The Effect of Oxygen Therapy on Atelectasis

NCT05509764 | Completed

• 1 other identifier: 2021/02
• Study Type: observational
• Target: 1
• Locations: 1 country
• Sites: 2

Brief Summary

In pregnancy, cephalal shift of the diaphragm caused by the enlarged uterus reduces the functional residual capacity and may increase the closure volume and predispose the pregnant woman to airway closure, leading to atelectasis. The development of atelectasis due to dermatomes retained in spinal anesthesia and intraoperative supine position may increase further. Oxygen therapy to be applied may also lead to absorption atelectasis by causing hyperoxia. The aim of our study is to evaluate the effect of oxygen support on the lungs in cesarean section operations under spinal anesthesia by lung ultrasound score and oxygen reserve index.

Conditions

Atelectasis; Cesarean Section; Hypotension

Keywords

Atelectasis; lung ultrasound; oxygen reserve index; cesarean section

Outcome Measures

Primary Outcomes (1)

• atelectasis

  measuring atelectasis due to oxygen therapy

  during the surgery

Secondary Outcomes (2)

• APGAR score

  1st and 5th min after delivery

• hypotension

  during surgery

Study Arms (3)

group 0

control group

Diagnostic Test: lung ultrasound score

group 3

3 Lt/min Oxygen therapy via nasal cannula

Diagnostic Test: lung ultrasound score

group 6

6 Lt/min Oxygen therapy via Simple face mask

Diagnostic Test: lung ultrasound score

Interventions

lung ultrasound score DIAGNOSTIC_TEST

determination of atelectasis by lung ultrasound score

group 0; group 3; group 6

Eligibility Criteria

• Age: 18 Years - 47 Years
• Gender Eligibility Details: parturients who underwent cesarean section under spinal anesthesia
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

parturients who underwent cesarean section under spinal anesthesia

You may qualify if:

• years old
• ASA I-II
• Patients scheduled for elective cesarean section under spinal anesthesia

You may not qualify if:

• alcohol or drug addiction, chronic obstructive pulmonary disease, cardiovascular disease, smokers anemia, liver or kidney disease, coagulation disorders allergic to anesthetic agents, sepsis or bacterial infection, body temperature is below 35°C and above 38°C Multiple pregnancy Preoperative hypoxemia SpO2\<94% Diabetes mellitus Hypertension Placenta previa Premature rupture of membranes Intrauterine growth retardation Preeclampsia-eclampsia-fetal distress Polyhydramnios Morbid obesity BMI\>45

Sponsors & Collaborators

• Zonguldak Bulent Ecevit University: lead

Study Sites (2)

Manolya Alkan

Zonguldak, Kozlu, 67600, Turkey (Türkiye)

Location

Zonguldak Bülent Ecevit University Medicine Faculty

Zonguldak, Kozlu, 67600, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pulmonary Atelectasis; Hypotension

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiologist

Study Record Dates

• First Submitted: August 18, 2022
• First Posted: August 22, 2022
• Study Start: May 1, 2021
• Primary Completion: March 1, 2022
• Study Completion: August 1, 2022
• Last Updated: August 26, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will share

Locations

TU (2)