Treatment of Periodontal Disease in Patients With Acute Myocardial Infarction

NCT02543502 | Completed

• 1 other identifier: UP nº 4742. 12
• Study Type: interventional
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

The main objective of this study is to evaluate the effect of treatment periodontal endothelium-dependent artery of the arm in patients with acute myocardial infarction with ST-segment elevation undergoing primary coronary intervention.

Conditions

Periodontitis

Keywords

Periodontitis; atherosclerosis; Heart Disease

Outcome Measures

Primary Outcomes (1)

• The difference in dilation measured by brachial artery blood flow

  The primary outcome will be the difference in the dilation measured through the flow in the brachial artery by the end of six months.

  6 months

Secondary Outcomes (1)

• Major cardiovascular events

  6 months

Other Outcomes (1)

• Bacteremia

  24 hours

Study Arms (2)

periodontal treatment

EXPERIMENTAL

Group will receive treatment: periodontal treatment

Procedure: periodontal treatment

Control Group.

NO INTERVENTION

Group will not receive treatment: periodontal treatment

Interventions

periodontal treatment PROCEDURE

treatment of periodontal cleaning

periodontal treatment

Eligibility Criteria

• Age: 30 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients admitted to our institution with a diagnosis of AMI (ST segment elevation\> 0.1mV)
• older than 30 years
• with more than 8 teeth in the mouth
• with advanced periodontal disease

You may not qualify if:

• acute or chronical infection
• impossibility of attending the following interviews and/or the periodontal treatment
• refusing to signing the consent form
• individuals with substance abuse
• anticonvulsants and immunosuppressant drugs users
• pregnant and \\ or lactating women.

Sponsors & Collaborators

• Instituto de Cardiologia do Rio Grande do Sul: lead
• Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil: collaborator
• Conselho Nacional de Desenvolvimento Científico e Tecnológico: collaborator

Study Sites (1)

Instituto de Cardiologia do Rio Grande do Sul

Porto Alegre, Rio Grande do Sul, Brazil

Location

Related Publications (29)

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  PMID: 31810741 DERIVED

MeSH Terms

Conditions

Periodontitis; Atherosclerosis; Heart Diseases

Interventions

Periodontal Index

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Dental Health Surveys; Health Surveys; Surveys and Questionnaires; Data Collection; Epidemiologic Methods; Investigative Techniques; Dentistry; Periodontics; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Public Health Dentistry

Study Officials

• Alexandre Sc Quadros, Phd

  Instituto de Cardiologia do Rio Grande do Sul, IC-FUC

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 27, 2015
• First Posted: September 7, 2015
• Study Start: August 1, 2012
• Primary Completion: January 1, 2015
• Study Completion: January 1, 2015
• Last Updated: September 7, 2015

Record last verified: 2015-09

Locations

BR (1)