Effects of Multicomponent Training on Inflammation Parameters and Muscle Quality in Elderly Obese Woman

NCT05552677 | Unknown

• 1 other identifier: Exercise_Inflammation
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

Population aging worldwide has increased substantially in recent years. In order to prevent disabling diseases and improve the quality of life, it is necessary to understand the conditions related to the health of this specific population. One of the known alterations that occur in the body is the increased low-grade systemic inflammatory process, anabolic resistance, and muscle catabolism. These conditions can negatively interfere with muscle quality and functionality. However, the maintenance of the metabolic and physical functionality of muscle tissue can be preserved by performing physical exercises throughout life because of its anti-inflammatory mechanisms. In the present study, a multicomponent training program that combines aerobic, strength, balance, and flexibility capacities was used. The hypothesis is that performing this type of physical exercise will mitigate meta-inflammation and its negative effects, in addition to stimulating anabolic signals and reducing insulin resistance present in anabolic resistance, leading to improved quality and muscle functionality in elderly women with obesity.

Conditions

Aging Disorder; Obesity; Inflammation

Keywords

anabolic resistance; obesity; inflammation; physical exercise

Outcome Measures

Primary Outcomes (2)

• Changes in inflamatory markers

  Evaluate the inflamatory markers PCR, IL-1β, IL-6, IL-10, IL-15, TNF-α, NFκβ, NLRP3, myonectin, SIRT1, sTNFR1, IL-10, IL-13, adiponectin

  12 weeks

• Changes in muscle quality

  Evaluate the quantity of intramuscular fat deposits trough ultrasound pre and post intervention

  12 weeks

Secondary Outcomes (9)

• Changes in muscle function

  12 weeks

• Changes in metabolic parameters - fasting blood glucose

  12 weeks

• Changes in metabolic parameters - insulin sensitivity

  12 weeks

• Changes in muscle remodeling peptides

  12 weeks

• Body composition changes

  12 weeks

Study Arms (2)

Control Group (CG)

NO INTERVENTION

Patients will recieve no intervention for the period of 12 weeks

Exercise Group (EG)

EXPERIMENTAL

Patients will undergo a 12 week multicomponent training program

Other: Multicomponent Training

Interventions

Multicomponent Training OTHER

Participants will perform a multicomponent training that explores strength, aerobic and balance capacities with load progression every 15 days. The sessions will last 60 minutes each, being held three times a week with a day of rest in between. The intervention will last 12 weeks

Exercise Group (EG)

Eligibility Criteria

• Age: 60 Years - 75 Years
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• BMI between 30 and 40kg/m²;

You may not qualify if:

• alcoholics
• smokers
• diseases that prevents the practice of physical activity
• medical impediment to the practice of physical exercise throughout the study
• infectious diseases
• coronary diseases
• chronic kidney diseases
• chronic use of corticosteroids
• chronic use of immunomodulators
• undergoing nutritional monitoring or weight loss treatment
• score ≤13 for cognitive screening on the Mini-Mental State Examination (MMSE)

Sponsors & Collaborators

• University of Sao Paulo: lead

Study Sites (1)

University of São Paulo, School of Physical Education and Sports of Ribeirão Preto

Ribeirão Preto, São Paulo, 14048-900, Brazil

RECRUITING

Related Publications (1)

• Travieso SG, Ortiz GU, Abud GF, Villalba MM, Junqueira GP, Gomes MM, Marchini JS, Freitas EC. Effects of Multicomponent Training on Metabolic and Functional Health of Older Women With Obesity: A Randomized Clinical Trial. J Aging Phys Act. 2025 Aug 26:1-13. doi: 10.1123/japa.2024-0341. Online ahead of print.

  PMID: 40858281 DERIVED

MeSH Terms

Conditions

Obesity; Inflammation; Motor Activity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes; Behavior

Study Officials

• Ellen C de Freitas, PhD

  University of São Paulo, School of Physical Education and Sports of Ribeirão Preto.

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sofia G Travieso, Specialist

CONTACT

16988084179; sofia.travieso@usp.br

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Randomized Clinical Trial

Study Record Dates

• First Submitted: September 15, 2022
• First Posted: September 23, 2022
• Study Start: August 1, 2022
• Primary Completion: November 1, 2022
• Study Completion: December 30, 2022
• Last Updated: September 23, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)