Impact of the Early Use of High Flow Nasal Cannula in Patients With Post-traumatic Lung Contusion, a Randomized Clinical Trial

NCT05509088 | Unknown

• 1 other identifier: FAMSU R 116/ 2022
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

We hypothesize that early and continuous administration of oxygen via high flow nasal cannula in patients with lung contusion and non-severe acute lung injury might reduce the incidence of intubation and hold the deterioration of pulmonary functions.

Conditions

Traumatic Lung Injury

Outcome Measures

Primary Outcomes (1)

• need for intubation and mechanical ventilation within 28 days of randomization.

  the incidence of intubation in patients with lung contusion who receive oxygen through high flow nasal cannula

  3 months

Study Arms (2)

high flow nasal cannula

EXPERIMENTAL

will receive oxygen through high flow nasal cannula

Device: high flow nasal cannula

oxygen mask

NO INTERVENTION

will receive oxygen through oxygen mask

Interventions

high flow nasal cannula DEVICE

Patients in the intervention group receive oxygen through HFNC with a flow rate of set initially at 40 L / min, FiO2 adjusted to maintain SpO2 ≥ 92%, and will be humidified, heated to 34-37 °C, disconnection will be allowed only when ambulation is required, patients will be instructed to practice mouth closing throughout the HFNC therapy as much as possible

high flow nasal cannula

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Willing and able to provide written informed consent prior to performing study procedures, currently hospitalized and requiring medical care for blunt chest trauma, within 24h of trauma

You may not qualify if:

• face trauma or surgery, airway obstruction, known to have chronic chest condition

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain Shams University hospitals

Cairo, 11591, Egypt

RECRUITING

MeSH Terms

Conditions

Lung Injury

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Thoracic Injuries; Wounds and Injuries

Central Study Contacts

amr hafez, M.D

CONTACT

01225674370; amr_foud@med.asu.edu.eg

farouk Kamal, M.D

CONTACT

faroukkamal@med.asu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 18, 2022
• First Posted: August 19, 2022
• Study Start: July 28, 2022
• Primary Completion: December 28, 2022
• Study Completion: December 28, 2022
• Last Updated: August 19, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)