Study Stopped
Recruitment problems
Dynamic CT Myocardial Perfusion Imaging
Diagnostic Value and Practicability of Dynamic CT Stress and Rest Myocardial Perfusion Imaging in Daily Clinical Practice - A Monocentric Prospective Diagnostic Study
1 other identifier
interventional
43
1 country
1
Brief Summary
This study aims at evaluating the feasibility of CT myocardial perfusion imaging in daily clinical practice and compare it to SPECT perfusion imaging in order to assess sensitivity and specifity of CT myocardial perfusion imaging compared to SPECT.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable coronary-artery-disease
Started Sep 2015
Longer than P75 for not_applicable coronary-artery-disease
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2015
CompletedFirst Submitted
Initial submission to the registry
October 28, 2015
CompletedFirst Posted
Study publicly available on registry
November 2, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 28, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
September 28, 2021
CompletedOctober 6, 2021
September 1, 2021
6.1 years
October 28, 2015
September 28, 2021
Conditions
Outcome Measures
Primary Outcomes (1)
Validation of CT-MPI against SPECT-MPI
Sensitivity and specificity of CT-MPI to diagnose obstructive coronary artery disease using SPECTR-MPI as the standard reference
2 years
Secondary Outcomes (2)
Parameters influencing image quality of CT-MPI - Body physique
2 years
Parameters influencing image quality of CT-MPI - Heart rate
2 years
Study Arms (1)
CTP and SPECT-MPI
OTHEREvery patient enrolled will undergo CT-MPI and SPECT-MPI. The latter is clinically indicated,.
Interventions
Eligibility Criteria
You may qualify if:
- Referral for cardiac hybrid imaging with CCTA and SPECT
- Male and Female subjects 18 years of age or older,
- Written informed consent by the participant after information about the project
You may not qualify if:
- Contraindications for CCTA (including renal failure with a GFR \<60ml/min/1.73m2, allergies to ionidated constrast agents)
- Inability to follow the examination procedure due to language barriers, mental disease, dementia etc.
- Pregnancy or breast feeding
- Known allergies to iodinated contrast agent (Visipaque ®), 99mTc-Tetrofosmin (Myoview ®), betablockers (Beloc i.v. ®) or nitrates (Isoket -Spray®)
- Hypersensitivity to adenosine
- Asthma bronchiale
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Nuclear Medicine, University Hospital Zurich
Zurich, 8091, Switzerland
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ronny R Buechel, MD
University Hospital Zurich, Department of Nuclear Medicine
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 28, 2015
First Posted
November 2, 2015
Study Start
September 1, 2015
Primary Completion
September 28, 2021
Study Completion
September 28, 2021
Last Updated
October 6, 2021
Record last verified: 2021-09