Effect of Isocaloric Ketogenic Diet on Physical Performance at High Altitude
ICKD
Effect of a Four-week Isocaloric Ketogenic Diet on Physical Performance at Very High Altitude: a Pilot Study
1 other identifier
interventional
8
1 country
1
Brief Summary
A ketogenic diet (KD) reduces daily carbohydrates (CHOs) ingestion by replacing most calories with fat. KD is of increasing interest among athletes because it may increase their maximal oxygen uptake (VO2max), the principal performance limitation at high altitudes. The investigators examined the tolerance of a 4-week isocaloric KD (ICKD) under simulated hypoxia and the possibility of evaluating ICKD performance benefits with a maximal graded exercise bike test under hypoxia and collected data on the effect of the diet on performance markers and arterial blood gases.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Sep 2020
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
September 23, 2022
CompletedFirst Submitted
Initial submission to the registry
October 26, 2022
CompletedFirst Posted
Study publicly available on registry
November 3, 2022
CompletedNovember 3, 2022
October 1, 2022
1 year
October 26, 2022
October 31, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Performance test under hypoxic conditions
VO2max cycling test on ergometer
after 4 weeks of diet
Study Arms (2)
Normal diet
ACTIVE COMPARATORno limitations on food consumption.
Isocaloric ketogenic diet
EXPERIMENTALWe defined ICKD as a daily CHOs ingestion \< 30 to 50 g.d-1, without any limitation in fat consumption.
Interventions
The ICKD definition was based on the works of Sansone (2018) and Trimboli (2020). We defined ICKD as a daily CHOs ingestion \< 30 to 50 g.d-1, without any limitation in fat consumption. Participants self-selected their own diet based on a list of advised and forbidden foods developed to fit the definition of ICKD. There were no instructions to limit calories.
Eligibility Criteria
You may qualify if:
- Recreational mountaineers
- Familiarity with altitude (\>2500 m above sea level) and males/females 20 to 45 years old.
You may not qualify if:
- high training load (such as professional athletes) or new planned training
- dietary restrictions.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
CRR
Sion, 1951, Switzerland
Related Publications (1)
Chiarello N, Leger B, De Riedmatten M, Rossier MF, Vuistiner P, Duc M, Rapillard A, Allet L. Effect of a four-week isocaloric ketogenic diet on physical performance at very high-altitude: a pilot study. BMC Sports Sci Med Rehabil. 2023 Mar 20;15(1):37. doi: 10.1186/s13102-023-00649-9.
PMID: 36941621DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Lara Allet, PhD
HESso
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 26, 2022
First Posted
November 3, 2022
Study Start
September 1, 2020
Primary Completion
September 1, 2021
Study Completion
September 23, 2022
Last Updated
November 3, 2022
Record last verified: 2022-10
Data Sharing
- IPD Sharing
- Will not share