Effect of Resistance Training on Energy Intake and Appetite Regulation, 12-weeks Resistance Training

NCT05530629 | Unknown DMC

• 1 other identifier: Wang Qiang
• Study Type: interventional
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

Resistance training is a common way of daily exercise which has a remarkable function in healthcare. It has been used in many diseases as a complementary method. Overweight and obesity are the sixth highest risk of death worldwide. In recent years, the data show that the rate of overweight obese among college students shows a significant increasing trend. The common characteristics of overweight and obese people are strong appetite which is difficult to be controled and sedentary. resistance training is a solid supplement to physical education and how to reduce appetite of overweight and obese college female students through resistance training is the key to increase their health by university sport course. The training plan divides the training intensity into three levels including 45-50% one repetition maximum(1RM), 60-65% 1RM, 45-50% 1RM, respectively plus control group. Therefore, this experimental research examines the effectiveness and the differences of three Intensities resistance training on energy intake and appetite regulation among overweight and obese college girl. Finally, to evaluate whether the resistance training can reduce the overweight and obese female college students' energy intake and appetite regulation

Conditions

Overweight; Obese

Keywords

Resistance training; Energy intake; Appetite; College Girl

Outcome Measures

Primary Outcomes (16)

• Change from baseline BMI at 6 weeks and 12 weeks.

  This parameter belongs to Obesity Degree.

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline body fat percentage at 6 weeks and 12 weeks.

  This parameter belongs to Obesity Degree.

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline waist circumference at 6 weeks and 12 weeks.

  This parameter belongs to Obesity Degree.

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline energy intake at 6 weeks and 12 weeks.

  This parameter will be recorded by Quantitative Daily Dietary Intake (QDI): three multiple-pass 24-hr recalls collected at each assessment time point by a research dietitian/technician. Analysis by Food Processor Nutrition Analysis Software (Version 9.6, 2005, ESHA Research, Salem, OR): recalls are analysed for calorie and macronutrient content

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline hunger at 6 weeks and 12 weeks.

  This parameter will be test by 100-mm visual analogue scale (VAS): test at 6:00-8:00 am following a 10h overnight fast, rate perceive appetite firstly. Then provide with a standardised caloric stimulus, at 30, 60, 90 and 120min post consumption rate perceived appetite again (r = 0.42 - 0.85). At every time point, both lengths of VAS 100 mm were used to record desire to eat, hunger, fullness, and prospective food consumption. The four standardized questions were: (i) how strong is your desire to eat? ("very weak" to "very strong"), (ii) how hungry do you feel? ("not hungry at all" to "as hungry as I've ever felt"), (iii) how full do you feel? ("not full at all" to "very full"), and (iv) how much food do you think you can eat? (Prospective food consumption; "nothing at all" to "a large amount") .

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline fullness at 6 weeks and 12 weeks.

  This parameter will be test by 100-mm visual analogue scale (VAS): test at 6:00-8:00 am following a 10h overnight fast, rate perceive appetite firstly. Then provide with a standardised caloric stimulus, at 30, 60, 90 and 120min post consumption rate perceived appetite again (r = 0.42 - 0.85). At every time point, both lengths of VAS 100 mm were used to record desire to eat, hunger, fullness, and prospective food consumption. The four standardized questions were: (i) how strong is your desire to eat? ("very weak" to "very strong"), (ii) how hungry do you feel? ("not hungry at all" to "as hungry as I've ever felt"), (iii) how full do you feel? ("not full at all" to "very full"), and (iv) how much food do you think you can eat? (Prospective food consumption; "nothing at all" to "a large amount") .

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline desire to eat at 6 weeks and 12 weeks.

  This parameter will be test by 100-mm visual analogue scale (VAS): test at 6:00-8:00 am following a 10h overnight fast, rate perceive appetite firstly. Then provide with a standardised caloric stimulus, at 30, 60, 90 and 120min post consumption rate perceived appetite again (r = 0.42 - 0.85). At every time point, both lengths of VAS 100 mm were used to record desire to eat, hunger, fullness, and prospective food consumption. The four standardized questions were: (i) how strong is your desire to eat? ("very weak" to "very strong"), (ii) how hungry do you feel? ("not hungry at all" to "as hungry as I've ever felt"), (iii) how full do you feel? ("not full at all" to "very full"), and (iv) how much food do you think you can eat? (Prospective food consumption; "nothing at all" to "a large amount") .

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline prospective food consumption at 6 weeks and 12 weeks.

  This parameter will be test by 100-mm visual analogue scale (VAS): test at 6:00-8:00 am following a 10h overnight fast, rate perceive appetite firstly. Then provide with a standardised caloric stimulus, at 30, 60, 90 and 120min post consumption rate perceived appetite again (r = 0.42 - 0.85). At every time point, both lengths of VAS 100 mm were used to record desire to eat, hunger, fullness, and prospective food consumption. The four standardized questions were: (i) how strong is your desire to eat? ("very weak" to "very strong"), (ii) how hungry do you feel? ("not hungry at all" to "as hungry as I've ever felt"), (iii) how full do you feel? ("not full at all" to "very full"), and (iv) how much food do you think you can eat? (Prospective food consumption; "nothing at all" to "a large amount") .

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline glucose at 6 weeks and 12 weeks.

  Blood is collected into Vacutainers (BectonDickinson, Franklin Lakes, NJ) containing SST Gel (Becton Dickinson), Ethylenediaminetetraacetic acid(EDTA), or heparin and is immediately placed on ice and centrifuged (4 C, 1500g, 15 min). The serum or plasma obtained is stored in multiple aliquots at 75 C until assayed (in duplicate). Glucose is determined by the glucose oxidase method (Sigma-Aldrich Corp; 3.8% and 4.9% inter- and intraassay coefficients of variation) (70～140mg/dl or 3.9～7.8mmol/l)

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline leptin at 6 weeks and 12 weeks.

  Blood is collected into Vacutainers (BectonDickinson, Franklin Lakes, NJ) containing Serum-separating tube(SST) Gel (Becton Dickinson), EDTA, or heparin and is immediately placed on ice and centrifuged (4 C, 1500g, 15 min). The serum or plasma obtained is stored in multiple aliquots at 75 C until assayed (in duplicate). Serum leptin is determined by an ELISA with a commercially available kit (EIA-2395, DRG, Marburg, Germany; 5.9% intraassay precision; 6.8% interassay accuracy; sensitivity of 0.5ng/ml).

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline adiponectin at 6 weeks and 12 weeks.

  Blood is collected into Vacutainers (BectonDickinson, Franklin Lakes, NJ) containing SST Gel (Becton Dickinson), EDTA, or heparin and is immediately placed on ice and centrifuged (4 C, 1500g, 15 min). The serum or plasma obtained is stored in multiple aliquots at 75 C until assayed (in duplicate). Plasma adiponectin is analysed with a commercially available radioimmunoassay (RIA) (Linco Research, Inc., St. Charles, mo; 6.9% intraassay precision; 7.8% interassay accuracy; sensitivity of 0.5ng/ml.) (3\~30μg/mL).

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline NPY at 6 weeks and 12 weeks.

  Blood is collected into Vacutainers (BectonDickinson, Franklin Lakes, NJ) containing SST Gel (Becton Dickinson), EDTA, or heparin and is immediately placed on ice and centrifuged (4 C, 1500g, 15 min). The serum or plasma obtained is stored in multiple aliquots at 75 C until assayed (in duplicate). Neuropeptide Y is measured by Liquid Chromatography with tandem mass spectrometry (LC-MS/MS) (NPY; Phoenix Europe Gesellschaft mit beschränkter Haftung (GmbH), Karlsruhe, Germany; Sensitivity of 0.13 ng/ml; Intra-assay variability \<5%) (51.23～209.65 pg/ml).

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline Insulin at 6 weeks and 12 weeks.

  Blood is collected into Vacutainers (BectonDickinson, Franklin Lakes, NJ) containing SST Gel (Becton Dickinson), EDTA, or heparin and is immediately placed on ice and centrifuged (4 C, 1500g, 15 min). The serum or plasma obtained is stored in multiple aliquots at 75 C until assayed (in duplicate). Insulin is measured with an immunoassay (Access Immunoassay System, Beckman Coulter, Fullerton, California (CA); 4.9% intraassay precision; 3.8% interassay accuracy; sensitivity of 0.5 μu/ml) (60-100mg/dl).

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline meal-time at 6 weeks and 12 weeks.

  This parameter record by Quantitative Daily Dietary Intake (QDI): three multiple-pass 24-hr recalls collected at each assessment time point by a research dietitian/technician. Analysis by Food Processor Nutrition Analysis Software (Version 9.6, 2005, ESHA Research, Salem, OR): recalls are analysed for the percentage of day and night total kcals intake separately.

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline stress of eating at 6 weeks and 12 weeks.

  This parameter measured by The Salzburg Stress Eating Scale (SSES) which is the first to specifically address the relationship of stress experiences and coping failure on the one hand and increases or decreases in food intake on the other hand. Higher SSES scores indicate eating more when stressed, while lower scores indicate eating less when stressed.

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

• Change from baseline physical activity level at 6 weeks and 12 weeks.

  This parameter measured by Global Physical Activity Questionnaire (GPAQ). The GPAQ covers several components of physical activity, such as intensity, duration, and frequency, and it assesses three domains in which physical activity is performed (occupational physical activity, transport-related physical activity, and physical activity during discretionary or leisure time) comprising 16 questions (P1-P16). Since it was developed by World Health Organization (WHO) in 2002, the GPAQ has undergone a research program which shows that it is valid and reliable. It has become the most common tool in diagnostic and evaluation studies of physical activity globally.

  Pretest: Before experiment; Mid-test: 6 weeks end; Post-test: 12 weeks end.

Study Arms (4)

High intensity of resistance training

EXPERIMENTAL

The intensity of 75-80% 1RM is used for high intensity resistance training group. The number of repetitions of each set is relatively few, only 6-8 times. The rest time between sets is relatively long, 2-3 minutes, so that the participants can better adapt to this intensity. chest press, lat pull down, shoulder press and square, which are all trained through the multi-functional Smith machine. Bicep curl and triceps extension are operated by purchasing dumbbells with different weights. Leg extension and Leg curl use leg extension and curl machine Abdominal crunches and lower back exercises just do it by body weight training in yoga mat with abdominal curl and Lower back bridge

Device: resistance training

Moderate intensity of resistance training

EXPERIMENTAL

The intensity of 60-65% 1RM is used for moderate intensity resistance training group. The repetition times of each set are relatively moderate, 10-12 times. The rest time between sets is relatively moderate, 1-2 minutes. The relative exercise volume of this group was consistent with that of other experimental groups chest press, lat pull down, shoulder press and square, which are all trained through the multi-functional Smith machine. Bicep curl and triceps extension are operated by purchasing dumbbells with different weights. Leg extension and Leg curl use leg extension and curl machine Abdominal crunches and lower back exercises just do it by body weight training in yoga mat with abdominal curl and Lower back bridge

Device: resistance training

Low intensity of resistance training

EXPERIMENTAL

The intensity of 40-45% 1RM is used for low intensity resistance training group. The repetition times of each set are relatively more, 16-18 times. The rest time between groups is short, only about 1 minute, so that the participants can still maintain sufficient total exercise load under low intensity. chest press, lat pull down, shoulder press and square, which are all trained through the multi-functional Smith machine. Bicep curl and triceps extension are operated by purchasing dumbbells with different weights. Leg extension and Leg curl use leg extension and curl machine Abdominal crunches and lower back exercises just do it by body weight training in yoga mat with abdominal curl and Lower back bridge

Device: resistance training

Normal P.E. course

OTHER

Carry out general teaching content according to the college syllabus.

Device: Normal P.E. course

Interventions

resistance training DEVICE

resistance training lasts for 12 weeks, three times a week, one hour each time, and the program of resistance training in the experimental group was divided into 10 exercises: Chest press, Lat pull down, Shoulder press, Squat, Leg extension, Leg curl, Bicep curl, Triceps extension, abdominal crunches, lower back exercises.

High intensity of resistance training; Low intensity of resistance training; Moderate intensity of resistance training

Normal P.E. course DEVICE

Carry out general teaching content according to the college syllabus lasts for 12 weeks , three times a week, one hour each time, and the program of Normal P.E. course in the control group will be Physical recovery exercises, learn and practice queue formation, calisthenics, five step fists, long fist and Basic movements of Gymnastics gradually changed by week.

Normal P.E. course

Eligibility Criteria

• Age: 18 Years - 22 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Overweight or obese (BMI\> 25)
• Female
• College students
• Healthy

You may not qualify if:

• The subjects lack regular and active exercise program in last three months
• The subjects are not on a diet in last three months. c, Do not have regular menstrual cycle or approaching the normal menstrual cycle

Sponsors & Collaborators

• Universiti Putra Malaysia: lead

Study Sites (1)

YiChun Education College

Yichun, Jiangxi, 336000, China

Location

Related Publications (2)

• Bales CW, Hawk VH, Granville EO, Rose SB, Shields T, Bateman L, Willis L, Piner LW, Slentz CA, Houmard JA, Gallup D, Samsa GP, Kraus WE. Aerobic and resistance training effects on energy intake: the STRRIDE-AT/RT study. Med Sci Sports Exerc. 2012 Oct;44(10):2033-9. doi: 10.1249/MSS.0b013e318259479a.

  PMID: 22525775 RESULT

• Wang Q, Xiao WS, Danaee M, Geok SK, Gan WY, Zhu WL, Mai YQ. Impact of resistance training intensity on body composition and nutritional intake among college women with overweight and obesity: a cluster randomized controlled trial. Front Public Health. 2025 May 30;13:1589036. doi: 10.3389/fpubh.2025.1589036. eCollection 2025.

  PMID: 40520279 DERIVED

Related Links

• Description This article is from National Library of Medinice

MeSH Terms

Conditions

Overweight; Obesity

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Qiang Wang, Doctor

  University Putra Malaysia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Model Details: In this experiment, the three experimental groups will conduct different intensities resistance training, and the control group take the normal P.E. course.

Study Record Dates

• First Submitted: August 28, 2022
• First Posted: September 7, 2022
• Study Start: August 20, 2022
• Primary Completion: October 15, 2022
• Study Completion: December 1, 2023
• Last Updated: September 7, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)