Study of Thyroid Status in Patients With IBD

NCT05542368 | Unknown

• 1 other identifier: thyroid state in IBD patients
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

. The aim of the present study is to study thyroid state in patients with IBD

Conditions

Thyroid Disease; Irritable Bowel Disease

Outcome Measures

Primary Outcomes (1)

• Percentage of thyroid disorders in patients with IBD

  By use of Thyroid function test (include T3-T4- TSH), thyroid antibodies and thyroid sonography

  1 year

Study Arms (2)

Patients with IBD

All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction. b) Laboratory investigations: Thyroid function test (include T3-T4- TSH) * ESR - CRP - thyroid antibodies: (Anti TPO -Anti Thyroglobulin) c)-Imaging: * Neck U/S on thyroid gland to identify patients with ultrasonographic evidence of autoimmune thyroiditis (diffuse hypoechogenicity or heterogenicity echotexture or both) and to detect thyroid nodularity. d ) Endoscopic findings regarding diagnosis of IBD confirmed by histopathological examination

Diagnostic Test: Thyroid tests

Healty individuals as a control group

All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction. b) Laboratory investigations: Thyroid function test (include T3-T4- TSH) * ESR - CRP - thyroid antibodies: (Anti TPO -Anti Thyroglobulin) c)-Imaging: * Neck U/S on thyroid gland to identify patients with ultrasonographic evidence of autoimmune thyroiditis (diffuse hypoechogenicity or heterogenicity echotexture or both) and to detect thyroid nodularity.

Diagnostic Test: Thyroid tests

Interventions

Thyroid tests DIAGNOSTIC_TEST

Thyroid function test TSH ,T3,T4 Thyroid antibody test anti TPO,antithyroglobulin

Also known as: Thyroid function test and thyroid antibodies

Healty individuals as a control group; Patients with IBD

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients with IBD admitted at Assiut University Hospital, Al Rajhi Liver Hospital or attending IBD outpatient clinic. a. Inclusion criteria: All patients with IBD Exclusion criteria: patients with * Thyroid disease * Acute or chronic kidney * Acute or Chronic Liver Disease. Active Lupus - * Malignancy * patients taking medications that affect thyroid function as rifampin, amiodarone

You may not qualify if:

• patients with
• Thyroid disease
• Acute or chronic kidney
• Acute or Chronic Liver Disease. Active Lupus -
• Malignancy
• patients taking medications that affect thyroid function as rifampin, amiodarone …..

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University

Asyut, Egypt

Location

Related Links

• nflammatory bowel disease severity and activity are correlated to thyroid gland nodularity, chronic nonthyroidal illness, and thyroid autoantibodies but not thyroid dysfunction
• Role of autoantibodies in the pathogenesis and association of endocrine autoimmune disorders
• Autoimmune thyroid disease (Graves' disease and hashimoto's thyroiditis) in two patients with Crohn's disease: case reports and literature review
• Simultaneous occurrence of inflammatory bowel disease and thyroid disease
• Coexistence of Addison's disease, ulcerative colitis, hypothyroidism and pernicious anemia

MeSH Terms

Conditions

Thyroid Diseases; Irritable Bowel Syndrome

Interventions

Thyroid Function Tests

Condition Hierarchy (Ancestors)

Endocrine System Diseases; Colonic Diseases, Functional; Colonic Diseases; Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Endocrine; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Abo zaid Ali, assistant prof

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Hassan, Resident

CONTACT

+201144971296; nisreenhassan6@gmail.com

Abu Bakr Elisily, professor

CONTACT

+201006564000; fatmaelosily@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 20, 2022
• First Posted: September 15, 2022
• Study Start: December 1, 2022
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: September 15, 2022

Record last verified: 2022-09

Locations

EG (1)