Respiratory Complications of Operated Esophageal Atresia in Children

NCT05527873 | Completed

• 1 other identifier: 8562
• Study Type: observational
• Target: 67
• Locations: 1 country
• Sites: 1

Brief Summary

The respiratory complications of esophageal atresia have already been identified. They are mainly related to tracheomalacia linked to the esophageal malformation, and are aggravated by frequently associated gastroesophageal reflux. In this context, symptoms of asthma (or bronchial hyperreactivity) occur more frequently than in the general population and persist into adulthood. Their pathogenesis is still poorly understood and is the subject of much discussion. The therapeutic management of these respiratory complications, poorly codified, remains very heterogeneous from one center to another. In France, the summary of knowledge is updated by the Reference Center for chronic and malformative diseases of the esophagus.

Conditions

Esophageal Atresia

Keywords

esophageal atresia; esophageal malformation; gastroesophageal reflux; asthma; bronchial hyperreactivity

Outcome Measures

Primary Outcomes (1)

• Retrospective study of respiratory complications of esophageal atresia in children

  Files analysed retrospectively from January 01, 2010 to December 31, 2020 will be examined

Eligibility Criteria

• Age: 1 Year - 12 Years
• Sex: all
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Child aged 1 to 12 years old operated on for esophageal atresia and followed up at the University Hospitals of Strasbourg

You may qualify if:

• Child aged 1 to 12 years old
• Child operated on for esophageal atresia between 01/01/2010 and 31/12/2020 and followed up at the University Hospitals of Strasbourg
• Child who has not expressed, after being informed, his opposition to the reuse of his data for the purposes of this research
• Parental authority having not expressed, after being informed, their opposition to the reuse of their child's data for the purposes of this research.

You may not qualify if:

• Subject and/or parental authority having expressed their opposition to participating in the study

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Centre de Ressources et de Compétences de la Mucoviscidose (CRCM) - CHU de Strasbourg - France

Strasbourg, 67091, France

Location

MeSH Terms

Conditions

Esophageal Atresia; Gastroesophageal Reflux; Asthma; Bronchial Hyperreactivity

Condition Hierarchy (Ancestors)

Digestive System Abnormalities; Digestive System Diseases; Esophageal Diseases; Gastrointestinal Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Esophageal Motility Disorders; Deglutition Disorders; Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Laurence WEISS, MD

  Centre de Ressources et de Compétences de la Mucoviscidose (CRCM) - CHU de Strasbourg - France

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 1, 2022
• First Posted: September 6, 2022
• Study Start: March 16, 2022
• Primary Completion: October 16, 2022
• Study Completion: December 16, 2022
• Last Updated: November 8, 2023

Record last verified: 2023-11

Locations

FR (1)