NCT05509101

Brief Summary

The purpose of this study is to improve control of myoelectrically-controlled advanced orthotic devices (an exoskeleton device that use the body's muscle signals to drive movements of a robotic brace) by using advanced predictive decode algorithms, and the use of high count (\> 8) surface electromyographic (sEMG) electrodes.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
45

participants targeted

Target at P25-P50 for not_applicable

Timeline
17mo left

Started Mar 2017

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress87%
Mar 2017Dec 2027

Study Start

First participant enrolled

March 1, 2017

Completed
5.5 years until next milestone

First Submitted

Initial submission to the registry

August 15, 2022

Completed
4 days until next milestone

First Posted

Study publicly available on registry

August 19, 2022

Completed
5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 31, 2027

Expected
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2027

Last Updated

May 6, 2026

Status Verified

April 1, 2026

Enrollment Period

10.4 years

First QC Date

August 15, 2022

Last Update Submit

April 29, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Box and Blocks Test (BBT)

    The Box and Blocks test is performed using the orthotic device under each condition. The individual puts on the device for a maximum of two hours. During that time wearing the device, they will use two different algorithms for controlling the device to complete the Box and Blocks Test.

    while using the device (up to 2 hours)

Study Arms (2)

Clinically Available Control Algorithm (MyoPro)

ACTIVE COMPARATOR

Binary control of the orthosis is based on a clinically available control algorithm. This condition serves as a control. Participants will use a commercially available device, the MyoPro.

Other: commercially available control algorithm

High-Density EMG Control Algorithm

EXPERIMENTAL

Control of the orthosis is based on residual muscle activity mapped to intended movement using advanced predicted algorithms. This condition is a novel algorithm and serves as the experimental condition.

Other: experimental control algorithm

Interventions

Control of the prosthesis/orthosis is based on clinical standard of care using commercially available control algorithms.

Clinically Available Control Algorithm (MyoPro)

Control of the orthosis is based on residual muscle activity mapped to intended movement using high density electromyography and artificial intelligence control algorithms.

High-Density EMG Control Algorithm

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • First-ever ischemic or hemorrhagic stroke
  • Chronic Stroke (at least 6 months since onset)
  • Chronic hemiparesis
  • Functional range of motion for contralateral arm

You may not qualify if:

  • Individuals who are currently Incarcerated

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Utah

Salt Lake City, Utah, 84132-2101, United States

RECRUITING

MeSH Terms

Conditions

Paresis

Condition Hierarchy (Ancestors)

Neurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
OTHER
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

August 15, 2022

First Posted

August 19, 2022

Study Start

March 1, 2017

Primary Completion (Estimated)

July 31, 2027

Study Completion (Estimated)

December 31, 2027

Last Updated

May 6, 2026

Record last verified: 2026-04

Locations