COVID-19 Citizen Science Expansion Project

NCT05548803 | Completed

• 1 other identifier: 20203090
• Study Type: observational
• Target: 52,351
• Locations: 1 country
• Sites: 9

Brief Summary

COVID-19 Citizen Science (CCS), launched in March 2020, supports collaborative research on symptoms, risk factors, surveillance, biomarkers and testing for COVID-19 using the Eureka Research Platform. CCS maintains IRB approval with UCSF's IRB (UCSF IRB# 17-21879). This CCS Expansion Project, which is funded jointly by the National Institutes of Health (NIH), the Patient-Centered Outcomes Research Institute (PCORI), and the Bill and Melinda Gates Foundation, will invite patients at health systems across the US to contribute their health records data and then join the established CCS study, allows for linked analysis of CCS data and health records data, and provides the scientific rationale and plan for the project.

Conditions

Covid19

Outcome Measures

Primary Outcomes (1)

• GAD-7 anxiety score

  Anxiety is measured in monthly surveys using the seven-item General Anxiety Disorder-7 (GAD-7) questionnaire. Responses to each item in the GAD-7 are scored as integer values between 0-3 according to the frequency of symptoms during the preceding two weeks ("Not at all", "Several days", "More than half the days", or "Nearly every day"). The sum of all seven items produces a combined score between 0-21, where scores ≥ 10 are considered indicative of moderate to severe anxiety disorders

  Over the course of the pandemic, up to 5 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Our goal will be to recruit a large sample of participants that is representative of the US population. In particular, we wish to make inferences about Hispanic/LatinX and African- American/Black subsets of the US population, who appear to be especially vulnerable to both direct (infection-related) and indirect impact of the Pandemic.

You may qualify if:

• Age ≥ 18 years
• Has the capacity to read and comprehend English
• Has internet access and a device (computer, tablet, laptop, etc.) that can access it

You may not qualify if:

• \. Unable or unwilling to provide informed consent

Sponsors & Collaborators

• University of California, San Francisco: lead
• Sutter Health: collaborator
• Carelon Research: collaborator
• Louisiana Public Health Institute: collaborator
• Duke University: collaborator
• New York University: collaborator
• Albert Einstein College of Medicine: collaborator
• University of Utah: collaborator
• Ochsner Health System: collaborator
• Baylor Scott and White Health: collaborator
• Wake Forest University Health Sciences: collaborator
• New York City Health and Hospitals Corporation: collaborator

Study Sites (9)

Sutter Health

Sacramento, California, 95833, United States

Location

University of California, San Francisco

San Francisco, California, 94158, United States

Location

Advocate Aurora Health

Downers Grove, Illinois, 60515, United States

Location

Ochsner Health System

New Orleans, Louisiana, 70121, United States

Location

NYC Health + Hospitals

New York, New York, 10004, United States

Location

New York University

New York, New York, 10016, United States

Location

Albert Einstein College of Medicine

The Bronx, New York, 10467, United States

Location

Baylor Scott and White Health

Dallas, Texas, 95246, United States

Location

University of Utah

Salt Lake City, Utah, 84132, United States

Location

Related Publications (3)

• Cozen AE, Hamad R, Park S, Marcus GM, Olgin JE, Faulkner Modrow M, Chiang A, Brandner M, Orozco JH, Azar K, Sudat SEK, Isasi CR, Williams N, Ozluk P, Kitzman H, Knight SJ, Sanchez-Birkhead A, Kornak J, Carton T, Pletcher M. Associations between local COVID-19 policies and anxiety in the USA: a longitudinal digital cohort study. BMJ Public Health. 2025 Jan 16;3(1):e001135. doi: 10.1136/bmjph-2024-001135. eCollection 2025.

  PMID: 40017931 BACKGROUND

• Cozen AE, Carton T, Hamad R, Kornak J, Faulkner Modrow M, Peyser ND, Park S, Orozco JH, Brandner M, O'Brien EC, Djibo DA, McMahill-Walraven CN, Isasi CR, Beatty AL, Olgin JE, Marcus GM, Pletcher MJ. Factors associated with anxiety during the first two years of the COVID-19 pandemic in the United States: An analysis of the COVID-19 Citizen Science study. PLoS One. 2024 Feb 6;19(2):e0297922. doi: 10.1371/journal.pone.0297922. eCollection 2024.

  PMID: 38319951 RESULT

• Crull E, O'Brien EC, Antiperovitch P, Asfaw K, Beatty AL, Djibo DA, Kaul AF, Kornak J, Marcus GM, Modrow MF, Olgin JE, Orozco J, Park S, Peyser N, Pletcher MJ, Carton TW. Concordance Between Survey and Electronic Health Record Data in the COVID-19 Citizen Science Study: Retrospective Cohort Analysis. JMIR Form Res. 2025 Jul 28;9:e58097. doi: 10.2196/58097.

  PMID: 40720880 DERIVED

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Mark Pletcher, MD, MPH

  University of California, San Francisco

  PRINCIPAL INVESTIGATOR

• Thomas Carton, PhD

  Louisiana Public Health Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 19, 2022
• First Posted: September 21, 2022
• Study Start: March 18, 2020
• Primary Completion: September 1, 2024
• Study Completion: September 1, 2024
• Last Updated: July 8, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (9)