magventure MagPro

TMS A; TMS B

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \. Age 18 or Older
• A. (Drinker Group): Reports consuming 4 \[if female\]/ 5 \[if male\] or more standard drinks on one occasion at least 2 times a month AND/OR reports consuming more than 7 \[if female\]/ 14 \[if male\] standard drinks per week on average
• B. (Healthy Volunteer Group): Reports consuming 4 \[if female\]/ 5 \[if male\] or more standard drinks on one occasion less than once a month AND reports consuming less than 7 \[if female\]/ 14 \[if male\] standard drinks per week on average

You may not qualify if:

• MRI Contraindications
• Presence of metal in the body that would make having a 7T MRI unsafe (including facial tattoos)
• Claustrophobia, such that individual would be unable to stay in the MRI for up to 1 hr
• Hearing loss, including tinnitus, that might be made worse by MRI or TMS
• TMS Contraindications
• Has ever had a seizure, or has a family history of epilepsy
• Taking medications or substances that lower the seizure threshold\*
• Implanted devices that are in the head or rely on physiological signals
• History of neurological disease, such as stroke or brain tumor
• Head injury with loss of consciousness greater than 30 minutes
• Actively withdrawing from alcohol
• Family history of schizophrenia or presence of psychotic symptoms

Sponsors & Collaborators

• Auburn University: lead
• National Institute on Alcohol Abuse and Alcoholism (NIAAA): collaborator

Study Sites (1)

Auburn University

Auburn, Alabama, 36849, United States

RECRUITING

MeSH Terms

Conditions

Alcohol Drinking; Binge Drinking

Condition Hierarchy (Ancestors)

Drinking Behavior; Behavior; Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Officials

• Samantha J Fede, PhD

  Principal Investigator

  PRINCIPAL INVESTIGATOR

Central Study Contacts

SCAMPI Lab

CONTACT

334-521-2807; scampi@auburn.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Participants will be randomly assigned to receive each arm in counterbalanced order (AB or BA).

Study Record Dates

• First Submitted: October 26, 2022
• First Posted: November 10, 2022
• Study Start: August 11, 2022
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: October 7, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF

Locations

US (1)