Diagnosis of Transient Tachypnea of Newborn

NCT05538780 | Unknown

• 1 other identifier: 34987/10/21
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Transient tachypnea of the newborn (TTN) is the most common cause of respiratory distress in fullterm newborn. TTN is a diagnosis of exclusion, It is primarily diagnosed based on medical history and typical clinical presentation. Lung ultrasonography is an accurate, non invasive and reliable tool for diagnosing TTN. Cardiometry is presently the only tool to evaluate thoracic fluid content continuously and noninvasively at the bedside.

Conditions

Transient Tachypnea of the Newborn

Outcome Measures

Primary Outcomes (2)

• change of thoracic fluid content

  measured by electrical cardiometry ( ICON®; Osypka Medical, Berlin, Germany)

  at enrollment and after 72 hours of birth

• change of ultrasound data: double-lung point, interstitial lung syndrome, and fuzziness of the pleural lines (A-lines) and pleural effusion.

  using Siemens Acuson X300 ultrasound machine ( Siemens Health Care GmbH, Erlangen, Germany )

  at enrollment and after 72 hours of birth

Eligibility Criteria

• Age: 0 Days - 3 Days
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

50 neonates diagnosed with Transient Tachypnea of Newborn admitted at Neonatal Intensive Care Unit, Tanta University Hospitals

You may qualify if:

• fifty newborns with gestational age ≥ 34 weeks (calculated from the first day of last menstrual period and using New Ballard score) diagnosed with TTN

You may not qualify if:

• Gestational age less than 34 weeks.
• Major congenital abnormalities.
• Congenital heart diseases.
• Neonatal sepsis.
• Neonatal pneumonia.
• Other causes of respiratory distress (RD)

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University, faculty of medicine

Tanta, 31527, Egypt

RECRUITING

Related Publications (3)

• Hammad Y, Hasanin A, Elsakka A, Refaie A, Abdelfattah D, Rahman SA, Zayed M, Hassabelnaby Y, Mukhtar A, Omran A. Thoracic fluid content: a novel parameter for detection of pulmonary edema in parturients with preeclampsia. J Clin Monit Comput. 2019 Jun;33(3):413-418. doi: 10.1007/s10877-018-0176-6. Epub 2018 Jun 23.

  PMID: 29936563 BACKGROUND

• Paviotti G, De Cunto A, Moressa V, Bettiol C, Demarini S. Thoracic fluid content by electric bioimpedance correlates with respiratory distress in newborns. J Perinatol. 2017 Sep;37(9):1024-1027. doi: 10.1038/jp.2017.100. Epub 2017 Jul 27.

  PMID: 28749485 BACKGROUND

• Ibrahim M, Omran A, AbdAllah NB, Ibrahim M, El-Sharkawy S. Lung ultrasound in early diagnosis of neonatal transient tachypnea and its differentiation from other causes of neonatal respiratory distress. J Neonatal Perinatal Med. 2018;11(3):281-287. doi: 10.3233/NPM-181796.

  PMID: 30040751 BACKGROUND

MeSH Terms

Conditions

Transient Tachypnea of the Newborn

Condition Hierarchy (Ancestors)

Respiratory Distress Syndrome, Newborn; Respiratory Distress Syndrome; Lung Diseases; Respiratory Tract Diseases; Respiration Disorders; Tachypnea; Infant, Premature, Diseases; Infant, Newborn, Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• ashraf abuhamama

  Tanta university faculty of medicine

  STUDY DIRECTOR

Central Study Contacts

ashraf abuhamama, PhD

CONTACT

0020403322645; ashraf.abohamama@med.tanta.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: clinical professor

Study Record Dates

• First Submitted: September 9, 2022
• First Posted: September 14, 2022
• Study Start: January 1, 2022
• Primary Completion: November 1, 2022
• Study Completion: January 1, 2023
• Last Updated: September 16, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)