The Effects of Different Outdoor Light Exposure Modes on Retinal Blood Flow

NCT05594732 | Completed

• 1 other identifier: YFZXLDX20220802
• Study Type: interventional
• Target: 81
• Locations: 1 country
• Sites: 1

Brief Summary

In 2020, the overall myopia rate among children and adolescents in my country was 52.7%. The COVID-19 pandemic has increased students' time of indoor eye-using, and it showed that the light exposure intensity of myopic students is lower than that of non-myopia students. Studies have found that the light wave bandwidth has a significant impact on the emmetropization of the eye, and white light can promote emmetropia more than monochromatic light. It shows that outdoor exercise has a protective effect on the occurrence and development of myopia in children and adolescents, but the specific mechanism is still unclear. Retinal blood flow is sensitive to myopic stimuli, and is a short-term indicator of the relationship between light environment and myopia. This study selected retinal blood flow as the primary outcome, aiming to compare the effects of different outdoor light exposure modes on retinal blood flow after 1 hour of intense eye use, and provide clues for the prevention and control of myopia.

Conditions

Myopia

Keywords

myopia; retinal blood flow; accommodative micro-fluctuation; outdoor light exposure

Outcome Measures

Primary Outcomes (1)

• Retinal blood flow density after relaxing for 15 minutes

  Data collected from Optovue AngioVue OCT (macular blood data collected) for the dominant eye. The duration of relaxing was recorded by a timer.

  Exposing to sunlight for 15 minutes

Secondary Outcomes (1)

• Retinal blood flow density changes between relaxing for 5 and 15 minutes

  Retinal blood flow density after relaxing for 5 and 15 minutes

Study Arms (2)

Weak outdoor light

EXPERIMENTAL

4000Lux natural light exposure

Behavioral: Weak outdoor light

Strong outdoor light

EXPERIMENTAL

10000Lux natural light exposure

Behavioral: Strong outdoor light

Interventions

Weak outdoor light BEHAVIORAL

Stay and stare far on the balcony or under the tree

Weak outdoor light

Strong outdoor light BEHAVIORAL

Stay and stare far in the sunlight

Strong outdoor light

Eligibility Criteria

• Age: 7 Years - 15 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• School students aged from 7 to 15, regardless of sex or gender;
• Diopter between -2.0D and 3.0D, and astigmatism not exceed 0.75D;
• No organic disease and in good general condition;
• Have obtained the consent of their parents or guardians, and can cooperate.

You may not qualify if:

• Suffering from amblyopia, strabismus, color weakness, congenital cataract, glaucoma and other eye diseases;
• Other circumstances judged by the investigator to be unsuitable to participate in the research.

Sponsors & Collaborators

• Shanghai Eye Disease Prevention and Treatment Center: lead

Study Sites (1)

Shanghai Eye Disease Prevention and Treatment Center

Shanghai, Shanghai Municipality, 200041, China

Location

Related Publications (5)

• Mirhajianmoghadam H, Pina A, Ostrin LA. Objective and Subjective Behavioral Measures in Myopic and Non-Myopic Children During the COVID-19 Pandemic. Transl Vis Sci Technol. 2021 Sep 1;10(11):4. doi: 10.1167/tvst.10.11.4.

  PMID: 34473223 BACKGROUND

• Rucker F. Monochromatic and white light and the regulation of eye growth. Exp Eye Res. 2019 Jul;184:172-182. doi: 10.1016/j.exer.2019.04.020. Epub 2019 Apr 21.

  PMID: 31018118 BACKGROUND

• Xiong S, Sankaridurg P, Naduvilath T, Zang J, Zou H, Zhu J, Lv M, He X, Xu X. Time spent in outdoor activities in relation to myopia prevention and control: a meta-analysis and systematic review. Acta Ophthalmol. 2017 Sep;95(6):551-566. doi: 10.1111/aos.13403. Epub 2017 Mar 2.

  PMID: 28251836 BACKGROUND

• Liu Y, Wang L, Xu Y, Pang Z, Mu G. The influence of the choroid on the onset and development of myopia: from perspectives of choroidal thickness and blood flow. Acta Ophthalmol. 2021 Nov;99(7):730-738. doi: 10.1111/aos.14773. Epub 2021 Feb 7.

  PMID: 33550704 BACKGROUND

• Zhao L, Zhang B, Wang J, Yang J, Du L, Wang T, Xu X, He X, Chen J. Short-term effects of sunlight exposure on fundus blood flow perfusion in children: a randomised controlled trial. Br J Ophthalmol. 2024 Dec 17;109(1):139-145. doi: 10.1136/bjo-2024-325715.

  PMID: 38981665 DERIVED

MeSH Terms

Conditions

Myopia

Condition Hierarchy (Ancestors)

Refractive Errors; Eye Diseases

Study Officials

• Xiangui He

  Shanghai Eye Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: The participants were randomly divided into two groups without knowing the exposing mode.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The participants were randomly divided into the following two groups: 1. 4000Lux natural light exposure; 2. 10000Lux natural light exposure.

Study Record Dates

• First Submitted: October 1, 2022
• First Posted: October 26, 2022
• Study Start: September 6, 2022
• Primary Completion: October 30, 2022
• Study Completion: October 30, 2022
• Last Updated: June 8, 2023

Record last verified: 2022-10

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)