Efficacy of Pilocarpine 1% in Presbyopia
1 other identifier
interventional
25
1 country
1
Brief Summary
In this before-after interventional study on patients with presbyopia after cataract surgery, uncorrected distance vision and corrected distance visual acuity are measured and recorded by Snellen chart. Corrected near visual acuity from a distance of 40 cm is measured by the standard near vision chart (Rosenbaum near vision card). Twenty minutes after the administration of pilocarpine 1%, the corrected near and far visual acuity is measured again. Also, the relationship between the difference in average near visual acuity after the administration of 1% pilocarpine in pseudophakic people is measured with iris color and pupil size.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_3
Started Jul 2022
Shorter than P25 for phase_3
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2022
CompletedFirst Submitted
Initial submission to the registry
October 10, 2022
CompletedFirst Posted
Study publicly available on registry
October 13, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
March 30, 2023
CompletedOctober 13, 2022
October 1, 2022
6 months
October 10, 2022
October 10, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Best Corrected Near Visual Acuity
Comparison of the BCNVA before and after instillation of Pilocarpine 1%
20 minutes
Secondary Outcomes (1)
Best Corrected Distance Visual Acuity
20 minutes
Study Arms (1)
Pilocarpine
EXPERIMENTAL1 drop of Pilocarpine 1% instill in the eye
Interventions
Eligibility Criteria
You may qualify if:
- Informed consent to participate in the study
- Previous uncomplicated cartaract surgery and PCIOL insertion
- BCDVA eqaul to or more than 8/10
- Less than 1.5 diopter cylindrical refractive error
- Spherical refractive error between -0.5\_+1.5
- No history of previous eye disease
- Not using drugs that interact with pilocarpine
You may not qualify if:
- Occurrence of any drug-related complications
- Unable to follow up the patient after prescribing the drug
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Isfahan Eye Research Center
Isfahan, 81746-73461, Iran
Related Publications (1)
Peyman A, Naderi-Lordejani M, Irajpour M, Ghanbarnia MJ, Koosha N, Pourazizi M. Pilocarpine 1% for Improved Near Vision in Pseudophakic Patients. J Ophthalmic Vis Res. 2025 May 19;20:10.18502/jovr.v20.15331. doi: 10.18502/jovr.v20.15331. eCollection 2025.
PMID: 40689127DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Alireza Peyman, M.D.
Isfahan University of Medical Sciences, Isfahan, Iran
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- NA
- Masking
- NONE
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr. Alireza Peyman
Study Record Dates
First Submitted
October 10, 2022
First Posted
October 13, 2022
Study Start
July 1, 2022
Primary Completion
December 30, 2022
Study Completion
March 30, 2023
Last Updated
October 13, 2022
Record last verified: 2022-10