Efficacy of Phonophoresis With Topical Glyceryl Trinitrate in Treatment of Achilles Tendinopathy

NCT05561959 | Completed

• 1 other identifier: P.T.REC/012
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of study is to investigate the effect of Phonophoresis with topical glyceryl trinitrate versus traditional treatment in in patients with non-insertional Achilles tendinopathy.

Conditions

Non Insertional Achilles Tendinopathy

Keywords

Achilles tendinopathy; phonophoresis; topical glyceryl trinitrate

Outcome Measures

Primary Outcomes (3)

• the change in thickness of Achilles tendon

  measured by Ultrasonography.

  at first week and after 12 week of treatment

• the change in Pain in patients with non-insertional Achilles tendinopathy.

  measured by Visual Analog Scale

  at first week and after 12 week of treatment

• the change in Functional performance

  measured by vertical countermovement jump test.

  at first week and after 12 week of treatment

Study Arms (2)

Phonophoresis Group

EXPERIMENTAL

Phonophoresis with topical glyceryl trinitrate traditional therapy three times a week for four week

Other: topical glyceryl trinitrate gel

Eccentric exercises Group

ACTIVE COMPARATOR

eccentric exercises three times a week for four weeks

Other: Eccentric exercises

Interventions

topical glyceryl trinitrate gel OTHER

topical nitroglycerin medication were treated with 1 gr nitroglycerin 2% gel

Phonophoresis Group

Eccentric exercises OTHER

stretching exercises of the gastrocnemius (straight leg) and soleus (bended knee).

Eccentric exercises Group

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 20-50 years old
• The diagnosis was based on pain located in the Achilles tendon for at least 3 months.
• Pain in the Achilles tendon area with distinct tenderness of the tendon 2 to 6 cm above the Achilles tendon insertion on the calcaneus
• Ultrasonographic changes defined as local thickening of the symptomatic tendon, irregular tendon structure and fiber orientation, and separated tendon fibers or a globally more than 2 mm thicker tendon on the sick side
• Diffuse pain in the posterior region of the ankle with local tenderness of the Achilles tendon and ultrasonographic changes.

You may not qualify if:

• Symptoms of \<3 months, previous surgery, previous ankle dislocation, distal neurology, steroid injections in last 3 month, pregnancy, and contraindication to GTN
• Treatment of achillodynia with stretching or eccentric training for more than 2 weeks within the last 2 years
• Other injuries in the lower extremity or the knee, which by the examining doctor was evaluated to influence the evaluation of symptoms or the ability to perform the training program
• Acute symptoms with ultrasonographic changes consistent with a partial rupture of the tendon

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Faculty of physical therapy Cairo university

Giza, 338772, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer of physical therapy Basic Science department faculty of physical therapy

Model Details: Randomized controlled clinical trial

Study Record Dates

• First Submitted: September 19, 2022
• First Posted: September 30, 2022
• Study Start: November 1, 2022
• Primary Completion: February 1, 2023
• Study Completion: April 1, 2023
• Last Updated: September 28, 2023

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)