Key Insights

Highlights

Success Rate

77% trial completion

Published Results

19 trials with published results (18%)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 59/100

Termination Rate

13.1%

14 terminated out of 107 trials

Success Rate

77.0%

-9.5% vs benchmark

Late-Stage Pipeline

7%

7 trials in Phase 3/4

Results Transparency

40%

19 of 47 completed with results

Key Signals

19 with results77% success14 terminated

Data Visualizations

Phase Distribution

72Total
Not Applicable (30)
P 1 (20)
P 2 (15)
P 3 (7)

Trial Status

Completed47
Recruiting23
Terminated14
Unknown10
Not Yet Recruiting7
Withdrawn3

Trial Success Rate

77.0%

Benchmark: 86.5%

Based on 47 completed trials

Clinical Trials (107)

Showing 20 of 20 trials
NCT05568615Phase 3CompletedPrimary

Extension Study Following the Studies MT-1186-A03 or A04 to Evaluate the Safety of Oral Edaravone in Subjects With ALS

NCT04165824Phase 3CompletedPrimary

Safety Study of Oral Edaravone Administered in Subjects With ALS

NCT05151471Phase 3TerminatedPrimary

Efficacy and Safety Extension Study of Oral Edaravone Administered in Subjects With ALS

NCT04569084Phase 3TerminatedPrimary

Efficacy and Safety Study of Oral Edaravone Administered in Subjects With ALS

NCT05966038RecruitingPrimary

ALS/MND Natural History Study Data Repository

NCT06735014Recruiting

Multicenter ALS Imaging Study

NCT07543367Not ApplicableRecruiting

INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study

NCT03698149Not ApplicableRecruitingPrimary

ECoG BMI for Motor and Speech Control

NCT04396873Phase 1Recruiting

PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

NCT07446114Not ApplicableRecruiting

Functional Outcomes and Control Using Synchron BCI - Canada

NCT06665165Phase 1RecruitingPrimary

AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis

NCT05602142Phase 1Not Yet RecruitingPrimary

Study of [11C]CPPC as a Clinical PET Radioligand Biomarker of Microglial Activation in ALS

NCT06453668Phase 1RecruitingPrimary

A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patients

NCT05377424Phase 1Active Not RecruitingPrimary

Adenosine 2A Receptor Antagonism and AIH in ALS

NCT06513546Phase 1Not Yet Recruiting

A Study to Evaluate the Safety, Efficacy, and Pharmacodynamics of PLL001 in ALS Patients

NCT06743776UnknownPrimary

Scalable Expanded Access With Analysis of Neurofilament and Other Biomarkers for Ibudilast in ALS

NCT07460037Not ApplicableRecruiting

Chinese-Specific Speech Imagery Coding Using High-Density ECoG

NCT03268603Phase 2Active Not RecruitingPrimary

Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis (ALS)

NCT07341334Not Yet Recruiting

Digital Speech Markers for Monitoring ALS in Spanish Speakers

NCT05271435Active Not RecruitingPrimary

Digital Tools for Assessment of Motor Functions and Falls in ALS

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