Early Oral Feeding for Patients After Pancreaticoduodenectomy

NCT05573399 | Completed

• 1 other identifier: ChanghaiH-PP11
• Study Type: observational
• Target: 440
• Locations: 1 country
• Sites: 1

Brief Summary

This study intends to retrospectively analyze the patients who underwent pancreatoduodenectomy and compare the safety and feasibility between early enteral nutrition through nasojejunal tube and early oral feeding after pancreatoduodenectomy. This study is expected to revise the guidelines for early nutritional support after pancreaticoduodenectomy, reduce postoperative complications, and provide better guidance for clinical work.

Conditions

Pancreatoduodenectomy

Outcome Measures

Primary Outcomes (1)

• Perioperative complications

  Complications defined by ISGPS in perioperative period

  From Operation date to three months after operation

Study Arms (2)

Early oral feeding

No enteral feeding tube was placed after pancreaticoduodenectomy and oral nutrition was given early. Patients were given liquid drinks on the second day after pancreaticoduodenectomy, and solid food from the fifth day.

Early nasojejunal enteral nutrition

Early enteral nutrition was given early through nasojejunal tube. 5% glucose saline was given on the first day after pancreaticoduodenectomy through nasojejunal tube. Enteral nutrition was given from the second day after pancreaticoduodenectomy. When oral intake was adequate, the nasojejunal tube was removed on the sixth day.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who underwent pancreaticoduodenectomy in Changhai Hospital.

You may qualify if:

• Patients who underwent pancreaticoduodenectomy by a certain surgeon in Changhai Hospital
• Patients who were treated with nasojejunal enteral nutrition or oral enteral nutrition after operation.

You may not qualify if:

• Patients who underwent pancreaticoduodenectomy by other surgeons during the same period;
• Patients who received other nutritional support rather than nasojejunal tube enteral nutrition or oral enteral nutrition after operation.

Sponsors & Collaborators

• Changhai Hospital: lead

Study Sites (1)

Changhai Hospital

Shanghai, Shanghai Municipality, China

Location

Related Publications (1)

• Jing W, Wu S, Gao S, Shi X, Liu W, Ren Y, Ouyang L, Zheng K, Guo S, Wu C, Jin G. Early oral feeding versus nasojejunal early enteral nutrition in patients following pancreaticoduodenectomy: a propensity score-weighted analysis of 428 consecutive patients. Int J Surg. 2024 Jan 1;110(1):229-237. doi: 10.1097/JS9.0000000000000786.

  PMID: 37755371 DERIVED

Study Officials

• Gang Jin, Doctor

  Changhai Hospital, Shanghai, China

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant of Hepatobiliary and Pancreatic Surgery

Study Record Dates

• First Submitted: October 7, 2022
• First Posted: October 10, 2022
• Study Start: August 1, 2018
• Primary Completion: December 31, 2020
• Study Completion: December 31, 2021
• Last Updated: October 18, 2022

Record last verified: 2022-10

Locations

CN (1)