Impact Of Thyroid Dysfunction on Liver Function Tests

NCT07354048 | Recruiting

• 1 other identifier: Soh-Med--25-7-9MS
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the effect of thyroid dysfunction on liver function tests.

Conditions

Thyroid Disease

Outcome Measures

Primary Outcomes (1)

• Measuring total bilirubin level in patients with thyroid dysfunction diseases

  Collecting blood samples from the patients

  1 months

Study Arms (4)

Control group

Other: Control group

Patients with hypothyroidism or hyperthyroidism that are controlled on treatment

Other: Patients with hypothyroidism or hyperthyroidism that are controlled on treatment

Patients with hypothyroidism or hyperthyroidism that are not controlled on treatment

Other: Patients with hypothyroidism or hyperthyroidism that are not controlled on treatment

Patients with hypothyroidism or hyperthyroidism that are firstly discovered

Other: Patients with hypothyroidism or hyperthyroidism that are firstly discovered

Interventions

Patients with hypothyroidism or hyperthyroidism that are not controlled on treatment OTHER

This group includes patients with hypothyroidism or hyperthyroidism that are not controlled on treatment

Patients with hypothyroidism or hyperthyroidism that are not controlled on treatment

Patients with hypothyroidism or hyperthyroidism that are firstly discovered OTHER

This group includes patients with hypothyroidism or hyperthyroidism that are firstly discovered

Patients with hypothyroidism or hyperthyroidism that are firstly discovered

Control group OTHER

Healthy people

Control group

Patients with hypothyroidism or hyperthyroidism that are controlled on treatment OTHER

This group includes patients with hypothyroidism or hyperthyroidism that are controlled on treatment

Patients with hypothyroidism or hyperthyroidism that are controlled on treatment

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

All patients between the ages of 20-60 years old either with Hypothyroidism or Hyperthyroidism (controlled on treatment or not) and firstly diagnosed Hypothyroidism or Hyperthyroidism.

You may qualify if:

• All patients between the ages of 20-60 years old either with Hypothyroidism or Hyperthyroidism (controlled on treatment or not) and firstly diagnosed Hypothyroidism or Hyperthyroidism.
• Euthyroid controls (clinically healthy control subjects were recruited from the general population with the same socio-economic status with the subjects.)

You may not qualify if:

• Patients aged \< 20 years old.
• Patients With Liver Disease.
• Pregnant and lactating women.
• Patients with severe infections or sepsis.
• Patients with Heart Disease.
• Patients who on drugs that can affect liver function such as phenothiazine, phenylbutazone, methyldopa, among others.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University Hospital

Sohag, Egypt

RECRUITING

Related Publications (3)

• Boelaert K, Franklyn JA. Thyroid hormone in health and disease. J Endocrinol. 2005 Oct;187(1):1-15. doi: 10.1677/joe.1.06131.

  PMID: 16214936 BACKGROUND

• Malik R, Hodgson H. The relationship between the thyroid gland and the liver. QJM. 2002 Sep;95(9):559-69. doi: 10.1093/qjmed/95.9.559.

  PMID: 12205333 BACKGROUND

• Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev. 2002 Feb;23(1):38-89. doi: 10.1210/edrv.23.1.0455.

  PMID: 11844744 BACKGROUND

MeSH Terms

Conditions

Thyroid Diseases

Interventions

Control Groups

Condition Hierarchy (Ancestors)

Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Central Study Contacts

Omnia A Mohamed, Resident

CONTACT

01285252564; omnia_ahmed_post@med.sohag.edu.eg

Usama M Abdel-Aal, Professor

CONTACT

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident, Internal Medicine Department, Faculty of Medicine, Sohag University

Study Record Dates

• First Submitted: September 30, 2025
• First Posted: January 21, 2026
• Study Start: July 14, 2025
• Primary Completion: January 30, 2026
• Study Completion: January 30, 2026
• Last Updated: January 21, 2026

Record last verified: 2026-01

Locations

EG (1)