Evaluation of Indirect Measurement of Respiratory Quotient in Non-cardiac Major Surgery (The BAR Study)

NCT03471962 | Completed

• 1 other identifier: PI2017_843_0006
• Study Type: observational
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

Demonstrate the ability of the RQ, measured indirectly from the anesthesia ventilator, to predict the occurrence of anaerobic metabolism in patients operated of major non-cardiac surgical operation in the operating room

Conditions

Surgery

Keywords

respiratory quotient (RQ); anaerobic metabolism; major surgery

Outcome Measures

Primary Outcomes (1)

• Respiratory Quotient (RQ)

  indirectly measured from the anesthetic respirator, and its predictive ability to develop anaerobic metabolism.

  1 Month

Interventions

surgery OTHER

Indirect measurement of RQ was performed by anesthesia ventilator and compared to marker of anaerobic metabolism (arterial lactate, venoarterial PCO2 gradient, venoarterial PCO2 gradient/ arteriovenous O2 content difference, ScVO2) at different time of the srugery (every hours). In post-operative time, complications and hospital's length of stay were recorded.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients admitted to the operating room of Amiens University Hospital supported for major non-cardiac surgery (abdominal, orthopedic, vascular) for which the practitioner had decided in accordance with the care protocols of the department to carry out an hemodynamic optimization

You may qualify if:

• Adult patients admitted to the operating room of Amiens University Hospital supported for major non-cardiac surgery (abdominal, orthopedic, vascular) for which the practitioner had decided in accordance with the care protocols of the department to carry out an hemodynamic optimization,
• Patients monitored by a central venous catheter and an invasive measurement of blood pressure,
• Ventilated patients in controlled mode,
• Major patients.

You may not qualify if:

• Cardiac surgery with the need of extracorporeal circulation
• Thoracic surgery with the need of unipulmonary ventilation
• Permanent laparoscopic surgery and up to 30 minutes after exsufflation of CO2
• Acute or chronic respiratory insufficiency documented
• Interstitial lung disease with diffusion disorders
• Preoperative oxygen therapy
• Acute Respiratory Distress Syndrome with FiO2\> 60%.
• Refusal of patient participation.
• Pregnant woman.
• Patient under guardianship or curatorship or deprived of public right.

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens-Picardie

Amiens, 80054, France

Location

Related Publications (1)

• Bar S, Grenez C, Nguyen M, de Broca B, Bernard E, Abou-Arab O, Bouhemad B, Lorne E, Guinot PG. Predicting postoperative complications with the respiratory exchange ratio after high-risk noncardiac surgery: A prospective cohort study. Eur J Anaesthesiol. 2020 Nov;37(11):1050-1057. doi: 10.1097/EJA.0000000000001111.

  PMID: 31688330 DERIVED

MeSH Terms

Interventions

Surgical Procedures, Operative

Study Officials

• Stéphane BAR, Dr

  CHU AMIENS-PICARDIE

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 14, 2018
• First Posted: March 21, 2018
• Study Start: May 4, 2017
• Primary Completion: August 30, 2018
• Study Completion: August 30, 2018
• Last Updated: September 18, 2018

Record last verified: 2018-08

Locations

FR (1)