Association of a Digital Signature of Physical Activity and Sedentary Lifestyle With the Development of Multimorbidities in Chronic Diseases (eMOB)

NCT05578495 | Recruiting

• 2 other identifiers: RBHP 2021 TOURNADRE2021-A01967-34
• Study Type: interventional
• Target: 700
• Locations: 1 country
• Sites: 1

Brief Summary

Physical activity (PA) and sedentary lifestyle are determinants in the development of chronic diseases and associated quality of life alterations. PA levels are correlated with quality of life and morbidity in chronic lung disease (COPD), cardiovascular disease, diabetes, cancer, chronic inflammatory rheumatism, fibromyalgia and anxiety disorders. In these diseases, low-intensity PA often represents the main PA and the quantity of PA is correlated with health parameters. This study aims to identify a typical profile (signature) in relation to the appearance of other chronic diseases, complications of your disease, from recording your physical activity and sedentary lifestyle by sensors evaluating very precisely the movements and taking into account the characteristics and disability related to your disease. The results of this study would therefore make it possible to identify this signature even before the appearance of complications or other diseases.

Conditions

Exercise; Sedentary Behavior; Non Communicable Diseases; Comorbidities and Coexisting Conditions; Comorbidity; Multimorbidity; Digital Technology

Keywords

Physical Activity; Sedentary Lifestyle; Chronic Diseases; Comorbidities; Multimorbidity; Personal digital health; Personalized medecine

Outcome Measures

Primary Outcomes (2)

• Occurrence of one additional comorbidity in patients with chronic diseases.

  Association of a digital signature of PA and sedentary lifestyle with the development of at least one additional comorbidity over 4 years of follow-up.

  year 4

• Digital signature of sedentary lifestyle and PA in patients with chronic diseases.

  A sensor of movement will be worn by the patients for 5 days every 4 months during the study, to detect and quantify the physical activity and the sedentarity according to their intensity. This sensor will be accelerometer, allowing the acquisition of movements second by second. The analysis of the data from the sensors, the occurrence of a new comorbidity, the clinical data will allow to establish an algorithm to define a profile (digital signature) of occurrence of a new chronic disease.

  Year 4

Secondary Outcomes (20)

• Occurence of multimorbidity in patients with chronic diseases.

  Year 1

• Occurence of multimorbidity in patients with chronic diseases.

  year 2

• Occurence of multimorbidity in patients with chronic diseases.

  Year 3

• Occurence of multimorbidity in patients with chronic diseases.

  Yaer 4

• Correlation of PA/sedentary signature with destabilization or improvement/stability of the chronic condition.

  Year 1

Study Arms (1)

Chronic diseases

OTHER

Cohort Study

Other: Accelerometer data

Interventions

Accelerometer data OTHER

Patients will wear an accelerometer 3 times a year for 5 days (3 weekdays and 2 weekend days), the data will be collected

Chronic diseases

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient follow-up at CHU Clermont-Ferrand for a chronic disease in one of the following observational cohorts:
• Inflammatory rheumatic disease(rheumatoid arthritis, spondyloarthritis) included in the RCVRIC cohort (CPP Sud-Est VI N° ID-RCB- A01847-40)
• Pre-surgical knee and hip osteoarthritis (Evalmob) (ID-RCB N° 2019- A01017-50)
• Major depressive disorder included in the FACE-DR cohort (CNIL agreement: DR- 2015-673) and Bipolar disorder included in the FACE-BD cohort (CPP Ile de France IX; January 18, 2010) of the Adult Psychiatry Department B
• Type 2 diabetes included in the cohort of the sport medicine service "Rehabilitation T2" (CNIL agreement 0164)
• Obesity included in the "Obesity" sports medicine service cohort (CNIL agreement 0164)
• COPD included in the "COPD Rehabilitation" sports medicine service cohort (CNIL agreement 0164)
• Chronic pain cohort (eDOL) (CPP West II N° ID-RCB 2020-A02027-32)
• Affiliation to a social security system.
• Able to provide written informed consent to participate in the research.

You may not qualify if:

• Inability to practice physical activity
• Pregnant or breastfeeding
• Refusal to participate
• Minors or adults under the protection of the law or under the protection of justice.

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead

Study Sites (1)

CHU de Clermont-Ferrand

Clermont-Ferrand, 63000, France

RECRUITING

MeSH Terms

Conditions

Motor Activity; Sedentary Behavior; Noncommunicable Diseases; Chronic Disease

Condition Hierarchy (Ancestors)

Behavior; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Anne Tournadre

  University Hospital, Clermont-Ferrand

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Lise LACLAUTRE

CONTACT

+33473754963; promo_interne_drci@chu-clermontferrand.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 19, 2022
• First Posted: October 13, 2022
• Study Start: December 7, 2023
• Primary Completion (Estimated): December 1, 2030
• Study Completion (Estimated): December 1, 2030
• Last Updated: September 24, 2025

Record last verified: 2025-09

Locations

FR (1)