IPSC Repository of Pediatric Cardiovascular Disease

NCT05550324 | Recruiting

• 1 other identifier: STUDY00001788
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Obtain blood samples for generation and maintenance of induced pluripotent stem cells (iPSCs) and genomic/DNA sequencing for biomedical research that will improve the understanding and treatment of pediatric cardiovascular disease

Conditions

Congenital Heart Disease; Heart Diseases

Keywords

iPSC

Outcome Measures

Primary Outcomes (1)

• improve the understanding and treatment of pediatric cardiovascular disease

  This is a repository of blood samples that will be used into the future for medical research to improve the understanding and treatment of pediatric cardiovascular disease

  up to 10 Years

Study Arms (4)

Affected Subjects

The subjects must have the diagnosis of cardiovascular disease

Procedure: Blood draw

Syndromes associated with Cardiovascular Disease

The subject must have a syndrome associated with cardiovascular disease

Procedure: Blood draw

Family Members

The subject must be related to an individual in cohort 1 or 2

Procedure: Blood draw

Controls

The subject is considered a control and does not fall into any of the other cohorts

Procedure: Blood draw

Interventions

Blood draw PROCEDURE

One time intravenous blood draw

Affected Subjects; Controls; Family Members; Syndromes associated with Cardiovascular Disease

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Any individual with or without pediatric cardiovascular disease

You may qualify if:

• The subjects must have the diagnosis of cardiovascular disease
• The subject must have a syndrome associated with cardiovascular disease
• The subject must be related to an individual in cohort 1 or 2
• The subject is considered a control and does not fall into any of the other cohorts

You may not qualify if:

• N/A

Sponsors & Collaborators

• Mingtao Zhao: lead

Study Sites (1)

Nationwide Children's Hospital

Columbus, Ohio, 43205, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

6-12mL blood sample depending on age of patient

MeSH Terms

Conditions

Heart Defects, Congenital; Heart Diseases

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Cardiovascular Abnormalities; Cardiovascular Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Central Study Contacts

Jade F Hayden, BSN

CONTACT

16143555648; jade.hayden@nationwidechildrens.org

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Research Principal Investigator

Study Record Dates

• First Submitted: August 8, 2022
• First Posted: September 22, 2022
• Study Start: July 2, 2021
• Primary Completion (Estimated): December 31, 2030
• Study Completion (Estimated): December 31, 2030
• Last Updated: February 25, 2025

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)