NCT05563740

Brief Summary

Alcohol Use Disorders (AUD) form a major public health issue in India. In a densely populated country with limited mental health resources, it is challenging to treat those with AUD appropriately. Detoxification is the first step in dealing with clinically significant AUD. Institution based detoxification is not universally available and home based detoxification is mired with poor outcomes with people resuming drinking behaviour. This trail therefore aimed to study the effect of a psychosocial intervention to improve the outcome of domiciliary alcohol detoxification. The intervention involved Brief Interventions for alcohol and daily telephone monitoring and psychosocial support of patients undergoing home detoxification.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jan 2020

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2020

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2020

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2020

Completed
1.7 years until next milestone

First Submitted

Initial submission to the registry

September 23, 2022

Completed
10 days until next milestone

First Posted

Study publicly available on registry

October 3, 2022

Completed
Last Updated

October 3, 2022

Status Verified

September 1, 2022

Enrollment Period

9 months

First QC Date

September 23, 2022

Last Update Submit

September 28, 2022

Conditions

Alcohol Use Disorder

Keywords

Alcohol withdrawalHome detoxificationDomiciliary Detoxification

Outcome Measures

Primary Outcomes (1)

  • Succesful Detoxification

    Proportion of participants successfully completing detoxification as indicated by CIWA score of less than 8

    Up to four weeks

Secondary Outcomes (1)

  • Abstinence at one month

    One month

Study Arms (2)

Intervention Group

EXPERIMENTAL

All received care for alcohol withdrawal state as is routinely provided at the centre by their respective treating doctors and followed up as directed. All treatment and follow up decisions were made by the respective treating doctors. Study team did not have any role in it. In addition all received a session of Brief Intervention (BI) for alcohol, at the time of recruitment and again after completing detoxification. Further, patient or designated caregiver received daily phone calls and Information was provided regarding any queries related to their withdrawal or detoxification process. Adverse outcomes such as sedation, seizure, confusion were enquired for and records were kept. Patient was encouraged to continue the treatment and report back for scheduled follow ups and in case of any adverse outcomes patient was asked to report back to the treating doctor and an appointment was facilitated. Phone calls were discontinued once detoxification (CIWA \< 8) was complete.

Other: Psychosocial

Control Group

NO INTERVENTION

All participants received care for alcohol withdrawal state as is routinely provided at the centre by their respective treating doctors and followed up as directed. All treatment and follow up decisions were made by the respective treating doctors. Study team did not have any role in it.

Interventions

PsychosocialOTHER

Daily telephone calls with two sessions of Brief Interventions for alcohol

Intervention Group

Eligibility Criteria

Age18 Years - 65 Years
Sexmale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may not qualify if:

  • Nil

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Institue of Psychiatry & Human Behaviour

Bambolim, Goa, 403202, India

Location

Related Publications (19)

  • Manthey J, Shield KD, Rylett M, Hasan OSM, Probst C, Rehm J. Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study. Lancet. 2019 Jun 22;393(10190):2493-2502. doi: 10.1016/S0140-6736(18)32744-2. Epub 2019 May 7.

    PMID: 31076174BACKGROUND

  • National Collaborating Centre for Mental Health (UK). Alcohol-Use Disorders: Diagnosis, Assessment and Management of Harmful Drinking and Alcohol Dependence. Leicester (UK): British Psychological Society (UK); 2011. Available from http://www.ncbi.nlm.nih.gov/books/NBK65487/

    PMID: 22624177BACKGROUND

  • GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16;390(10100):1345-1422. doi: 10.1016/S0140-6736(17)32366-8.

    PMID: 28919119BACKGROUND

  • 4. Hammer JH, Parent MC, Spiker DA, World Health Organization. Global status report on alcohol and health 2018 [Internet]. Vol. 65, Global status report on alcohol. 2018. 74-85 p. Available from: http://www.who.int/substance_abuse/publications/global_alcohol_report/msbgsruprofiles.pdf%0Ahttp://www.ncbi.nlm.nih.gov/pubmed/29355346

    BACKGROUND

  • Rastogi A, Manthey J, Wiemker V, Probst C. Alcohol consumption in India: a systematic review and modelling study for sub-national estimates of drinking patterns. Addiction. 2022 Jul;117(7):1871-1886. doi: 10.1111/add.15777. Epub 2022 Jan 10.

    PMID: 34873774BACKGROUND

  • Nadkarni A, Velleman R, Bhatia U, Fernandes G, D'souza E, Murthy P. Home-detoxification and relapse prevention for alcohol dependence in low resource settings: An exploratory study from Goa, India. Alcohol. 2020 Feb;82:103-112. doi: 10.1016/j.alcohol.2019.08.006. Epub 2019 Aug 29.

    PMID: 31473304BACKGROUND

  • Nemlekar S, Gaonkar P, Rane A. Domiciliary alcohol detoxification outcomes: a study from Goa, India. J Addict Dis. 2021 Jan-Mar;39(1):105-108. doi: 10.1080/10550887.2020.1826103. Epub 2020 Oct 20.

    PMID: 33079007BACKGROUND

  • 8. The Mental Health Care Act 2017. Available from: http://www.prsindia.org/uploads/media/Mental%20Health/Mental%20Healthcare%20Act,%202017.pdf

    BACKGROUND

  • D'Souza PC, Mathai PJ. Motivation to change and factors influencing motivation in alcohol dependence syndrome in a tertiary care hospital. Indian J Psychiatry. 2017 Apr-Jun;59(2):183-188. doi: 10.4103/psychiatry.IndianJPsychiatry_262_15.

    PMID: 28827865BACKGROUND

  • Johnson PR, Britto C, Sudevan KJ, Bosco A, Sreedaran P, Ashok MV. Resilience in Wives of persons with Alcoholism: An Indian exploration. Indian J Psychiatry. 2018 Jan-Mar;60(1):84-89. doi: 10.4103/psychiatry.IndianJPsychiatry_271_14.

    PMID: 29736068BACKGROUND

  • Baby S, Murthy P, Thennarasu K, Chand PK, Viswanath B. Comparative outcome in patients with delirium tremens receiving care in emergency services only versus those receiving comprehensive inpatient care. Indian J Psychiatry. 2017 Jul-Sep;59(3):293-299. doi: 10.4103/psychiatry.IndianJPsychiatry_260_17.

    PMID: 29085087BACKGROUND

  • Gupta A, Murthy P, Rao S. Brief screening for cognitive impairment in addictive disorders. Indian J Psychiatry. 2018 Feb;60(Suppl 4):S451-S456. doi: 10.4103/psychiatry.IndianJPsychiatry_41_18.

    PMID: 29540913BACKGROUND

  • Gulati P, Chavan BS, Sidana A. Authors' reply to commentary on "Gulati P, Chavan BS, Sidana A. Comparative efficacy of baclofen and lorazepam in the treatment of alcohol withdrawal syndrome". Indian J Psychiatry. 2019 Nov-Dec;61(6):652-653. doi: 10.4103/psychiatry.IndianJPsychiatry_325_19. No abstract available.

    PMID: 31896877BACKGROUND

  • Sullivan JT, Sykora K, Schneiderman J, Naranjo CA, Sellers EM. Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar). Br J Addict. 1989 Nov;84(11):1353-7. doi: 10.1111/j.1360-0443.1989.tb00737.x.

    PMID: 2597811BACKGROUND

  • Prochaska JO, Velicer WF. The transtheoretical model of health behavior change. Am J Health Promot. 1997 Sep-Oct;12(1):38-48. doi: 10.4278/0890-1171-12.1.38.

    PMID: 10170434BACKGROUND

  • 18. Waters AF. Readiness to change and smoking expectancies among adult male substance users currently in substance use treatment by. 2020;(December).

    BACKGROUND

  • Timko C, Below M, Schultz NR, Brief D, Cucciare MA. Patient and program factors that bridge the detoxification-treatment gap: a structured evidence review. J Subst Abuse Treat. 2015 May;52:31-9. doi: 10.1016/j.jsat.2014.11.009. Epub 2014 Dec 3.

    PMID: 25530425BACKGROUND

  • Sarkar S, Pakhre A, Murthy P, Bhuyan D. Brief Interventions for Substance Use Disorders. Indian J Psychiatry. 2020 Jan;62(Suppl 2):S290-S298. doi: 10.4103/psychiatry.IndianJPsychiatry_778_19. Epub 2020 Jan 17. No abstract available.

    PMID: 32055071BACKGROUND

  • Hjorthoj CR, Hjorthoj AR, Nordentoft M. Validity of Timeline Follow-Back for self-reported use of cannabis and other illicit substances--systematic review and meta-analysis. Addict Behav. 2012 Mar;37(3):225-33. doi: 10.1016/j.addbeh.2011.11.025. Epub 2011 Nov 26.

    PMID: 22143002BACKGROUND

MeSH Terms

Conditions

Alcoholism

Condition Hierarchy (Ancestors)

Alcohol-Related DisordersSubstance-Related DisordersChemically-Induced DisordersMental Disorders

Study Officials

  • Anil Rane

    IPHB

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Principle Investigator

Study Record Dates

First Submitted

September 23, 2022

First Posted

October 3, 2022

Study Start

January 1, 2020

Primary Completion

September 30, 2020

Study Completion

December 31, 2020

Last Updated

October 3, 2022

Record last verified: 2022-09

Data Sharing

IPD Sharing
Will not share

Locations

IN(1)