Key Insights

Highlights

Success Rate

77% trial completion

Published Results

19 trials with published results (17%)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 72/100

Termination Rate

13.8%

15 terminated out of 109 trials

Success Rate

76.6%

-10.0% vs benchmark

Late-Stage Pipeline

6%

7 trials in Phase 3/4

Results Transparency

39%

19 of 49 completed with results

Key Signals

19 with results77% success15 terminated

Data Visualizations

Phase Distribution

73Total
Not Applicable (30)
P 1 (20)
P 2 (16)
P 3 (7)

Trial Status

Completed49
Recruiting21
Terminated15
Unknown9
Not Yet Recruiting8
Active Not Recruiting4

Trial Success Rate

76.6%

Benchmark: 86.5%

Based on 49 completed trials

Clinical Trials (109)

Showing 20 of 20 trials
NCT06735014Recruiting

Multicenter ALS Imaging Study

NCT07739134Active Not Recruiting

Multimodal Tracking of Therapy Activity and Effort During Rehabilitation

NCT07400393Not Yet RecruitingPrimary

Healey ALS MyMatch Common Screening Protocol

NCT05568615Phase 3CompletedPrimary

Extension Study Following the Studies MT-1186-A03 or A04 to Evaluate the Safety of Oral Edaravone in Subjects With ALS

NCT04165824Phase 3CompletedPrimary

Safety Study of Oral Edaravone Administered in Subjects With ALS

NCT04569084Phase 3TerminatedPrimary

Efficacy and Safety Study of Oral Edaravone Administered in Subjects With ALS

NCT06453668Phase 1TerminatedPrimary

A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patients

NCT07193953Phase 1Active Not Recruiting

Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS)

NCT07688239Phase 2Not Yet Recruiting

The BANYAN Trial, an ALS MyMatch Trial Evaluating Safety, Biomarker Activity, and Microglial Activation of Nasal Foralumab

NCT04396873Phase 1Recruiting

PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

NCT04259255Completed

Radicava® (Edaravone) Findings in Biomarkers From ALS (REFINE-ALS)

NCT05271435CompletedPrimary

Digital Tools for Assessment of Motor Functions and Falls in ALS

NCT02795052Not ApplicableRecruiting

Neurologic Stem Cell Treatment Study

NCT06511934Not ApplicableRecruiting

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)

NCT05151471Phase 3TerminatedPrimary

Efficacy and Safety Extension Study of Oral Edaravone Administered in Subjects With ALS

NCT05966038RecruitingPrimary

ALS/MND Natural History Study Data Repository

NCT07543367Not ApplicableRecruiting

INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study

NCT03698149Not ApplicableRecruitingPrimary

ECoG BMI for Motor and Speech Control

NCT07446114Not ApplicableRecruiting

Functional Outcomes and Control Using Synchron BCI - Canada

NCT06665165Phase 1RecruitingPrimary

AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis

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Research Network

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