Low-dose Whole Body Computed Tomography Scanning

NCT03425032 | Completed

• 1 other identifier: 16-5477
• Study Type: observational
• Target: 520
• Locations: 0 countries
• Sites: N/A

Brief Summary

Computed tomography represents the mainstay for diagnosing various diseases in the whole body. Over the past decade, enormous efforts were undertaken by both CT manufacturers and radiologist to reduce the radiation dose to patients. Today, the dose is significantly lower that it was before the era of multislice CT and iterative reconstruction methods. The X-ray beam originating from the tube in a CT system contains a spectrum of different energies, whereby the "harder" beams with higher energy penetrate the patient better, and the "softer" beams will be absorbed through the patient's tissues. Recent research has been shown that the radiation dose can be further reduced by improved primary beam filtering in CT. This study is intended to compare the radiation dose in clinically indicated, routine CT examination while maintaining a diagnostic image quality, on a new CT system with modified primary beam filtering.

Conditions

Computed Tomography; Image Quality

Outcome Measures

Primary Outcomes (1)

• Radiation dose

  Mean radiation dose (DLP), comparison to existing data (Radimetrics database)

  Through study completion, an average of 1 year

Interventions

CT scanner DEVICE

Regular CT imaging of the abdomen and pelvis

Also known as: Genesis TSX-350A CT scanner

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients will be routed to the new CT system in sequential order and as per clinical schedule. There will be no specific inclusion criteria for the study.

You may qualify if:

• Patients who are clinically scheduled for a CT of the body (any part, or a combination of different parts).

Sponsors & Collaborators

• University Health Network, Toronto: lead

Related Publications (3)

• Zhang G, Marshall N, Jacobs R, Liu Q, Bosmans H. Bowtie filtration for dedicated cone beam CT of the head and neck: a simulation study. Br J Radiol. 2013 Aug;86(1028):20130002. doi: 10.1259/bjr.20130002. Epub 2013 May 31.

  PMID: 23728948 RESULT

• Mail N, Moseley DJ, Siewerdsen JH, Jaffray DA. The influence of bowtie filtration on cone-beam CT image quality. Med Phys. 2009 Jan;36(1):22-32. doi: 10.1118/1.3017470.

  PMID: 19235370 RESULT

• Tkaczyk JE, Du Y, Walter D, Wu X, Li J, Toth T. Simulation of CT dose and contrast-to-noise as function of bowtie shape. Proc SPIE 2004;5368:403-410

  RESULT

MeSH Terms

Interventions

Tomography Scanners, X-Ray Computed

Intervention Hierarchy (Ancestors)

Equipment and Supplies

Study Officials

• Patrik Rogalla

  UHN

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 31, 2018
• First Posted: February 7, 2018
• Study Start: September 1, 2016
• Primary Completion: March 1, 2017
• Study Completion: January 1, 2018
• Last Updated: November 27, 2018

Record last verified: 2018-11

Data Sharing

• IPD Sharing: Will not share