CPK Levels After LC and Association With Analgesic Modalities

NCT06508177 | Completed

• 1 other identifier: SamsunU_LapCholecyst_CK
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Regional anesthesia and analgesia technics are widely and securely used during general surgery procedures. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. The investigators aimed to examine plasma creatine phosphokinase (CPK) levels to see whether myotoxicity occurs or not after fascial plane blocks are applied to patients undergoing laparoscopic cholecystectomy.

Conditions

Myotoxicity

Keywords

creatine phosphokinase; cholecystectomy; interfascial plane blocks

Outcome Measures

Primary Outcomes (1)

• CPK levels

  Serum creatine phosphokinase levels at 24th hour

  at postoperative 24th hour

Study Arms (2)

Interfascial plane blocks

Patients who are preferred to apply interfascial plane blocks as part of multimodal analgesia in the postoperative analgesia plan will be evaluated in this group.

Other: İnterfascial plane block; Other: Standart analgesia plan

Control

Multimodal analgesia plans that does not include interfascial plane blocks

Other: Standart analgesia plan

Interventions

İnterfascial plane block OTHER

Interfascial plane blocks will be added to the routine analgesia plan as part of multimodal analgesia.

Interfascial plane blocks

Standart analgesia plan OTHER

This is the routine analgesia plan applied in our clinic.

Control; Interfascial plane blocks

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients who underwent laparoscopic cholecystectomy ASA 1-3. age:18-70

You may qualify if:

• ASA 1-3
• Laparoscopic cholecystectomy
• under General Anesthesia

You may not qualify if:

• Morbidly obesity or cachexia
• local anesthetic allergies
• myopathies
• coagulopathies
• Obstructive sleep apne syndrome
• hearth diseases
• liver diseases
• kidney diseases
• thyroid-parathyriod dieseas
• hiperlipidemias using Statins(HMG-CoA reductase inhibitors)
• pregnancy

Sponsors & Collaborators

• Samsun University: lead

Study Sites (1)

Samsun University

Samsun, Turkey (Türkiye)

Location

Related Publications (1)

• Rakhi V, Kaushal S, Singh S. Measurement of bupivacaine induced myotoxicity in interfascial plane blocks: A randomised controlled trial. Indian J Anaesth. 2021 Dec;65(12):886-891. doi: 10.4103/ija.ija_848_21. Epub 2021 Dec 22.

  PMID: 35221361 BACKGROUND

MeSH Terms

Conditions

Myotoxicity

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Diseases; Nervous System Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Drug-Related Side Effects and Adverse Reactions; Chemically-Induced Disorders; Radiation Injuries; Wounds and Injuries

Study Officials

• Serkan Tulgar

  Samsun University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 12, 2024
• First Posted: July 18, 2024
• Study Start: August 5, 2024
• Primary Completion: March 30, 2025
• Study Completion: March 30, 2025
• Last Updated: June 24, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)