Messages About Reduced Nicotine in Combusted Tobacco Products
1 other identifier
interventional
1,901
1 country
1
Brief Summary
The investigators will conduct a message-exposure experiment with nationally representative samples of smokers, dual-users (cigarettes and e-cigarettes), and young adult non-smokers (aged 18-29). Experimental messages will address the reduction of nicotine in cigarettes. Participants will also complete a follow-up survey after 2 weeks, measuring their recall of the messages and behaviors since message exposure.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Oct 2022
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 16, 2022
CompletedFirst Posted
Study publicly available on registry
August 18, 2022
CompletedStudy Start
First participant enrolled
October 12, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 28, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
February 28, 2023
CompletedResults Posted
Study results publicly available
August 28, 2024
CompletedAugust 28, 2024
August 1, 2024
5 months
August 16, 2022
February 13, 2024
August 8, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Perceived Health Risk of VLNCs (Absolute)
Measured with a single item, assesses participant's perception of own risk of overall harm to health under conditions of smoking reduced nicotine cigarettes every day. Response options range from 1 (Not at all likely) to 5 (Extremely likely), with higher scores representing a better outcome. An additional option, "Don't know", is also provided.
Immediately after exposure
Secondary Outcomes (8)
Interest in Trying Reduced Nicotine Cigarettes
Immediately after exposure
Intention to Switch From Cigarettes to Electronic Nicotine Products
Immediately after exposure
Perceived Addictiveness of VLNCs
Immediately after exposure
VLNC Comparative Risk Perceptions
Immediately after exposure
VLNC Policy Support
Immediately after exposure
- +3 more secondary outcomes
Study Arms (4)
Reduced Nicotine Messages
EXPERIMENTALParticipants will receive messages with information about reduced nicotine cigarettes.
Modified Risk Messages
EXPERIMENTALParticipants will receive messages with information about e-cigarettes.
Combined Message -- Reduced Nicotine + Modified Risk Exposure
EXPERIMENTALParticipants will receive messages about reduced nicotine cigarettes and about e-cigarettes.
Control
OTHERParticipants will receive messages about bottled water which should have no impact on the outcomes of interest.
Interventions
Participants will be shown two messages about harms of reduced nicotine cigarettes. The two messages will be drawn from a pool of five messages. The messages will communicate that reduced nicotine cigarettes will still have the rest of the harmful chemicals and cause diseases as the regular cigarettes, but they would make it easier to quit.
Participants will be shown two messages about electronic cigarettes as an alternative to regular cigarettes. The two messages will be drawn from a pool of five messages. The messages will communicate that electronic cigarettes are less likely than regular cigarettes to cause severe diseases such as lung cancer.
Participants will be shown two messages, one from the reduced nicotine message set and one modified risk message set.
Participants will be shown two messages about drinking bottled water. These will be selected from a pool of five message. The messages display specific water products and describe hydration as a healthy activity.
Eligibility Criteria
You may qualify if:
- Being 18 years old or older:
- Belonging to one of three groups of participants; 900 current exclusive smokers, 450 dual users (cigarettes and e-cigarettes), and 450 young adult (18-29) non-smokers, evenly split between men and women.
- Enrolled in existing nationally representative panel where recruitment is based
You may not qualify if:
- \- None.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Georgia State University
Atlanta, Georgia, 30302, United States
Related Publications (1)
Pei D, Reynolds RM, Ntansah CA, Hackworth EE, Henderson KC, Yang B, Duong HT, Ashley DL, Thrasher JF, Popova L. Independent and combined effects of very low nicotine cigarette messages and e-cigarette messages: a randomised clinical trial. Tob Control. 2025 Dec 19;34(e1):e48-e56. doi: 10.1136/tc-2023-058556.
PMID: 38664002DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Lyudmila Popova
- Organization
- Georgia State University
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
August 16, 2022
First Posted
August 18, 2022
Study Start
October 12, 2022
Primary Completion
February 28, 2023
Study Completion
February 28, 2023
Last Updated
August 28, 2024
Results First Posted
August 28, 2024
Record last verified: 2024-08
Data Sharing
- IPD Sharing
- Will not share