The Effect of Follicular Flushing on Oocyte Retrieval Rate and Embryo Quality

NCT05584436 | Active Not Recruiting

• 1 other identifier: 49829697
• Study Type: observational
• Target: 852
• Locations: 1 country
• Sites: 1

Brief Summary

Researchers will investigate the effect of flushing according to follicle size on the success of obtaining oocytes from a single follicle. In addition, by comparing the morphological quality of embryos developed from oocytes obtained with and without flushing, the possible effects of flushing on developing embryo quality will be investigated. By evaluating only one follicle for each patient, it is planned to investigate the effectiveness of the flushing process according to individual follicle characteristics, with a study design that has not yet been included in the literature.

Conditions

Infertility

Keywords

oocyte pick up; oocyte retrieval; follicle flushing

Outcome Measures

Primary Outcomes (3)

• Mean number of mature metaphase II oocytes

  Number of oocytes that have completed meiosis 1

  Through study completion, an average of 1 year

• Mean number of fertilized (2PN) oocytes

  Number of oocytes with two pronuclei

  Through study completion, an average of 1 year

• Mean number of high-quality blastocyst

  Number of embryos with \>2BB quality

  Through study completion, an average of 1 year

Study Arms (2)

oocytes obtained without flushing

First accessible follicle larger than 12 mm

oocytes obtained after flushing

Oocytes obtained after a total of 6 cc flushing of follicles that oocyte cumulus complex could not be obtained after the first aspiration

Eligibility Criteria

• Age: 18 Years - 43 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

All patients between the ages of 18-43 who will undergo OPU between June 2022 and March 2023 will be included in the study.

You may qualify if:

• Between 18-43 years old
• Patients who will undergo ICSI procedure

You may not qualify if:

• Patients who will undergo oocyte cryopreservation
• Patients with "empty follicle syndrome" in a previous OPU procedure
• Cases that OPU cannot be performed due to premature ovulation

Sponsors & Collaborators

• Akdeniz University: lead

Study Sites (1)

Akdeniz University

Antalya, 07700, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Infertility

Condition Hierarchy (Ancestors)

Genital Diseases; Urogenital Diseases

Study Officials

• ŞAFAK OLGAN, MD

  Akdeniz University

  PRINCIPAL INVESTIGATOR

• ARİF C ÖZSİPAHİ, MD

  Akdeniz University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: October 6, 2022
• First Posted: October 18, 2022
• Study Start: June 1, 2021
• Primary Completion: July 1, 2022
• Study Completion: September 1, 2024
• Last Updated: July 12, 2024

Record last verified: 2024-07

Locations

TU (1)