Effects of Postoperative Analgesic Modalities on Plasma Creatine Phosphokinase(CPK) Levels After Knee Artroplasty
1 other identifier
observational
82
1 country
1
Brief Summary
Regional anesthesia and analgesia technics are widely and securely used during orthopedic surgery. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. We aimed to examine plasma CPK(creatine phosphokinase) levels to see whether myotoxicity occurs or not after suprainguinal fascial plane block is applied to patients undergoing knee artroplasty surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Dec 2022
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 15, 2022
CompletedFirst Posted
Study publicly available on registry
August 18, 2022
CompletedStudy Start
First participant enrolled
December 16, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 21, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
February 21, 2023
CompletedFebruary 22, 2023
February 1, 2023
2 months
August 15, 2022
February 21, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
CPK levels
Change from Baseline serum creatine phosphokinase at 24 hours
at postoperative 24th hour
Secondary Outcomes (1)
Number of patients requesting rescue analgesics
up to 24 hours
Study Arms (2)
SFIPB
suprainguinal fascia iliaca plane block with 50ml of %0.25 bupivacaine will be used for postoperative analgesia .
control
Fascia iliac block will not be applied to this group. Postoperative analgesia will be provided with other analgesia modalities.
Interventions
Suprainguinal fascia iliaca block will be performed after the end of surgery for postoperative analgesia.
Eligibility Criteria
Patients undergoing knee artroplasty surgery of ASA status 1-3. aged between 18-75years.
You may qualify if:
- ASA 1-3
- knee artoplasty patients
- under spinal anesthesia
You may not qualify if:
- local anesthetic allergies
- myopathies
- coagulopathies
- Obstructive sleep apne syndrome
- hearth diseases
- liver diseases
- kidney diseases
- thyroid-parathyriod dieseas
- hiperlipidemias using Statins(HMG-CoA reductase inhibitors)
- pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Samsun University
Samsun, Turkey (Türkiye)
Related Publications (1)
Rakhi V, Kaushal S, Singh S. Measurement of bupivacaine induced myotoxicity in interfascial plane blocks: A randomised controlled trial. Indian J Anaesth. 2021 Dec;65(12):886-891. doi: 10.4103/ija.ija_848_21. Epub 2021 Dec 22.
PMID: 35221361RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Serkan Tulgar
Samsun University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 15, 2022
First Posted
August 18, 2022
Study Start
December 16, 2022
Primary Completion
February 21, 2023
Study Completion
February 21, 2023
Last Updated
February 22, 2023
Record last verified: 2023-02
Data Sharing
- IPD Sharing
- Will not share