Investigation of Knee Hyperextension and Femoral Cartilage Thickness in Chronic Stroke Patients

NCT05513157 | Completed

• 1 other identifier: E-59394181-604.01.02-37185
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

It is aimed to measure knee hyperextension and knee joint cartilage thickness in chronic stroke patients and to examine the relationship between the factors affecting knee hyperextension and knee joint cartilage thickness. This study, it is aimed to compare the knee joint cartilage thicknesses of the affected and unaffected extremities and to examine the relationship between knee hyperextension and knee joint cartilage thickness. The second aim is to compare the knee joint cartilage thickness of the paretic and nonparetic extremities and in stroke patients with and without knee hyperextension. The hypotheses of the study are: Hypothesis 1; H0: There is no difference between the knee joint cartilage thickness of the affected and unaffected extremities in chronic stroke patients with knee hyperextension. H1: In chronic stroke patients with knee hyperextension, there is a difference between the knee joint cartilage thicknesses of the affected and unaffected extremities. Hypothesis 2; H0: There is no relationship between knee hyperextension during the stance phase of gait and knee joint cartilage thickness in chronic stroke patients. H1: There is a relationship between knee hyperextension during the stance phase of gait and knee joint cartilage thickness in chronic stroke patients. Hypothesis 3; H0: There is no relationship between lower extremity muscle strength and spasticity and knee joint cartilage thickness in chronic stroke patients with knee hyperextension. H1: There is a relationship between lower extremity muscle strength and spasticity and knee joint cartilage thickness in chronic stroke patients with knee hyperextension. Hypothesis 4; H0: There is no difference between the cartilage thickness of the knee joint in chronic stroke patients with and without knee hyperextension. H1: There is a difference between the cartilage thickness of the knee joint in chronic stroke patients with and without knee hyperextension.

Conditions

Stroke

Keywords

Stroke; Gait Analysis; Cartilage; Knee; Thickness; Ultrasonography

Outcome Measures

Primary Outcomes (2)

• Movement Analysis

  Reflective signs will be placed on certain anatomical points on the participants and participants will be asked to walk at a distance of 5 meters. The three-dimensional positions of these reflective marks will be captured by the 8-camera Vicon motion capture system and recorded in the computer environment using Blade software.

  Baseline

• Ultrasonography

  Ultrasonographic evaluations were made by the same investigator using a linear/convex probe. In the supine position, with the knees fully flexed, the linear probe was placed axially in the suprapatellar region, and the distal femoral cartilage thickness was measured from the midpoints of the lateral femoral condyle, intercondylar area and medial femoral condyle. Outcome values were determined by taking the average of three consecutive measurements.

  Baseline

Secondary Outcomes (2)

• Muscle Strength Assessment

  Baseline

• Spasticity Assessment

  Baseline

Study Arms (2)

Chronic stroke patients with knee hyperextension

Chronic stroke patients with a maximum knee extension angle of less than 0 degrees in movement analysis

Chronic stroke patients without knee hyperextension

Chronic stroke patients with a maximum knee extension angle greater than 0 degrees in movement analysis

Eligibility Criteria

• Age: 40 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Stroke Patients

You may qualify if:

• Being between the ages of 40-65
• At least 6 months have passed since the stroke
• Ambulation with or without a walking aid (walker, cane, or tripod)
• Being between 0-3 points according to the Modified Rankin Score
• Getting a score of 24 or higher on the Mini Mental Test
• Volunteering to participate in the study

You may not qualify if:

• Having a history of more than one stroke
• Known presence of dementia
• Having a known orthopedic, psychiatric or other neurological disease
• Having a situation that prevents communication
• Having a history of surgery involving lower extremities and gait

Sponsors & Collaborators

• Hacettepe University: lead
• Atılım University: collaborator

Study Sites (1)

Hacettepe University

Altindağ, Ankara, 06100, Turkey (Türkiye)

Location

Related Publications (4)

• Tunc H, Oken O, Kara M, Tiftik T, Dogu B, Unlu Z, Ozcakar L. Ultrasonographic measurement of the femoral cartilage thickness in hemiparetic patients after stroke. Int J Rehabil Res. 2012 Sep;35(3):203-7. doi: 10.1097/MRR.0b013e3283532736.

  PMID: 22555317 BACKGROUND

• Yalcin S, Kara M, Ozturk GT, Ozcakar L. Ultrasonographic measurements of the metacarpal and talar cartilage thicknesses in hemiplegic patients after stroke. Top Stroke Rehabil. 2017 Jan;24(1):1-4. doi: 10.1080/10749357.2016.1183357. Epub 2016 May 9.

  PMID: 27159891 BACKGROUND

• Cooper A, Alghamdi GA, Alghamdi MA, Altowaijri A, Richardson S. The relationship of lower limb muscle strength and knee joint hyperextension during the stance phase of gait in hemiparetic stroke patients. Physiother Res Int. 2012 Sep;17(3):150-6. doi: 10.1002/pri.528. Epub 2011 Dec 7.

  PMID: 22147298 BACKGROUND

• Korkusuz S, Kibar S, Ozgoren N, Aritan S, Seckinogullari B, Balkan AF. Effect of Knee Hyperextension on Femoral Cartilage Thickness in Stroke Patients. Am J Phys Med Rehabil. 2024 May 1;103(5):371-376. doi: 10.1097/PHM.0000000000002323.

  PMID: 37549370 DERIVED

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Kadriye Armutlu, Prof.Dr.

  Hacettepe University

  STUDY CHAIR

• Süleyman Korkusuz, MSc.

  Hacettepe University

  PRINCIPAL INVESTIGATOR

• Sibel Kibar, Assoc.Prof.

  Atılım University

  STUDY CHAIR

• Büşra Seçkinoğulları, MSc

  Hacettepe University

  STUDY CHAIR

• Serdar Arıtan, Assist.Prof.

  Hacettepe University

  STUDY CHAIR

• Nihat Özgören, MSc

  Hacettepe University

  STUDY CHAIR

• Ayla Fil Balkan, Assoc.Prof

  Hacettepe University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 21, 2022
• First Posted: August 24, 2022
• Study Start: August 15, 2022
• Primary Completion: January 20, 2023
• Study Completion: February 1, 2023
• Last Updated: June 13, 2023

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)