Study of the Impact of Exposure to Outdoor and Indoor Pollutants in Patients With Asthma

NCT05525169 | Recruiting

• 1 other identifier: RC22_0115
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The project is to measure exposure to outdoor and indoor air pollutants in asthma patients in order to show a possible association between variation in pollutant exposure and the occurrence of exacerbations in these patients

Conditions

Asthma

Keywords

Asthma; exacerbations; outdoor and indoor air pollutants

Outcome Measures

Primary Outcomes (1)

• Asthma exacerbations

  The primary criterion is the association between the occurrence of exacerbations and the concentrations of the following pollutants or other environmental factors measured daily in the patients' homes by air pollution sensor inside and outside the home. * the concentration of indoor pollutants: PM1 (µg/m3), PM2.5 (µg/m3), PM10 (µg/m3), volatile organic compounds (VOC) (µg/m3) , CO2 (ppm), * the concentration of outdoor pollutants (µg/m3): PM1, PM2.5, PM10, * The ratios (indoor/outdoor air) of PM1, PM2.5 and PM10 in the home, * Temperature(°C) and relative humidity (RH) (%) in indoor and outdoor air, * Exceedances of regulatory (provided by the Environmental Code) or recommended (determined by the sensor supplier) pollutant thresholds.

  36 months

Secondary Outcomes (1)

• Daily Peak flow (l/ min)

  36 months

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of adult men and women recruited from the active file of asthma patients followed at the Nantes University Hospital, the Saint Nazaire Hospital, the Châteaubriant Nozay Pouancé Hospital and the Erdre et Loire Hospital. Regardless of the type of asthma, patients will be potentially included if they have a minimum of 4 exacerbations during the year preceding inclusion in the EXAP project\>. Participation in other non-interventional research is allowed during the study unless this research increases the number of exacerbations.

You may qualify if:

• Patient over 18 years of age,
• Patient with a confirmed diagnosis of asthma for at least 12 months as defined by the investigator,
• Patient with at least 4 asthma exacerbations in the last year
• Patient sleeping at least 6 nights per week in the same home

You may not qualify if:

• Patient who is an active smoker or living with an active smoker,
• Patient with a diagnosis of COPD, ABPA or associated pulmonary fibrosis,
• Patient with known occupational exposure,
• Patient living in a dwelling that does not allow the installation of sensors (inability to connect the sensor to the power supply, no location for the outdoor sensor...)
• Patient who plans to move in the next 6 months,
• Patient with a life expectancy of less than 6 months,
• Patient who has someone living in their household also included in EXAP,
• Patient who lives in an apartment and does not have a balcony or space for the outdoor sensor,
• Pregnant or breastfeeding women,

Sponsors & Collaborators

• Nantes University Hospital: lead

Study Sites (1)

CHU de Nantes

Nantes, 44093, France

RECRUITING

MeSH Terms

Conditions

Asthma

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• François-Xavier Blanc, PU-PH

  Nantes University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

François-Xavier Blanc, PU-PH

CONTACT

02 40 16 53 33; xavier.blanc@chu-nantes.fr

Megguy Bernard

CONTACT

megguy.bernard@chu-nantes.fr

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 7, 2022
• First Posted: September 1, 2022
• Study Start: November 15, 2022
• Primary Completion (Estimated): November 15, 2026
• Study Completion (Estimated): November 15, 2026
• Last Updated: April 17, 2026

Record last verified: 2026-04

Locations

FR (1)