NCT05549089

Brief Summary

CAD/CAM systems have assisted orthodontists in planning and positioning brackets to minimize errors and improve the excellence of treatment. This study aimed to validate measurements obtained from manual and digital systems, as well as evaluate the effectiveness, and periodontal changes that occurred after the treatment. Materials and Methods: This study is a prospective randomized controlled trial, in which clinical evaluation of virtual setup (digital and manual) techniques versus CAD/CAM brackets (Ormco© Insignia™ .022" twin brackets) in terms of expression of bracket prescription and treatment outcome. The sample consisted of 30 young adults with Angle Class I malocclusion. Cone beam computer tomography (CBCT) were obtained before and after the treatment to assess the parallelism between the dental roots and periodontal conditions. Digital impression by three dimensional (3D) intraoral scans (IOS) will be obtained for all participants. The 3D models are converted to stereolithography (STL) for all groups. The sample will be dividing randomly into three groups; the first one treated with CAD/CAM brackets (Ormco© Insignia™ .022" twin brackets), while the other two groups were treated by customization of bracket base of the conventional pre-adjusted twin bracket with orthodontic adhesive material, this will be done through planning and creating the virtual setup by using Maestro® 3D Ortho Studio software. The Indirect bonding devices for the second group will manufacturing from 3D printed models while third group from the manual double-layer vacuum-formed thermoplastic trays. All patients will treat with fixed orthodontic twin brackets appliances. The 3D models of the Virtual setup are comparing with the treated occlusion. The linear and angular measurements are performing by the Geomagic® software and using the 3Shape's Ortho-Analyzer TM software in all groups to assess the American Board of Orthodontics grading system scores. Random errors are assessing by Intra-class Correlation Coefficient (ICC) and method errors. Descriptive statistical analysis, Shapiro-Wilk test to detect the normality of variable distribution and the Chi-square test evaluated whether the ABO scores measurements are within the limits of agreement of each criterion. ABO scores between both groups are analyze by using Wilcoxon test. The Bland-Altman analysis evaluated if differences are within the limits of agreement.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jun 2022

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 3, 2022

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 30, 2022

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

September 12, 2022

Completed
1 day until next milestone

First Submitted

Initial submission to the registry

September 13, 2022

Completed
9 days until next milestone

First Posted

Study publicly available on registry

September 22, 2022

Completed
Last Updated

September 23, 2022

Status Verified

September 1, 2022

Enrollment Period

2 months

First QC Date

September 13, 2022

Last Update Submit

September 21, 2022

Conditions

Keywords

digital and manual orthodontic setupcustomized orthodontic bracketindirect bonding tray

Outcome Measures

Primary Outcomes (1)

  • American Board of Orthodontics (ABO) scoring

    scoring system consist of 8 items: 1\. Alignment, 2. Marginal ridge height, 3. Buccolingual inclination, 4. Overjet, 5. Occlusal contacts, 6. Occlusal relationships, 7. Interproximal contacts (1-7) Component: scores \< 0.5 = 0. 0.5 to 1 mm =1. \> 1 mm = 2. 8. Root angulation: Root parallelism = 0. Roots are not parallel = 1. Contacting adjacent tooth = 2. High scores on individual segments, or combinations of individual segments, may cause a case to become Incomplete. SO: the minimum value = 0 the maximum value = 16 the high score means = worse outcome the low score means = better outcome

    18 months

Secondary Outcomes (1)

  • linear and angular measurement of the bracket position

    4 months

Study Arms (3)

CAD/CAM Insignia™ brackets

EXPERIMENTAL

The result from this group (10 patients) considered as a gold standard for other two groups through assessing the treatment outcomes using American Board of Orthodontics (ABO) scoring.

Device: Insignia™ twin brackets

Software-driven indirect bonding tray

EXPERIMENTAL

The first comparison group (10 patients): digital setup, virtual bracket placement and creation of 3D printing indirect bounding tray by using Maestro® 3D Ortho Studio software.

Device: Maestro® 3D Ortho Studio software (Discovery, Dentaurum®, Ispringen, Germany)

Manual-driven indirect bonding tray

EXPERIMENTAL

the second comparison group (10 patients): digital setup by using Maestro® 3D Ortho Studio software, but the bracket positioning done manually by using Ray Set® device. in this group using double-layer vacuum-formed thermoplastic indirect bonding tray.

Device: Ray set® device (Discovery, Dentaurum®, Ispringen, Germany)

Interventions

it is metal orthodontic twin brackets with customized base and individual arch-wires for each patient

CAD/CAM Insignia™ brackets

it is conventional metal orthodontic twin brackets will be customizing the bracket base with adhesive composite, individual arch-wires for each patient and 3D printing indirect bonding tray

Software-driven indirect bonding tray

it is conventional metal orthodontic twin brackets will be customizing the bracket base with adhesive composite, individual arch-wires for each patient and double-layer vacuum-formed thermoplastic indirect bonding tray

Manual-driven indirect bonding tray

Eligibility Criteria

Age15 Years - 30 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Class 1 malocclusion.
  • Non-extraction treatment plan.
  • Initial Little Index between 5-10 mm.
  • Presence of all permanent teeth.

You may not qualify if:

  • Any systemic diseases such as diabetes, hypertension.
  • Sound or clicking in temporomandibular joint or craniofacial syndromes.
  • Periodontal disease or pockets greater than 4mm.
  • Incisor mandibular plane angle (IMPA) ≥ 100 degrees; or any anterior tooth completely blocked from the arch form

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

collage of dentistry-Baghdad university

Baghdad, 10001, Iraq

Location

Related Publications (1)

  • Al-Ubaydi AS, Al-Groosh D. Do the Various Indirect Bonding Techniques Provide the Same Accuracy for Orthodontic Bracket Placement? (Randomized Clinical Trial). Int J Dent. 2024 Jan 22;2024:5455197. doi: 10.1155/2024/5455197. eCollection 2024.

Study Officials

  • Dheaa H Al-Groosh, phd

    collage of dentistry- Baghdad university

    PRINCIPAL INVESTIGATOR
  • Ammar S Alubaydi, MSc

    collage of dentistry- Baghdad university

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
clinical and lab investigator (orthodontist, PhD student)

Study Record Dates

First Submitted

September 13, 2022

First Posted

September 22, 2022

Study Start

June 3, 2022

Primary Completion

July 30, 2022

Study Completion

September 12, 2022

Last Updated

September 23, 2022

Record last verified: 2022-09

Locations