NCT05571254|Completed
The Management of Transient Loss of Consciousness and Suspected Syncope in European Emergency Departments
SEED
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SEED
Sponsor study identifier
observational
952
18 countries
57
Study Start
September 12, 2022
Actual (reported)Primary Completion
December 2, 2022
Actual (reported)Study Completion
December 2, 2022
Actual (reported)Prospective multi centre cohort study examining the clinical presentation, diagnostic tests, and management of adult Emergency Department (ED) patients presenting with Transient Loss of Consciousness (TLOC) either undifferentiated or thought to be of syncopal origin.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2, 2022
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 12, 2022
Actual (reported)September 26, 2022
Actual (reported)October 7, 2022
Actual (reported)December 2, 2022
Actual (reported)December 2, 2022
Actual (reported)Participant age
Participant age
Admission
Participant gender
Participant gender
Admission
Mode of arrival
Mode of arrival
Admission
Referral source
Referral source
Admission
Presence of any European Society of Cardiology (ESC) syncope high-risk history features
Which European Society of Cardiology syncope high-risk history features are present
Admission
ESC high-risk 'past medical history' features
Which European Society of Cardiology syncope high-risk 'past medical history' features are present
All patients will have a focussed Case Report Form completed collecting routine data describing the prevalence, clinical presentation, assessment, management and ESC risk category of patients, at the time or shortly after the patients ED attendance.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Adults 18 years of age and older presenting to the ED over a two-week period with TLOC, either undifferentiated or thought to be of syncopal origin.
Regional Hospital Durres
Durrës, Albania
Regional Hospital Centre "Xh. Kongoli" Elbasan
Elbasan, Albania
Spitali "Petro Nako" Sarandra
Sarandë, Albania
Regional Hospital Shkoder
Shkoder, Albania
University Hospital Centre "Mother Theresa" Tirana
Tirana, Albania
Allgemeines Krankenhaus der Stadt Wien/ Universitätskliniken
Vienna, Austria
Klinik Donaustadt
Vienna, Austria
Vaittinada Ayar P, Kearns D, Vaittinada Ayar P, Laribi S. Effect of sex on syncope management in European emergency departments: the European Society for Emergency Medicine Research network Syncope in European Emergency Departments study. Eur J Emerg Med. 2026 Jun 1;33(3):197-202. doi: 10.1097/MEJ.0000000000001294. Epub 2026 Apr 27. No abstract available.
Reed MJ, Karuranga S, Kearns D, Alawiye S, Clarke B, Mockel M, Karamercan M, Janssens K, Riesgo LG, Torrecilla FM, Golea A, Fernandez Cejas JA, Lupan-Muresan EM, Zaimi E, Nuernberger A, Rennet O, Skjaerbaek C, Polyzogopoulou E, Imecz J, Groff P, Camilleri R, Cimpoesu D, Jovic M, Miro O, Anderson R, Laribi S; SEED investigators. Management of syncope in the Emergency Department: a European prospective cohort study (SEED). Eur J Emerg Med. 2024 Apr 1;31(2):136-146. doi: 10.1097/MEJ.0000000000001101. Epub 2023 Nov 27.
Matt Reed
University of Edinburgh
952 participants (actual enrollment reported by the registry).
First Submitted
September 26, 2022
First Posted
October 7, 2022
Study Start
September 12, 2022
Actual (reported)Admission
Other medical comorbidities
Other medical comorbidities
Admission
Rockwood Clinical Frailty Scale score
Rockwood Clinical Frailty Scale is a well validated score ranging from 1 (Very Fit) to 9 (Terminally Ill) with defined descriptions for each category.
Admission
ESC high risk 'physical examination' factors
ESC high risk 'physical examination' factors
Admission
Blood pressure (BP) on admission
First Blood pressure (BP) measure in the Emergency Department in mmHg
Admission
Pulse rate on admission
First pulse rate measured in the Emergency Department in beats per minute
Admission
Lying/standing systolic BP difference on admission
First lying/standing systolic BP difference measured in the Emergency Department in mmHg
Admission
Number of participants with abnormal Electrocardiogram (ECG) readings
Number of participants with abnormal ECG readings
Admission
Troponin levels
Troponin levels
Admission
D-dimer levels
D-dimer levels
Admission
Copeptin levels
Copeptin levels
Admission
Natriuretic peptides levels
Natriuretic peptides levels
Admission
ED clinician diagnosis
ED clinician diagnosis - descriptive
Admission
Patient destination
Descriptive options: Admitted to Observation/Clinical Decision Unit/Same Day Emergency Care unit/hospital floor with telemetry monitoring/hospital floor with no telemetry monitoring. Discharged to outpatient follow up/family doctor/General Practitioner care/home with no follow up
Admission
Reason(s) for admission
Reason(s) for admission
Admission
Whether driving and occupation advice given
Whether driving and occupation advice given
Admission
Status at discharge from hospital
Status at discharge from hospital
30 days
Length of hospital stay in days
Length of hospital stay in days
30 days
Hospital discharge diagnosis
Hospital discharge diagnosis
30 days
Contact the study team to confirm eligibility.
AZ Sint Jan Brugge
Bruges, Belgium
AZ Alma Eeklo
Eeklo, Belgium
Ghent University Hospital
Ghent, Belgium
Heilig Hartziekenhuis Lier
Lier, Belgium
University Hospital Hradec Králové
Králová, Czechia
University Hospital Královské Vinohrady
Prague, Czechia
Regionshospitalet Gødstrup
Herning, Denmark
Nordsjællands Hospital
Hillerød, Denmark
Regionshospitalet Randers
Randers, Denmark
Sjællands Universitetshospital
Roskilde, Denmark
Regionshospitalet Midt
Vildbjerg, Denmark
Kanta-Häme Central Hospital
Helsinki, Finland
CHU Besançon
Besançon, France
CHU Caen
Caen, France
CHU Clermond-Ferrand
Clermont-Ferrand, France
Medipole
Lyon, France
CHU Tours
Tours, France
University General Hospital ATTIKON
Athens, Greece
General Hospital Venizeleio
Heraklion, Greece
AHEPA Univesrity General Hospital of Thessaloniki
Thessaloniki, Greece
Semmelweis University Department of Emergency Medicine
Budapest, Hungary
ED Azienda Ospedaliera Universitaria di Bologna (Sant'Orsola Hospital)
Bologna, Italy
ED Azienda Ospedaliera-universitaria di Catania (San Marco Hospital)
Catania, Italy
ED Azienda USL Toscana Centro, Firenze (San Giovanni di Dio Hospital)
Florence, Italy
Azienda Ospedaliera di Perugia (Santa Maria Della Misericordia Hospital)
Perugia, Italy
ED Azienda Ospedaliera-Universitaria integrata (Borgo Trento Hospital)
Verona, Italy
Mater Dei Hospital
Birkirkara, Malta
Gozo General Hospital
Victoria, Malta
St. Olav's University Hospital
Trondheim, Norway
Wroclaw University Hospital
Wroclaw, Poland
Cluj Napoca County Emergency Clinical Hospital
Cluj-Napoca, Romania
Saint Spiridon County Hospital
Iași, Romania
Emergency Center Belgrade, Clinical Centre Belgade
Belgrade, Serbia
Clinical Centre of Niš
Niš, Serbia
Emergency Department Zaječar, Health Center Zaječar
Zaječar, Serbia
Hospital Dr. Balmis
Alicante, Spain
Hospital clinic Barcelona
Barcelona, Spain
Hospital de Terrassa
Barcelona, Spain
Hospital Universitari de Bellvitge
Barcelona, Spain
Hospital Universitari de Vic
Barcelona, Spain
Gazi University Medical Faculty Department of Emergency Medicine
Ankara, Turkey (Türkiye)
Medical Science University Ankara Education and Research Hospital Department of Emergency Medicine
Ankara, Turkey (Türkiye)
Karamanoglu Mehmetbey University Karaman Education and Research Hospital Department of Emergency Medicine
Karaman, Turkey (Türkiye)
Necmettin Erbakan University Medical Faculty Department of Emergency Medicine
Konya, Turkey (Türkiye)
Medical Science University Sanliurfa Mehmet Akif Inan Education and Research Hospital Department of Emergency Medicine
Sanliurfa, Turkey (Türkiye)
Royal Infirmary of Edinburgh
Edinburgh, Midlothian, EH16 4SA, United Kingdom
University Hospital Coventry & Warwickshire
Coventry, United Kingdom
Victoria Hospital
Kirkcaldy, United Kingdom
St Johns Hospital, Livingston
Livingston, United Kingdom
Royal Preston Hospital
Preston, United Kingdom
Primary Completion
December 2, 2022
Actual (reported)Study Completion
December 2, 2022
Actual (reported)Last Updated
March 23, 2023
Record last verified: 2022-09
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Source: ClinicalTrials.gov.
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