NCT05587569

Brief Summary

Prospective, multicenter, unblinded study to evaluate outcomes of the Adductoplasty™ Procedure in combination with the Lapiplasty® Procedure for patients in need of metatarsus adductus and hallux valgus correction. Up to 80 subjects will be treated in this study at up to 13 clinical sites. Patients 14 years of age or older with symptomatic metatarsus adductus and hallux valgus will be eligible to participate based on the inclusion and exclusion criteria defined in the study protocol.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for not_applicable

Timeline
57mo left

Started Sep 2022

Longer than P75 for not_applicable

Geographic Reach
1 country

9 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress44%
Sep 2022Dec 2030

Study Start

First participant enrolled

September 28, 2022

Completed
12 days until next milestone

First Submitted

Initial submission to the registry

October 10, 2022

Completed
10 days until next milestone

First Posted

Study publicly available on registry

October 20, 2022

Completed
4.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2030

Last Updated

May 25, 2025

Status Verified

May 1, 2025

Enrollment Period

4.3 years

First QC Date

October 10, 2022

Last Update Submit

May 22, 2025

Conditions

Keywords

Metatarsus AdductusHallux ValgusMTA3D

Outcome Measures

Primary Outcomes (1)

  • Radiographic recurrence of hallux valgus deformity with metatarsus adductus will be evaluated at 24 months for subjects wtih successful correction

    Successful correction is defined as two of the following three criteria: measured IMA \<9.0°, HVA \<15.0°, and TSP as ≤3 at 6 months post Adductoplasty® Procedure and Lapiplasty® Procedure. Recurrence at 24 months is defined by HVA \>15.0°.

    24 Months

Secondary Outcomes (11)

  • Radiographic Recurrence

    24 Months

  • Union vs non-Union

    12 Months

  • Clinical Complications

    60 Months

  • Weight-Bearing Recovery Time

    12 Months

  • Time to Weight-Bear in Boot

    6 Weeks

  • +6 more secondary outcomes

Interventions

Patients 14 years of age or older with symptomatic metatarsus adductus and hallux valgus will be eligible to participate based on the inclusion/exclusion criteria established in the study protocol. Anticipated study duration will be 5 years post index procedure.

Also known as: Adductoplasty™ Procedure in combination with the Lapiplasty® Procedure

Eligibility Criteria

Age14 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Male and females ≥14 years old at the time of consent
  • Closed physeal plates at the time of consent
  • Intermetatarsal angle is ≥8.0˚; OR True IMA of \>10°, (IMA+MTA-15=True IMA)
  • Hallux valgus angle is ≥12.0˚
  • Metatarsus adductus angle based on Sgarlatos method ≥15°
  • Willing and able to adhere to post-op care instructions
  • Capable of completing self-administered questionnaires
  • Acceptable surgical candidate, including use of general anesthesia
  • Female patients must be of non-childbearing potential or have a negative pregnancy test in accordance with hospital standards prior to the Index Procedure
  • Willing and able to schedule index procedure within 3 months of consent and able to return for scheduled follow-up visits
  • Willing and able to provide written informed consent
  • Patient agrees to refrain from any reconstructive procedures on contralateral foot for minimum of 6 months post index procedure

You may not qualify if:

  • Previous surgery for hallux valgus on operative side
  • Previous surgeries on operative foot involving fusion of foot or ankle joints (other than hammertoe, lesser toes/digits, or posterior muscle lengthening)
  • Moderate-severe osteoarthritis of the foot or ankle outside of the 1st, 2nd or 3rd tarsometatarsal joints
  • Severe osteoarthritis of the 1st, 2nd or 3rd tarsometatarsal joints
  • Any deformity of the hindfoot or midfoot that represents a pathological condition that may affect the outcome of the tarsometatarsal realignment, or a condition that requires concomitant surgical correction
  • BMI \>40 kg/m²
  • Current nicotine user in any form including vaping, smoking, oral ingestion or use of nicotine patch
  • Current clinical diagnosis of diabetes or currently taking medication for treatment of diabetes
  • Current clinical diagnosis of peripheral neuropathy
  • Current clinical diagnosis of fibromyalgia
  • Current clinical diagnosis of Complex Regional Pain Syndrome/Reflex Sympathetic Dystrophy (CRPS/RSD)
  • Current uncontrolled hypothyroidism
  • Current clinical diagnosis of chronic dependent edema
  • Previously sensitized to titanium
  • Currently taking oral steroids or rheumatoid biologics
  • +12 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (9)

Foot and Ankle Center of the Rockies

Greeley, Colorado, 80634, United States

RECRUITING

Foot and Ankle Center of Iowa

Ankeny, Iowa, 50023, United States

RECRUITING

Coastal Maine Foot and Ankle

Yarmouth, Maine, 04096, United States

RECRUITING

JCMG - Jefferson City Medical Group

Jefferson City, Missouri, 65019, United States

RECRUITING

Duke Orthopaedics Arringdon

Morrisville, North Carolina, 27560, United States

RECRUITING

Ohio Foot and Ankle Center

Canton, Ohio, 44708, United States

RECRUITING

Ohio Foot and Ankle Center

Stow, Ohio, 44224, United States

RECRUITING

Greater Pittsburgh Foot and Ankle Center

Wexford, Pennsylvania, 15090, United States

RECRUITING

Foot and Ankle Associates of North Texas - Keller

Keller, Texas, 76248, United States

RECRUITING

MeSH Terms

Conditions

Metatarsus VarusHallux Valgus

Condition Hierarchy (Ancestors)

Foot DeformitiesMusculoskeletal Diseases

Study Officials

  • Paul Dayton, DPM

    Foot and Ankle Center of Iowa

    PRINCIPAL INVESTIGATOR
  • Mark Easley, MD

    Duke University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 10, 2022

First Posted

October 20, 2022

Study Start

September 28, 2022

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2030

Last Updated

May 25, 2025

Record last verified: 2025-05

Data Sharing

IPD Sharing
Will not share

Locations