Comparison of Brachial Artery Dilatation, Uterine Artery Doppler, Umbilical Artery Doppler and 1st-trimester Visceral Adipose Tissue Measurement in Obese and Normal Pregnant Women

NCT04638504 | Completed

• 1 other identifier: DiyarbakirWCDH 3
• Study Type: observational
• Target: 240
• Locations: 1 country
• Sites: 1

Brief Summary

Brachial artery flow-mediated in obese and normal-weight pregnant women dilation of uterine artery doppler and umbilical artery doppler results comparison of

Conditions

Obese; Vascular Diseases; Pregnancy Related; Visceral Obesity

Outcome Measures

Primary Outcomes (4)

• To define the relationship between obesity and endovascular dysfunction by brachial artery dilatation method.

  To examine the possible effects of obesity on the endovascular system with the brachial artery dilation method.

  3 month

• Measurement of uterine artery doppler in obese and normal pregnant women

  To determine whether obesity has an effect on uterine artery resistance.

  3 month

• Measurement of obese and normal pregnant umbilical artery doppler

  trying to understand whether obesity has fetal effects by examining umbilical artery doppler in obese pregnants and normal pregnants,

  3 month

• First trimester visceral adipose tissue and brachial artery measurement

  By measuring the amount of visceral tissue in the first trimester obese and normal pregnant women with Armellini method; Investigation of its effects on endovascular dysfunction through brachial artery dilatation

  3 month

Study Arms (6)

11-14 weeks of normal pregnancy.

11-14. Measurement of brachial artery flow dilatation in the arm during pregnancy weeks, Visceral adipose tissue measurement (armellini method), and maternal uterine artery dopes will be examined ultrasonographically.

Other: ultrasonography

11-14 week obese pregnant

11-14. Measurement of brachial artery flow dilatation in the arm during pregnancy weeks, Visceral adipose tissue measurement (armellini method), and maternal uterine artery dopes will be examined ultrasonographically.

Other: ultrasonography

24-28 week normal pregnant

24-28. Measurement of brachial artery flow dilatation in the arm during pregnancy weeks, fetal umbilical artery, and maternal uterine artery dopes will be examined ultrasonographically.

Other: ultrasonography

24w-28w obese normal pregnant

24w-28w. Measurement of brachial artery flow dilatation in the arm during pregnancy weeks, fetal umbilical artery and maternal uterine artery dopes will be examined ultrasonographically

Other: ultrasonography

37w -40w normal pregant

37w-40 w. Measurement of brachial artery flow dilatation in the arm during pregnancy weeks, fetal umbilical artery and maternal uterine artery dopes will be examined ultrasonographically

Other: ultrasonography

37-40 w obese normal pregnant

37w-40 w. Measurement of brachial artery flow dilatation in the arm during pregnancy weeks, fetal umbilical artery and maternal uterine artery dopes will be examined ultrasonographically

Other: ultrasonography

Interventions

ultrasonography OTHER

vascular and adipose tissue measurement by ultrasonography

11-14 week obese pregnant; 11-14 weeks of normal pregnancy.; 24-28 week normal pregnant; 24w-28w obese normal pregnant; 37-40 w obese normal pregnant; 37w -40w normal pregant

Eligibility Criteria

• Age: 18 Years - 40 Years
• Gender Eligibility Details: pregnant
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

240

You may qualify if:

• obese and normal pregnant
• weeks
• weeks
• weeks

You may not qualify if:

• smoking
• chronic vascular disease
• Diabetes mellitus
• Over 40 years old

Sponsors & Collaborators

• Diyarbakir Women's and Children's Diseases Hospital: lead

Study Sites (1)

Diyarbakır Women's and Children's Hospital

Diyarbakır, 21100, Turkey (Türkiye)

Location

Related Publications (5)

• Adali E, Kurdoglu M, Adali F, Cim N, Yildizhan R, Kolusari A. The relationship between brachial artery flow-mediated dilatation, high sensitivity C-reactive protein, and uterine artery doppler velocimetry in women with pre-eclampsia. J Clin Ultrasound. 2011 May;39(4):191-7. doi: 10.1002/jcu.20781. Epub 2010 Dec 28.

  PMID: 21480285 BACKGROUND

• Takase B, Goto T, Hamabe A, Uehata A, Kuroda K, Satomura K, Ohsuzu F, Kurita A. Flow-mediated dilation in brachial artery in the second half of pregnancy and prediction of pre-eclampsia. J Hum Hypertens. 2003 Oct;17(10):697-704. doi: 10.1038/sj.jhh.1001599.

  PMID: 14504628 BACKGROUND

• Sierra-Laguado J, Garcia RG, Lopez-Jaramillo P. Flow-mediated dilatation of the brachial artery in pregnancy. Int J Gynaecol Obstet. 2006 Apr;93(1):60-1. doi: 10.1016/j.ijgo.2006.01.015. Epub 2006 Mar 9. No abstract available.

  PMID: 16527277 BACKGROUND

• Oliveira OP, Araujo Junior E, Lima JW, Salustiano EM, Ruano R, Martins WP, Costa Fda S. Flow-mediated dilation of brachial artery and endothelial dysfunction in pregnant women with preeclampsia: a case control study. Minerva Ginecol. 2015 Aug;67(4):307-13. Epub 2014 Dec 5.

  PMID: 25476264 BACKGROUND

• Parikh NI, Keyes MJ, Larson MG, Pou KM, Hamburg NM, Vita JA, O'Donnell CJ, Vasan RS, Mitchell GF, Hoffmann U, Fox CS, Benjamin EJ. Visceral and subcutaneous adiposity and brachial artery vasodilator function. Obesity (Silver Spring). 2009 Nov;17(11):2054-9. doi: 10.1038/oby.2009.60. Epub 2009 Mar 12.

  PMID: 19282819 BACKGROUND

MeSH Terms

Conditions

Obesity; Vascular Diseases; Obesity, Abdominal

Interventions

High-Energy Shock Waves

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Ultrasonic Waves; Sound; Radiation, Nonionizing; Radiation; Physical Phenomena

Study Officials

• Şeyhmus Tunç, MD

  Diyarbakır Gynecology Maternity and Pediatrics Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor of medicine

Study Record Dates

• First Submitted: October 18, 2020
• First Posted: November 20, 2020
• Study Start: November 19, 2020
• Primary Completion: February 27, 2021
• Study Completion: February 27, 2021
• Last Updated: March 2, 2021

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)