Complementary Investigation of Perfusion and Anatomy Measures of the Heart With MRI and Combined PET/MRI

NCT05609214 | Recruiting

• 1 other identifier: 2021-02520
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to evaluate the complimentary information of anatomy, perfusion and viability of PET and MR. The main question\[s\] it aims to answer are:

• to compare perfusion and anatomy measurements and perfusion related signals from PET and MR imaging and estimate its prognostic values.
• to evaluate potential optimization of routine scanning procedure with regards to completeness and potential added value of quantitative measurements.

Conditions

Coronary Artery Disease

Keywords

Myocardial Perfusion

Outcome Measures

Primary Outcomes (1)

• Complimentary information on perfusion and metabolism

  To evaluate complimentary information on perfusion and metabolism assessed by PET and MR imaging to better identify individuals with known or suspected coronary artery disease

  2 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with known or suspected coronary artery disease who are referred for noninvasive cardiac evaluation, clinically indicated cardiac anatomy, viability and/or perfusion evaluation by MRI or PET scan

You may qualify if:

• Male and Female participants over the age of 18 years
• Written informed consent by the participant after information about the research project
• Symptoms consistent with possible coronary artery disease
• Clinical referral for a vasodilator stress CMR and/or PET examination

You may not qualify if:

• Patients with high degree heart block
• Contraindications to gadolinium-enhanced CMR examination
• Severe claustrophobia
• Specific implantable devices which are contraindicated for CMR
• Current pregnancy
• Advanced renal disease (GFR\<30)
• Uncontrolled obstructive pulmonary disease or asthma
• Atrial fibrillation at the time of study enrolment

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

University Hospital Zurich

Zurich, Switzerland

RECRUITING

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• Aju P Pazhenkottil

  University of Zurich

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Aju P Pazhenkottil, MD

CONTACT

+41792611965; aju.pazhenkottil@usz.ch

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 1, 2022
• First Posted: November 8, 2022
• Study Start: November 21, 2022
• Primary Completion: April 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: December 7, 2023

Record last verified: 2023-11

Locations

CH (1)