Endothelial Glycocalyx Damage in Brain Death Organ Donors

NCT05609123 | Recruiting

• 1 other identifier: CooperatioUK_DBD_GCX
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program. By the description of the EG status, we can open room for organ optimization before transplantation and improve the organ function after transplantation in marginal donors.

Conditions

Brain Damage Due to Hypoxia; Organ Donors; Organ Transplant Failure or Rejection

Outcome Measures

Primary Outcomes (1)

• Markers of endothelial glycocalyx damage

  Levels of syndecan-1 in serum and urine

  baseline at the time of inclusion

Study Arms (1)

Brain dead organ donors

Patients with clinically proven bain death were assigned to the paraclinical confirmatory investigation of the brain death and subsequently accepted into the transplantation program.

Diagnostic Test: Endothelial glycocalyx damage assessment

Interventions

Endothelial glycocalyx damage assessment DIAGNOSTIC_TEST

Degradation products of endothelial glycocalyx will be assessed in the blood and urine.

Brain dead organ donors

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients in the intensive care unit with intracranial pathology are predisposed to brain death. In a time of confirmed brain death by clinical examination, the patients will be enrolled. Confirmatory paraclinical study of brain death is not mandatory for enrollment.

You may qualify if:

• patients in critical condition declared as brain dead by clinical examination

You may not qualify if:

• N/A

Sponsors & Collaborators

• University Hospital Hradec Kralove: lead

Study Sites (1)

University Hospital Hradec Kralove

Hradec Králové, 50005, Czechia

RECRUITING

MeSH Terms

Conditions

Hypoxia, Brain; Rejection, Psychology

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Hypoxia; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Social Behavior; Behavior

Central Study Contacts

David Astapenko, MD, PhD

CONTACT

+420495833218; david.astapenko@fnhk.cz

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy Head for Science and Research

Study Record Dates

• First Submitted: October 29, 2022
• First Posted: November 8, 2022
• Study Start: January 1, 2022
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: May 1, 2026

Record last verified: 2026-04

Locations

CZ (1)