NCT05503212|Completed
Best Revascularisation Approach for Posterior Circulation Strokes With Isolated Vertebral Artery Occlusions
BRAVO
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BRAVO
Sponsor study identifier
observational
682
1 country
1
Study Start
January 1, 2003
Actual (reported)Primary Completion
August 9, 2023
Actual (reported)Study Completion
August 9, 2023
Actual (reported)Isolated vertebral artery occlusions (VAO) account for approximately one third of posterior circulation occlusions, but have been given the least attention among posterior circulation strokes. If the two recent ATTENTION and BAOCHE randomized clinical trials have proven the superiority of endovascular thrombectomy (EVT) in basilar artery occlusions, data on the effectiveness and harm of acute revascularization treatment on isolated VAO is scarce. We aim to investigate the impact of acute recanalisation treatments in acute ischemic stroke patients with isolated VAO. In the absence of RCT, observational data with appropriate statistical methods may give indications on benefits and harms of treating neglected stroke situations like acute vertebral occlusion. Results may also lay the basis for prospective studies, such as randomized clinical trials.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 9, 2023
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1, 2003
Actual (reported)March 22, 2022
Actual (reported)August 16, 2022
Actual (reported)August 9, 2023
Actual (reported)August 9, 2023
Actual (reported)3-month modified Rankin scale
3-month functional outcome, \[range: 0-6, 0= no symptoms, 6=death\]
90 days
Symptomatic intracerebral haemorrhage (sICH)
7 days
EVT procedural complications
During EVT procedure or peri-procedural
24-hour NIHSS
Patients with acute ischemic stroke (AIS) and concomitant isolated intracranial and/or extracranial vertebral artery occlusion (VAO)
Best medical treatment without intravenous thrombolysis nor endovascular thrombectomy
Best medical treatment with intravenous thrombolysis but without endovascular thrombectomy
Patients with acute ischemic stroke and concomitant isolated vertebral artery occlusion accounting for stroke symptoms
Centre Hospitalier Universitaire Vaudois
Lausanne, Canton of Vaud, 1011, Switzerland
Dr. med. Alexander Salerno, MD
CHUV
682 participants (actual enrollment reported by the registry).
First Submitted
March 22, 2022
First Posted
August 16, 2022
Study Start
January 1, 2003
Actual (reported)Argatroban Stroke Treatment - A Pilot Safety Study
24 hours
Early neurological deterioration (ENDi)
24 hours
Cerebrovascular ischemic recurrences
90 days
Best medical treatment with endovascular thrombectomy with or without intravenous thrombolysis
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Primary Completion
August 9, 2023
Actual (reported)Study Completion
August 9, 2023
Actual (reported)Last Updated
August 14, 2023
Record last verified: 2023-08
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Source: ClinicalTrials.gov.
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