NCT05597579|Unknown
Cognitive Impairments in Psychotic Disorders
The Timing of Cognitive Impairments in Psychotic Disorders
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The Timing of Cognitive Impairments in Psychotic Disorders
Sponsor study identifier
observational
200
1 country
1
Study Start
February 12, 2020
Actual (reported)Primary Completion
May 1, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
May 1, 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Patients with Psychotic disorders (Schizophrenia, Bipolar disorder and Schizoaffective disorder) often suffer from significant cognitive impairments, however how these develop and change over time before and after the first psychotic break is unclear. While there are data by several groups, showing that many future patients have significant cognitive impairments years before the onset of psychosis, many future patients seem to be doing well before the manifestation of psychosis, and decline steeply in functioning after their first psychotic episode. Hence the timing of the onset of cognitive impairment in patients with psychotic disorders requires further exploration. The current study will investigate the timing of cognitive impairment by using IQ tests before and after the first psychotic break
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 1, 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 12, 2020
Actual (reported)February 24, 2022
Actual (reported)October 28, 2022
Actual (reported)May 1, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
May 1, 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Changes in DAPAR (An Israeli cognitive test) scores
Cognitive changes in both groups (lowest 10 - highest 90)
1 day (During recruitment visit)
Psychotic Symptoms
1 day (During recruitment visit)
Social Functioning
1 day (During recruitment visit)
Cognitive Functioning
1 day (During recruitment visit)
Coping strategies
1 day (During recruitment visit)
Patients diagnosed with psychotic disorder.
Healthy Controls
This study will compare DAPAR scores before and after the onset of the psychotic illness.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
The investigators will recruit patients treated in the psychiatric unit at the Sheba Medical Center and in other medical institutions throughout the country. Additionally, subjects will be recruited through internet advertisement of the study. All subjects will give informed consent. Control group will be recruited by matching for Age, Sex and socioeconomic status. recruitment will be preforemd by advertisement.
Sheba Medical Center
Ramat Gan, 52621, Israel
Mark Weiser, MD
Sheba Medical Center
First Submitted
February 24, 2022
First Posted
October 28, 2022
Study Start
February 12, 2020
Actual (reported)Primary Completion
May 1, 2023
Estimated (date passed)Use of Electrophysiological Markers to Predict Post-operative Cognitive Dysfunction
Contact the study team to confirm eligibility.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
May 1, 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
October 28, 2022
Record last verified: 2022-10
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Source: ClinicalTrials.gov.
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