National Register of Oesophageal Atresia
REGATE
3 other identifiers
observational
1,460
3 countries
37
Brief Summary
The esophageal atresia is a group of birth defects including a break in continuity of the esophagus with or without persistent communication with the trachea (tracheoesophageal fistula), sometimes associated (from 50%) of other malformations (heart, kidney, digestive ...). The current prognosis for this ailment is good. However he persists a mortality (\<10%) and significant morbidity, firstly related malformations (heart, kidney, for example), and secondly with particularly difficult anatomical forms (Forms long defect) . The prevalence of this condition is estimated to be 1/2500 in 3000 live births, making an estimated ± 2,500 new cases over to 10 years in France. The current project aims to set up a national registry (Metropolitan France and Dom Tom) to measure the prevalence of esophageal atresia among live births, phenotypic characteristics, the circumstances of their diagnosis, and their initial future at short-term during the first year of life, at which time occurs the vast majority of deaths and complications in this disease.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2008
Longer than P75 for all trials
37 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2008
CompletedFirst Submitted
Initial submission to the registry
August 18, 2016
CompletedFirst Posted
Study publicly available on registry
August 30, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2019
CompletedMay 5, 2026
April 1, 2026
9 years
August 18, 2016
April 29, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Number of esophageal atresia
10 years
Secondary Outcomes (3)
Data collection patient with esophageal atresia
10 years
Total number of patients with complications
10 years
Death
10 years
Study Arms (1)
Esophageal atresia
Interventions
Eligibility Criteria
All living newborns having a esophageal atresia supported in a neonatal unit, neonatal intensive care and pediatric surgery of France
You may qualify if:
- To be born in France
- To have a esophageal atresia
You may not qualify if:
- To be born abroad
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (37)
CHU Félix-Guyon
Saint-Denis, La Réunion, France
CHU Amiens-Picardie
Amiens, France
CHU d'Angers
Angers, France
CHRU Besançon
Besançon, France
CHU de Bordeaux
Bordeaux, France
CHRU Brest
Brest, France
HFME de Lyon
Bron, France
CHU de Caen
Caen, France
CHU de Clermont-Ferrand
Clermont-Ferrand, France
Hôpitaux Civils de Colmar
Colmar, France
CHI Créteil
Créteil, France
CHU Dijon Bourgogne
Dijon, France
CHU de Grenoble
La Tronche, France
AP-HP CHU Kremlin-Bicêtre
Le Kremlin-Bicêtre, France
CH Le Mans
Le Mans, France
CHRU,Hôpital Jeanne de Flandres
Lille, France
CHU de Limoges
Limoges, France
AP-HM La Timone
Marseille, France
AP-HM Nord
Marseille, France
CHRU de Montpellier
Montpellier, France
CHU de Nantes
Nantes, France
CHU de Nice
Nice, France
CHR d'Orléans
Orléans, France
AP-HP Armand Trousseau
Paris, France
AP-HP Necker-Enfants malades
Paris, France
AP-HP Robert-Debré
Paris, France
CHU de Poitiers
Poitiers, France
CHU de Reims
Reims, France
CHU de Rennes
Rennes, France
CHU de Rouen
Rouen, France
CHU de Saint-Etienne
Saint-Priest-en-Jarez, France
CHU de Strasbourg
Strasbourg, France
CHU de Toulouse
Toulouse, France
CHRU de Tours
Tours, France
CHU de Nancy
Vandœuvre-lès-Nancy, France
CHU de Pointe-à-Pitre
Pointe-à-Pitre, Guadeloupe
CHU de Martinique
Fort-de-France, 97200, Martinique
Related Publications (1)
Lejeune S, Sfeir R, Rousseau V, Bonnard A, Gelas T, Aumar M, Panait N, Rabattu PY, Irtan S, Fouquet V, Le Mandat A, Cocci SN, Habonimana E, Lamireau T, Lemelle JL, Elbaz F, Talon I, Boudaoud N, Allal H, Buisson P, Petit T, Sapin E, Lardy H, Schmitt F, Levard G, Scalabre A, Michel JL, Jaby O, Pelatan C, De Vries P, Borderon C, Fourcade L, Breaud J, Arnould M, Tolg C, Chaussy Y, Geiss S, Laplace C, Drumez E, El Mourad S, Thumerelle C, Gottrand F. Esophageal Atresia and Respiratory Morbidity. Pediatrics. 2021 Sep;148(3):e2020049778. doi: 10.1542/peds.2020-049778. Epub 2021 Aug 19.
PMID: 34413249RESULT
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Frédéric Gottrand, MD, PhD
University Hospital, Lille
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 18, 2016
First Posted
August 30, 2016
Study Start
January 1, 2008
Primary Completion
December 31, 2016
Study Completion
December 31, 2019
Last Updated
May 5, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will not share