Factors Associated With Success of NIPPV in ALS Patients

NCT05581771 | Completed

• 1 other identifier: B-2210-786-107
• Study Type: observational
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

This is a retrospective cohort study to assess the factor associated with success of non-invasive positive ventilation in ALS patients.

Conditions

ALS

Keywords

Noninvasive positive pressure ventilation; Amyotrophic lateral sclerosis; Adherence

Outcome Measures

Primary Outcomes (1)

• Success of NIPPV

  The success of NIPPV application was defined empirically as use of ≥ 2 hours per day and the failure as use of \< 2 hours for a day or conversion to invasive positive pressure ventilation via tracheostomy or refuse to apply NIPPV during hospitalization.

  through intervention completion, with an average of 10 days

Secondary Outcomes (1)

• Lenght of stay

  through intervention completion, with an average of 10 days

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

ALS patients who were admitted for applying non-invasive positive pressure ventilation initially.

You may qualify if:

• Patients fulfilling the El Escorial World Federation criteria for probable, or definite ALS
• Aged ≥ 19 years
• Patients who performed blood gas analysis including venous blood gas and arterial blood gas before NIPPV application.

You may not qualify if:

• Patients who had experience in applying the NIPPV or currently using NIPPV
• Patients who applied in outpatient settings
• Patients who did not perform blood gas analysis before NIPPV application
• Patietns who had a history of asthma or COPD,
• Patients who didn't have any record of NIPPV application time

Sponsors & Collaborators

• Seoul National University Bundang Hospital: lead

Study Sites (1)

Seoul National University Bundang Hospital

Seongnam-si, 13620, South Korea

Location

MeSH Terms

Conditions

Amyotrophic Lateral Sclerosis

Condition Hierarchy (Ancestors)

Spinal Cord Diseases; Central Nervous System Diseases; Nervous System Diseases; Motor Neuron Disease; Neurodegenerative Diseases; TDP-43 Proteinopathies; Neuromuscular Diseases; Proteostasis Deficiencies; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Jaewon Beom, PhD

  Department of Rehabilitation Medicine, Seoul National University Bundang Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Associate Professor

Study Record Dates

• First Submitted: October 4, 2022
• First Posted: October 17, 2022
• Study Start: October 18, 2022
• Primary Completion: October 27, 2022
• Study Completion: October 4, 2023
• Last Updated: July 16, 2024

Record last verified: 2024-07

Locations

KR (1)