Interpersonal Psychotherapy for Adolescents and Young Adults

NCT05575960 | Recruiting

• 1 other identifier: 2022-00983
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the project is to study the effectiveness of Interpersonal Psychotherapy (IPT) for adolescents with depression. Specific aims are to analyze the effects, change mechanisms, predictors, and implementation of IPT for youth. In this four-year project we will include 60 patients with depression. Outcome will be studied using a quasi-experimental multiple-baseline design. Change mechanisms will be studied in the form of mentalizing, emotion regulation, social support, and working alliance session-by-session, and with post-treatment qualitative interviews about the participants' experiences of change. Predictors of effectiveness of IPT for adolescents will be explored by measuring severity of symptoms, anxiety symptoms, presence and severity of parent-child conflicts, quality of interpersonal relationships, experiences of bullying, and school functioning. The implementation process of IPT for youth will be studied through interviews with adolescents, parents, therapists, co-workers, and local managers. The study is conducted within child and adolescent psychiatric services in Norrköping using a practice-oriented research strategy which emphasizes close collaboration with clinicians. The project is a collaboration between researchers at Linnaeus University and Linköping University, and clinicians at BUP Norrköping.

Conditions

Major Depression

Outcome Measures

Primary Outcomes (2)

• Patient Health Questionnaire - 9 for depression/Eating Disorder Inventory - Very Short for eating disorder patients

  Patient-rated depression/eating disorder severity. Scale from 0-27 points, with higher scores indicating more severe symptoms.

  Change from treatment start to week 12 compared to change from before waiting-list to treatment start. In the multiple baseline design, the time for the waiting list varies, in this case about 4-25 weeks.

• Montgomery Åsberg Depression Rating Scale (observer version) for depression/Eating Disorder Inventory for eating disorders

  Depression/eating disorder severity measures. Scale from 0-60 points, with higher scores indicating more severe symptoms..

  Change from treatment start to week 12 compared to change from before waiting-list to treatment start. In the multiple baseline design, the time for the waiting list varies, in this case about 4-25 weeks.

Study Arms (1)

Interpersonal Psychotherapy

EXPERIMENTAL

Interpersonal Psychotherapy for Adolescents according to the manual by Mufson (2004). Mufson, L. (2004). Interpersonal psychotherapy for depressed adolescents. Guilford Press.

Behavioral: Interpersonal Psychotherapy for Adolescents (IPT-A)

Interventions

Interpersonal Psychotherapy for Adolescents (IPT-A) BEHAVIORAL

Interpersonal Psychotherapy (IPT) is a psychotherapeutic treatment originally developed for treating depression in adults. It is a brief, structured treatment based on the idea of mobilizing the patient's social network, increasing his/her capacity to accept and seek support from others, and to process interpersonal difficulties, in order to improve depressive symptoms. Interpersonal psychotherapy for adolescents (IPT-A) is a version of IPT designed for young people between the age of 12-18 years with depression (Mufson, 2004), and is in many respects similar to IPT although with some modifications (e.g., a few scheduled meetings with parents during the course of treatment).

Interpersonal Psychotherapy

Eligibility Criteria

• Age: 15 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Major depressive disorder according to the DSM-V
• Age 15 to 17,5 years.
• Good-enough knowledge in Swedish to be able to read instructions in questionnaires and who do not require an interpreter.

You may not qualify if:

• Ongoing psychosis
• Drug or alcohol addiction
• Bipolar disorder
• Suspected mental retardation
• Acute suicidality or severe depression requiring hospitalization
• Patients who have started antidepressant medication within the last six weeks will need to wait until medication effects have stabilized.

Sponsors & Collaborators

• Linnaeus University: lead
• Linkoeping University: collaborator

Study Sites (1)

Norrköping Child and Adolescent Psychiatric Services (BUP Norrköping)

Norrköping, Sweden

RECRUITING

MeSH Terms

Conditions

Depressive Disorder, Major

Interventions

Interpersonal Psychotherapy

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Psychotherapy; Behavioral Disciplines and Activities

Study Officials

• Fredrik Falkenström, PhD

  Linnaeus University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Fredrik Falkenström, PhD

CONTACT

+46701089877; fredrik.falkenstrom@lnu.se

Liselott Lindegren

CONTACT

Liselott.Lindegren@regionostergotland.se

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: Not possible to mask psychotherapy for patient or therapist.
• Purpose: TREATMENT
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Clinical Psychology

Model Details: Multiple Baseline Design

Study Record Dates

• First Submitted: October 4, 2022
• First Posted: October 12, 2022
• Study Start: October 3, 2022
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): June 15, 2027
• Last Updated: May 20, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)