The Effect of Antenatal Corticosteroid on Umbilical Artery Doppler Velocimetry in IUGR

NCT05588986 | Completed

• 1 other identifier: Antenatal-IUGR
• Study Type: observational
• Target: 149
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the effect of antenatal corticosteroid administration on umbilical artery Doppler velocimetry measurements in pregnancies complicated by IUGR.

Conditions

Intrauterine Growth Restriction

Outcome Measures

Primary Outcomes (3)

• systolic:diastolic ratio (S/D ratio)

  Peak systolic velocity/end diastolic velocity

  2018-2019

• pulsatility index (PI)

  Pulsatility Index (PI) = (Peak systolic velocity - end diastolic velocity)/(time averaged maximum velocity)

  2018-2019

• Resistive Index (RI)

  Resistive Index (RI) = (Peak systolic velocity - end diastolic velocity)/(peak systolic velocity)

  2018-2019

Study Arms (2)

with IUGR

Pregnant women who received antenatal corticosteroid therapy and complicated with intrauterine growth retardation

Other: ultrasonography

without IUGR

Pregnant women who received antenatal corticosteroid therapy and were not complicated by intrauterine growth retardation

Other: ultrasonography

Interventions

ultrasonography OTHER

Umbilical artery Doppler evaluation by ultrasonography just before the first dose of antenatal corticosteroid, 24 hours and 48 hours after the last dose.

with IUGR; without IUGR

Eligibility Criteria

• Age: 18 Years - 49 Years
• Sex: female
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Pregnant women treated with antenatal corticosteroid due to a possible preterm delivery were divided into two groups as complicated and uncomplicated with IUGR.

You may qualify if:

• pregnant women who were likely to have preterm delivery and were treated with antenatal corticosteroids.

You may not qualify if:

• Pregnant women who had complicated pregnancy with fetal anomaly, who had multiple pregnancies, who left their pregnancy follow-up unfinished, and those under 18 years of age were excluded from the study.

Sponsors & Collaborators

• Merve Demir: lead
• Marmara University: collaborator

Study Sites (1)

Merve Demir

Kocaeli, 41000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Fetal Growth Retardation

Interventions

High-Energy Shock Waves

Condition Hierarchy (Ancestors)

Fetal Diseases; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Growth Disorders; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Ultrasonic Waves; Sound; Radiation, Nonionizing; Radiation; Physical Phenomena

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Research assistant

Study Record Dates

• First Submitted: October 16, 2022
• First Posted: October 20, 2022
• Study Start: February 2, 2018
• Primary Completion: September 2, 2018
• Study Completion: February 2, 2019
• Last Updated: August 2, 2023

Record last verified: 2023-07

Locations

TU (1)