Color Doppler Ultrasound in Lacrimal Sac Space-occupying Lesions

NCT05500950 | Completed

• 1 other identifier: CDU in lacrimal sac
• Study Type: observational
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

Dacryocystitis and nasolacrimal duct obstruction are the main common causes of epiphora. Dacryocystorhinostomy (DCR) is a widely used and effective treatment for dacryocystitis and nasolacrimal duct obstruction. Among these cases, some patients have space-occupying lesions in the lacrimal sac area, such as dacryoliths, mucoceles, granulomas, and even tumors. For patients with lacrimal sac tumors, a more complex treatment plan needs to be adopted, and the severity of the disease and the complexity of treatment should be informed before surgery, since more than 55% of lacrimal sac tumors are malignant. Therefore, preoperative diagnosis and identification of lacrimal sac space-occupying lesions is important. For lack of imaging examinations, and the symptoms of patients with space-occupying lesions are often similar to those of dacryocystitis and nasolacrimal duct obstruction, which lead to the diagnosis of lacrimal sac space-occupying lesions was not discovered before DCR. CDU has been used for the observation of lacrimal gland tumors. This study has attempted to assess the CDU and CT dacryocystography characteristics of the lacrimal sac space-occupying lesions.

Conditions

Dacryocystitis; Chronic; Lacrimal Sac Space-occupying Lesions; Color Doppler Ultrasound; Computed Tomography

Keywords

Color Doppler ultrasound; lacrimal sac space-occupying lesions; nasolacrimal duct obstruction; Computed Tomography

Outcome Measures

Primary Outcomes (1)

• Morphological changes of color Doppler ultrasound in lacrimal sac space-occupying lesions

  Conventional ultrasonography and color Doppler ultrasonography images are used to assess the characteristics of lacrimal sac space-occupying lesions. Percentage of patients with clear or unclear borders, even or uneven internal echogenicity, regular or irregular shape, with or without blood flow signals of different kinds of lacrimal sac space-occupying lesions was recorded.

  2 weeks before surgery

Secondary Outcomes (1)

• Morphological changes of CT or CT-DCG in lacrimal sac space-occupying lesions

  2 weeks before surgery

Study Arms (1)

Patients with space occupying lesions completed CDU and CT-DCG or CT

Patients who had completed CDU and CT-DCG or CT examination before surgery and were diagnosed with lacrimal sac space occupying lesions during surgery were selected to be included in this study.

Other: CDU and CT-DCG or CT examination

Interventions

CDU and CT-DCG or CT examination OTHER

patients with space occupying lesions in the lacrimal sac area completed CDU and CT-DCG or CT examination before surgery

Patients with space occupying lesions completed CDU and CT-DCG or CT

Eligibility Criteria

• Age: 10 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

21 patients who had completed color Doppler ultrasound and CT dacryocystography or CT examination before surgery and were diagnosed with lacrimal sac space-occupying lesions during EEDCR surgery were enrolled in this study.

You may qualify if:

• Clinical diagnosis of lacrimal sac space-occupying lesion. Lacrimal sac surgery must be completed. Must had completed color Doppler ultrasound and CT dacryocystography or CT examination before surgery.

You may not qualify if:

• Preoperative ultrasound or CT examination not completed.

Sponsors & Collaborators

• Wenzhou Medical University: lead

Study Sites (1)

Eye Hospital and School of Ophthalmology and Optometry,Wenzhou Medical University

Wenzhou, Zhejiang, 321000, China

Location

MeSH Terms

Conditions

Dacryocystitis; Bronchiolitis Obliterans Syndrome; Lacrimal Duct Obstruction

Condition Hierarchy (Ancestors)

Lacrimal Apparatus Diseases; Eye Diseases; Organizing Pneumonia; Bronchiolitis Obliterans; Bronchiolitis; Bronchitis; Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Graft vs Host Disease; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Chief Physician

Study Record Dates

• First Submitted: July 8, 2022
• First Posted: August 15, 2022
• Study Start: January 1, 2018
• Primary Completion: April 30, 2022
• Study Completion: April 30, 2022
• Last Updated: August 15, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: CSR

Locations

CN (1)