Aetiology of Asymmetrical Hearing Loss: A Retro-spective Study Thesis Submitted for Partial Fulfillment of Master Degree in Audio-Vestibular Medicine

NCT05543135 | Unknown

• 1 other identifier: Soh-Med-22-07-09
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Hearing loss maybe: -Symmetrical: in which the severity and pattern of hearing loss are the same in each ear. Or -Asymmetrical: is defined as binaural difference in bone conduction thresholds of \>10 dB at two consecutive frequencies or \>20 dB at one frequency (0.25-8.0 kHz), Poorer speech perception will often accompany poorer hearing and may be the reason for the patient's presentation .Unilateral or asymmetrical sensorineural hearing loss is important to discern, as it is an important risk factor for auditory nerve tumors (i.e. vestibular schwannoma) which is a life threatening condition, and in such cases further investigation is required (i.e. MRI scan) unless there is a known reason for the asymmetry, Several reports have recommended that further evaluation, especially expensive imaging studies, be conducted to rule out acoustic tumors when AHL is present

Conditions

Asymmetrical Hearing Loss

Outcome Measures

Primary Outcomes (1)

• Asymmetrical hearing loss

  asymmetrical hearing loss using basic audiological evalution \&imaging

  1 year

Study Arms (1)

cases

patients with asymmetrical hearing loss

Diagnostic Test: basic audiological evaluation

Interventions

basic audiological evaluation DIAGNOSTIC_TEST

pure tone audiometry\&immitancemetry

Also known as: CT&MRI

cases

Eligibility Criteria

• Age: 6 Years+
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

all patients with asymmetrical hearing loss with age ranging 6 years old and more.

You may qualify if:

• Age: 6 years old and more.
• Sex: male and female.

You may not qualify if:

• Age: less than 6 years old.
• Patients with symmetrical hearing loss.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University Hospital

Sohag, Egypt

Location

Related Publications (4)

• Dunn CC, Tyler RS, Oakley S, Gantz BJ, Noble W. Comparison of speech recognition and localization performance in bilateral and unilateral cochlear implant users matched on duration of deafness and age at implantation. Ear Hear. 2008 Jun;29(3):352-9. doi: 10.1097/AUD.0b013e318167b870.

  PMID: 18453885 BACKGROUND

• Margolis RH, Saly GL. Asymmetric hearing loss: definition, validation, and prevalence. Otol Neurotol. 2008 Jun;29(4):422-31. doi: 10.1097/MAO.0b013e31816c7c09.

  PMID: 18418281 BACKGROUND

• Peng AW, Salles FT, Pan B, Ricci AJ. Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction. Nat Commun. 2011 Nov 1;2:523. doi: 10.1038/ncomms1533.

  PMID: 22045002 BACKGROUND

• Plack CJ, Barker D, Hall DA. Pitch coding and pitch processing in the human brain. Hear Res. 2014 Jan;307:53-64. doi: 10.1016/j.heares.2013.07.020. Epub 2013 Aug 11.

  PMID: 23938209 BACKGROUND

Central Study Contacts

Enas M Mahrous, resident doctor

CONTACT

01096769904; inas_mahmoud_post@med.sohag.edu.eg

Mohamed A Abdelrahman, professor

CONTACT

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor at audiovestibular unit Qena general hospital

Study Record Dates

• First Submitted: September 14, 2022
• First Posted: September 16, 2022
• Study Start: September 20, 2022
• Primary Completion: September 1, 2023
• Study Completion: September 1, 2023
• Last Updated: September 16, 2022

Record last verified: 2022-09

Locations

EG (1)