Drug Wastage : Observational Study in the Operating Rooms of France
GAME-OvBLOC
1 other identifier
observational
3,763
4 countries
83
Brief Summary
Environmental awareness is leading medical field to question its responsibility and possibilities for action. Drug residues can have a major environmental impact as per their bioaccumulation, toxicity and persistence characteristics, depending on where they are discarded. In France, drug residues should be disposed of by incineration, but in practice this is not systematic. Moreover, data on drug wastage in the operating rooms by anesthesia department are rare. The GAME-OvBLOC observational study aim to evaluate drug wastage in the operating rooms by anesthesia department in France and to propose ways of improving health care practices.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2023
Shorter than P25 for all trials
83 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 2, 2022
CompletedFirst Posted
Study publicly available on registry
November 8, 2022
CompletedStudy Start
First participant enrolled
April 6, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 20, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
July 20, 2023
CompletedApril 13, 2026
April 1, 2026
4 months
November 2, 2022
April 10, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Ratio of overall wastage in milliliter (mL) of prepared and discarded injectable drugs, to overall volume in milliliter (mL) of prepared injectable drugs
Wastage is defined as : any prepared and unused drug that remains in syringe
24 hours
Secondary Outcomes (7)
Reason for discarding drug residues
24 hours
Describe drug wastage for each kind of surgery/anesthesia
24 hours
Drug residues discarding process
24 hours
Cost of overall injectable drugs wastage
24 hours
Describe drug wastage for each age group
24 hours
- +2 more secondary outcomes
Study Arms (1)
Injectable drugs
Patient's data and data relating to prepared/administrated/discarded injectable drugs will be collected during 24 hours in the operating rooms by anesthesia department
Interventions
Drugs are prescribed at discretion of physicians. For each patient who have anesthesia in the operating room, all labelled syringes having contained drugs (name + dilution) are collected and analyzed.
Eligibility Criteria
All patients who will need an anesthesia act in operating room during a 24 hours period
You may qualify if:
- All patients who will need an anesthesia act in operating room during a 24 hours period
You may not qualify if:
- Patient opposition to participate in the study or parents opposition if the patient is a child or patient family opposition if the patient is not capable of being informed
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (83)
Centre Hospitalier de Cannes
Cannes, Alpes-Maritimes, 06400, France
Centre Hospitalier de Charleville-Mézières
Charleville-Mézières, Ardennes, 08000, France
Centre Hospitalier Jacques Puel
Rodez, Aveyron, 12000, France
CHU de Strasbourg - IHU
Strasbourg, Bas-Rhin, 67000, France
Hôpital La Timone (AP-HM)
Marseille, Bouches-du-Rhône, 13005, France
Hôpital Nord (AP-HM)
Marseille, Bouches-du-Rhône, 13015, France
CHU de Caen
Caen, Calvados, 14000, France
Centre Hospitalier Henri Mondor
Aurillac, Cantal, 15000, France
Groupe Hospitalier Littoral Atlantique
La Rochelle, Charente-Maritime, 17019, France
Centre Hospitalier de Brive-la-Gaillarde
Brive-la-Gaillarde, Corrèze, 19100, France
CHU de Dijon
Dijon, Côte d'Or, 21000, France
CHU Jean Minjoz
Besançon, Doubs, 25000, France
Centre Hospitalier de Valence
Valence, Drôme, 26000, France
Centre hospitalier Sud Francilien
Corbeil-Essonnes, Essonne, 91106, France
HIA Clermont Tonnerre
Brest, Finistère, 29240, France
CHRU de Brest
Brest, Finistère, 29609, France
Centre Hospitalier de Cornouailles
Quimper, Finistère, 29000, France
CHU de Nîmes
Nîmes, Gard, 30900, France
CHU de Bordeaux - Groupe hospitalier Pellegrin
Bordeaux, Gironde, 33000, France
Centre Hospitalier d'Arcachon
La Teste-de-Buch, Gironde, 33260, France
CHU de Bordeaux, Groupe Sud
Pessac, Gironde, 33600, France
Clinique mutualiste de Pessac
Pessac, Gironde, 33600, France
CHU de Limoges
Limoges, Haute Vienne, 87042, France
Clinique des Cèdres
Cornebarrieu, Haute-Garonne, 31700, France
Clinique la Croix du Sud
Quint-Fonsegrives, Haute-Garonne, 31130, France
Clinique de l'Union
Saint-Jean, Haute-Garonne, 31240, France
CHU de Toulouse - Hôpital Rangueil
Toulouse, Haute-Garonne, 31400, France
Centre Hospitalier Emile Roux
Le Puy-en-Velay, Haute-Loire, 43012, France
HIA Percy Clamart
Clamart, Hauts-de-Seine, 92141, France
Hôpital Marie Lannelongue
Le Plessis-Robinson, Hauts-de-Seine, 92350, France
CHU de Rennes - Pontchaillou
Rennes, Ille-et-Vilaine, 35033, France
CHU de Rennes - Hôpital Sud
Rennes, Ille-et-Vilaine, 35200, France
Clinique mutualiste La Sagesse
Rennes, Ille-et-Vilaine, 44345, France
CHU de Grenoble
Grenoble, Isère, 38100, France
CHU de la Réunion
Saint-Denis, La Réunion, 97400, France
Centre Hospitalier de Dax
Dax, Landes, 40100, France
Centre Hospitalier de l'Agglomération Montargoise
Amilly, Loiret, 45200, France
Clinique de l'Archette
Olivet, Loiret, 45160, France
CHU d'Angers
Angers, Maine-et-Loire, 49100, France
Institut Godinot
Reims, Marne, 51100, France
Institut de Cancérologie de Lorraine
Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54519, France
Groupe Hospitalier Bretagne Sud
Lorient, Morbihan, 56322, France
Centre Oscar Lambret
Lille, Nord, 59000, France
CHU de Lille - Institut coeur poumon
Lille, Nord, 59000, France
CHU de Lille - Hôpital Huriez
Lille, Nord, 59037, France
CHU de Lille - Hôpital Jeanne de Flandre
Lille, Nord, 59037, France
CHU de Lille - Hôpital Roger Salengro
Lille, Nord, 59037, France
Hôpital privé Arras les Bonnettes
Arras, Pas-de-Calais, 62000, France
Centre Hospitalier de Lens
Lens, Pas-de-Calais, 62300, France
CHU de Clermont-Ferrand
Clermont-Ferrand, Puy-de-Dôme, 63000, France
Clinique de la Plaine Santé
Clermont-Ferrand, Puy-de-Dôme, 63000, France
Clinique Aguilera
Biarritz, Pyrénées-Atlantiques, 64200, France
Centre Hospitalier de Pau
Pau, Pyrénées-Atlantiques, 64046, France
Hôpital mère-enfant (HCL)
Bron, Rhône, 69500, France
Hôpital Edouard Herriot
Lyon, Rhône, 69003, France
Centre Léon Bérard
Lyon, Rhône, 69008, France
Clinique de la Sauvegarde
Lyon, Rhône, 69009, France
CHU de Rouen
Rouen, Seine-Maritime, 76000, France
CHU d'Amiens
Amiens, Somme, 80054, France
Clinique Victor Pauchet
Amiens, Somme, 80090, France
Centre Hospitalier Intercommunal Castres-Mazamet
Castres, Tarn, France
Hôpital Nord Franche-Comté
Trévenans, Territoire De Belfort, 90400, France
Hôpital Privé de la Chataigneraie
Beaumont, Val d'Oise, 63110, France
Hôpital NOVO - Site de Beaumont-sur-Oise
Beaumont-sur-Oise, Val d'Oise, 95260, France
Hôpital NOVO - Site de Pontoise
Cergy-Pontoise, Val d'Oise, 90079, France
Institut Gustave Roussy
Villejuif, Val-de-Marne, 94805, France
Centre Hospitalier Intercommunal de Villeneuve Saint Georges
Villeneuve-Saint-Georges, Val-de-Marne, 94190, France
Sainte-Anne Military Teaching Hospital
Toulon, Var, 83000, France
Centre Hospitalier Intercommunal Toulon - La Seyne sur Mer
Toulon, Var, 83100, France
Hôpital Robert Schuman-Groupe UNEOS
Vantoux, Vaucluse, 57070, France
Centre Hospitalier Départemental de Vendée
La Roche-sur-Yon, Vendée, 85000, France
Hôpital Lariboisière (AP-HP)
Paris, 75010, France
Hôpital Saint Louis (AP-HP)
Paris, 75010, France
Hôpital Trousseau (AP-HP)
Paris, 75012, France
Hôpital La Pitié-Salpêtrière
Paris, 75013, France
Hôpital Européen Georges Pompidou
Paris, 75015, France
Groupe Hospitalier Diaconesses Croix Saint Simon
Paris, 75020, France
Hôpital Tenon (AP-HP)
Paris, 75020, France
Institut mutualiste Montsouris
Paris, 75674, France
Hôpital Paul Brousse (AP-HP)
Villejuif, 94800, France
CHU de Guadeloupe
Pointe-à-Pitre, 97159, Guadeloupe
Centre Hospitalier de Mayotte
Mamoudzou, 97600, Mayotte
Centre Hospitalier Princesse Grace
Monaco, 98000, Monaco
Related Publications (4)
McGain F, Muret J, Lawson C, Sherman JD. Environmental sustainability in anaesthesia and critical care. Br J Anaesth. 2020 Nov;125(5):680-692. doi: 10.1016/j.bja.2020.06.055. Epub 2020 Aug 12.
PMID: 32798068BACKGROUNDBarbariol F, Deana C, Lucchese F, Cataldi G, Bassi F, Bove T, Vetrugno L, De Monte A. Evaluation of Drug Wastage in the Operating Rooms and Intensive Care Units of a Regional Health Service. Anesth Analg. 2021 May 1;132(5):1450-1456. doi: 10.1213/ANE.0000000000005457.
PMID: 33667211BACKGROUNDMankes RF. Propofol wastage in anesthesia. Anesth Analg. 2012 May;114(5):1091-2. doi: 10.1213/ANE.0b013e31824ea491. Epub 2012 Mar 13.
PMID: 22415537BACKGROUNDRamstrom H, Martini S, Borgendahl J, Agerstrand M, Larfars G, Ovesjo ML. Pharmaceuticals and Environment: a web-based decision support for considering environmental aspects of medicines in use. Eur J Clin Pharmacol. 2020 Aug;76(8):1151-1160. doi: 10.1007/s00228-020-02885-1. Epub 2020 May 9.
PMID: 32388641BACKGROUND
Related Links
Study Officials
- STUDY DIRECTOR
Erwan D'Aranda, MD
Sainte-Anne Military Teaching Hospital (Hôpital d'instruction des armées Sainte Anne)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 2, 2022
First Posted
November 8, 2022
Study Start
April 6, 2023
Primary Completion
July 20, 2023
Study Completion
July 20, 2023
Last Updated
April 13, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will not share