A Danish Nationwide Longitudinal Study on Prevalence of Periodontitis and Its Co-morbidities

NCT05574231 | Unknown

• 1 other identifier: 522-0018/22-3800
• Study Type: observational
• Target: 4,000,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

The project (PlanPerioMed) is a register-based study evaluating the associations and patterns of health care delivery between periodontitis and medical diseases using data from the Danish dental record system Dentalsuite (Plandent A/S) and national Danish health care registries with three overall hypotheses/ aims:

• Determine the extent to which periodontitis in registry data is associated with more odontological treatment services and treatment frequency.
• Determine if patients with systemic diseases attend dentists more frequently and receive more treatment services per patient than the population without these diseases.
• Determine to which extent periodontitis and received periodontal treatment affects the risk of medical diseases. The study will focus on association and trajectories of periodontitis and its treatment with three medical diseases, namely, Type 2 Diabetes Mellitus (Type 2 DM), Cardiovascular Diseases (CVD) and Rheumatoid Arthritis (RA). The dataset consists of approximately 4,000,000 people aged between 18 and 99 years attending private practice in Denmark. The results from PlanPerioMed study are likely to have ramifications for treatment guidelines for other periodontitis comorbidities, e.g. CVD and DM, and will thereby improve the quality of life for a wide range of patients and reduce long-term societal health care expenses related to periodontitis and its comorbidities.

Conditions

Periodontitis; Diabetes Mellitus, Type 2; Cardiovascular Diseases; Rheumatoid Arthritis

Keywords

Periodontal Diseases, Periodontal Index, Periodontal Bone Loss, Periodontal Attachment Loss, Probing Depth, Bleeding on Probing, Clinical Attachment Loss; Diabetes Mellitus 2, DM type 2, Non-insulin dependent diabetes mellitus, Uncontrolled diabetes mellitus type 2, Increased blood glucose level; CVD, Cardiovascular risk, Heart disease, Heart disease risk factors; Smoking status, Socio-economic status, Register based, Longitudinal study, Danish nationwide study, systemic diseases

Outcome Measures

Primary Outcomes (3)

• Treatment frequency and type of treatment services

  Number of treatment and odontological treatment services due to periodontitis

  25 years

• Treatment frequency and type of treatment services among patients with medical diseases

  Number of treatment and odontological treatment services among patients with medical diseases due to periodontitis

  25 years

• Effect on medical diseases

  Risk of medical diseases based on periodontal disease extent and received periodontal treatment

  25 years

Interventions

Periodontal treatment PROCEDURE

It includes surgical and non-surgical procedures depending on patient as well as tooth level.

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study population will include people who are clinically diagnosed with periodontal diseases and private practice dental care attenders in Denmark.

You may qualify if:

• Subjects with clinical registrations of DMFT, periodontal status and corresponding treatment codes
• Self-reported systemic diseases including Diabetes Mellitus Type 2, Cardiovascular Diseases and Rheumatoid Arthritis
• Subjects with Clinical Attachment Loss\>=3mm, Probing Depth \>= 3mm and bleeding on probing (as defined by World Workshop 2017- criteria for periodontitis) in clinical examination will be included in the study population.

You may not qualify if:

• Subjects with more than 32 teeth
• Subjects with no clinical registrations

Sponsors & Collaborators

• University of Copenhagen: lead
• Plandent A/S: collaborator

Related Publications (6)

• Kongstad J, Ekstrand K, Qvist V, Christensen LB, Cortsen B, Gronbaek M, Holm-Pedersen P, Holmstrup P, Bardow A, Twetman S, Fiehn NE. Findings from the oral health study of the Danish Health Examination Survey 2007-2008. Acta Odontol Scand. 2013 Nov;71(6):1560-9. doi: 10.3109/00016357.2013.776701. Epub 2013 Apr 29.

  PMID: 23627881 BACKGROUND

• Kongstad J, Enevold C, Christensen LB, Fiehn NE, Holmstrup P. Impact of Periodontitis Case Criteria: A Cross-Sectional Study of Lifestyle. J Periodontol. 2017 Jun;88(6):602-609. doi: 10.1902/jop.2017.160426. Epub 2017 Jan 27.

  PMID: 28128681 BACKGROUND

• Hansen GM, Egeberg A, Holmstrup P, Hansen PR. Relation of Periodontitis to Risk of Cardiovascular and All-Cause Mortality (from a Danish Nationwide Cohort Study). Am J Cardiol. 2016 Aug 15;118(4):489-93. doi: 10.1016/j.amjcard.2016.05.036. Epub 2016 May 30.

  PMID: 27372888 BACKGROUND

• Holmstrup P, Damgaard C, Olsen I, Klinge B, Flyvbjerg A, Nielsen CH, Hansen PR. Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician. J Oral Microbiol. 2017 Jun 14;9(1):1332710. doi: 10.1080/20002297.2017.1332710. eCollection 2017.

  PMID: 28748036 BACKGROUND

• Hansen PR, Holmstrup P. Cardiovascular Diseases and Periodontitis. Adv Exp Med Biol. 2022;1373:261-280. doi: 10.1007/978-3-030-96881-6_14.

  PMID: 35612803 BACKGROUND

• Joseph R, Rajappan S, Nath SG, Paul BJ. Association between chronic periodontitis and rheumatoid arthritis: a hospital-based case-control study. Rheumatol Int. 2013 Jan;33(1):103-9. doi: 10.1007/s00296-011-2284-1. Epub 2012 Jan 7.

  PMID: 22228465 BACKGROUND

Related Links

• Related Info

MeSH Terms

Conditions

Periodontitis; Diabetes Mellitus, Type 2; Cardiovascular Diseases; Arthritis, Rheumatoid; Periodontal Diseases; Alveolar Bone Loss; Periodontal Attachment Loss; Heart Diseases

Interventions

Periodontal Index

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases; Bone Resorption; Bone Diseases; Periodontal Atrophy

Intervention Hierarchy (Ancestors)

Dental Health Surveys; Health Surveys; Surveys and Questionnaires; Data Collection; Epidemiologic Methods; Investigative Techniques; Dentistry; Periodontics; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Public Health Dentistry

Study Officials

• Anne Havemose Poulsen

  Head of Department

  STUDY DIRECTOR

Central Study Contacts

Christian Damgaard

CONTACT

+4525323832; chrd@sund.ku.dk

Simranjit Kaur

CONTACT

+4531545565; simranjit.kaur@sund.ku.dk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 25 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor, Head of Section

Study Record Dates

• First Submitted: September 1, 2022
• First Posted: October 10, 2022
• Study Start: November 1, 2022
• Primary Completion: December 1, 2025
• Study Completion: December 31, 2025
• Last Updated: October 10, 2022

Record last verified: 2022-10

Data Sharing

• IPD Sharing: Will not share