NCT05540119

Brief Summary

The overarching aim of this nationwide Swedish cohort study is to reduce death and suffering from oesophageal and gastric tumours. This aim can be accomplished by a broad research approach that aims to identify:

  1. 1.Risk factors and preventive actions
  2. 2.Early detection
  3. 3.Improved treatment

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
25,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started May 2017

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2017

Completed
3.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2020

Completed
2 years until next milestone

First Submitted

Initial submission to the registry

September 9, 2022

Completed
5 days until next milestone

First Posted

Study publicly available on registry

September 14, 2022

Completed
12 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2023

Completed
Last Updated

September 19, 2022

Status Verified

September 1, 2022

Enrollment Period

3.3 years

First QC Date

September 9, 2022

Last Update Submit

September 15, 2022

Conditions

Oesophageal CancerGastric CancerSurgical TreatmentAetiologyPrognostic FactorsSurvivalPredictionTreatment

Outcome Measures

Primary Outcomes (1)

  • Mortality

    5-year all-cause and disease-specific mortality

    5 years

Secondary Outcomes (1)

  • Complications

    Within 30 days of surgery

Study Arms (2)

SWEGASS

Gastric cancer patients.

Procedure: Surgery

SESS

Oesophageal cancer patients.

Procedure: Surgery

Interventions

SurgeryPROCEDURE

Patients who undergo surgery are separately assessed

SESSSWEGASS

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All patients with oesophageal or gastric cancer in Sweden from year 2006 onwards are included in the source cohort, but only those who undergo surgery are included in this project.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Karolinska Institutet

Stockholm, 17177, Sweden

RECRUITING

Related Publications (1)

  • Xie SH, Santoni G, Bottai M, Gottlieb-Vedi E, Lagergren P, Lagergren J. Prediction of conditional survival in esophageal cancer in a population-based cohort study. Int J Surg. 2023 May 1;109(5):1141-1148. doi: 10.1097/JS9.0000000000000347.

    PMID: 36999825DERIVED

MeSH Terms

Conditions

Esophageal NeoplasmsStomach Neoplasms

Interventions

Surgical Procedures, Operative

Condition Hierarchy (Ancestors)

Gastrointestinal NeoplasmsDigestive System NeoplasmsNeoplasms by SiteNeoplasmsHead and Neck NeoplasmsDigestive System DiseasesEsophageal DiseasesGastrointestinal DiseasesStomach Diseases

Study Officials

  • Jesper Lagergren, MD PhD

    Karolinska Institutet

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Jesper Lagergren, MD PhD

CONTACT

0046852485140jesper.lagergren@ki.se

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor of Surgery

Study Record Dates

First Submitted

September 9, 2022

First Posted

September 14, 2022

Study Start

May 1, 2017

Primary Completion

September 1, 2020

Study Completion

August 31, 2023

Last Updated

September 19, 2022

Record last verified: 2022-09

Locations

SE(1)